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Slc26a6 Gene Detail
Summary
  • Symbol
    Slc26a6
  • Name
    solute carrier family 26, member 6
  • Synonyms
    B930010B04Rik, CFEX, Pat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159728
    NCBI Gene: 171429
  • Gene Overview
    MyGene.info: SLC26A6
Location & Maps
more
  • Sequence Map
    Chr9:108853283-108913049 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59767 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC26A6, solute carrier family 26 member 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC26A6, solute carrier family 26 member 6
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 65010
    neXtProt AC: NX_Q9BXS9

  • Chr Location
    3p21.3; chr3:48625723-48635493 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    3
  • Targeted
    3
  • Incidental Mutations
Homozygous null mice display abnormal proximal tubule and duodenal anion exchange, but are otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047370 VEGA Gene Model | MGI Sequence Detail 59767 C57BL/6J ±  kb
transcript OTTMUST00000129391 VEGA | MGI Sequence Detail 4362 Not Applicable  
polypeptide OTTMUSP00000069502 VEGA | MGI Sequence Detail 629 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015041 solute carrier family 26 member 6
  • InterPro Domains
    IPR001902 SLC26A/SulP transporter
    IPR011547 SLC26A/SulP transporter domain
    IPR030323 Solute carrier family 26 member 6
    IPR002645 STAS domain
    IPR018045 Sulphate anion transporter, conserved site
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
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MGI:2443071
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 18
    Phenotypes 22
  • Earliest
    J:75064 Knauf F, et al., Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30
  • Latest
    J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory