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Slc26a6 Gene Detail
Summary
  • Symbol
    Slc26a6
  • Name
    solute carrier family 26, member 6
  • Synonyms
    B930010B04Rik, CFEX, Pat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159728
    NCBI Gene: 171429
  • Gene Overview
    MyGene.info: SLC26A6
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108854043-108913049 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159728
protein coding gene Chr9:108853283-108913049 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035315
protein coding gene Chr9:110844257-110855748 (+)
A/J MGP_AJ_G0035294
protein coding gene Chr9:106779007-106790592 (+)
AKR/J MGP_AKRJ_G0035226
protein coding gene Chr9:109455624-109467151 (+)
BALB/cJ MGP_BALBcJ_G0035288
protein coding gene Chr9:106471282-106483232 (+)
C3H/HeJ MGP_C3HHeJ_G0034998
protein coding gene Chr9:109854682-109866006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035808
protein coding gene Chr9:113865506-113877086 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032706
protein coding gene Chr9:104188771-104199965 (+)
CAST/EiJ MGP_CASTEiJ_G0034309
protein coding gene Chr9:109821222-109835953 (+)
CBA/J MGP_CBAJ_G0034966
protein coding gene Chr9:117887946-117903264 (+)
DBA/2J MGP_DBA2J_G0035127
protein coding gene Chr9:106232007-106243386 (+)
FVB/NJ MGP_FVBNJ_G0035075
protein coding gene Chr9:104999978-105059989 (+)
LP/J MGP_LPJ_G0035203
protein coding gene Chr9:111032936-111045799 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035114
protein coding gene Chr9:119442350-119456617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035829
protein coding gene Chr9:109731209-109742793 (+)
PWK/PhJ MGP_PWKPhJ_G0034016
protein coding gene Chr9:106563663-106575412 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033851
protein coding gene Chr9:109798780-109810227 (+)
WSB/EiJ MGP_WSBEiJ_G0034430
protein coding gene Chr9:109623646-109635227 (+)



Homology
more
  • Human Ortholog
    SLC26A6, solute carrier family 26 member 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC26A6, solute carrier family 26 member 6
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 65010
    neXtProt AC: NX_Q9BXS9
    UniProt: Q9BXS9

  • Chr Location
    3p21.31; chr3:48625723-48635493 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal proximal tubule and duodenal anion exchange, but are otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171429 NCBI Gene Model | MGI Sequence Detail 59007 C57BL/6J ±  kb
    transcript NM_134420 RefSeq | MGI Sequence Detail 3329 C57BL/6  
    polypeptide Q8CIW6 UniProt | EBI | MGI Sequence Detail 758 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443071
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 19
      Phenotypes 23
    • Earliest
      J:75064 Knauf F, et al., Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30
    • Latest
      J:250103 Whittamore JM, et al., Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis. Am J Physiol Gastrointest Liver Physiol. 2017 Sep 1;313(3):G166-G179

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory