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Slc26a6 Gene Detail
Summary
  • Symbol
    Slc26a6
  • Name
    solute carrier family 26, member 6
  • Synonyms
    B930010B04Rik, CFEX, Pat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159728
    NCBI Gene: 171429
  • Gene Overview
    MyGene.info: SLC26A6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:108853283-108913049 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC26A6, solute carrier family 26 member 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC26A6, solute carrier family 26 member 6
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 65010
    neXtProt AC: NX_Q9BXS9
    UniProt: Q9BXS9

  • Chr Location
    3p21.31; chr3:48625723-48635493 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal proximal tubule and duodenal anion exchange, but are otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000047370 VEGA Gene Model | MGI Sequence Detail 59767 C57BL/6J ±  kb
    transcript OTTMUST00000129391 VEGA | MGI Sequence Detail 4362 Not Applicable  
    polypeptide OTTMUSP00000069502 VEGA | MGI Sequence Detail 628 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      19 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443071
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 18
      Phenotypes 23
    • Earliest
      J:75064 Knauf F, et al., Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30
    • Latest
      J:250103 Whittamore JM, et al., Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis. Am J Physiol Gastrointest Liver Physiol. 2017 Sep 1;313(3):G166-G179

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory