Slc26a6
Gene Detail

Symbol Name ID

Slc26a6 solute carrier family 26, member 6 MGI:2159728

Synonyms

B930010B04Rik, CFEX, Pat1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.63 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:108854037-108912558 bp, + strand From Ensembl annotation of GRCm38   58522 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99903  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: sulfate transport protein
Gene Tree: Slc26a6

Human homologs

Human Homolog		SLC26A6, solute carrier family 26, member 6
NCBI Gene ID		65010
neXtProt AC		NX_Q9BXS9
Human Chr (Location)		3p21.3; chr3:48663156-48672926 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)
 

Homozygous null mice display abnormal proximal tubule and duodenal anion exchange, but are otherwise normal.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	bicarbonate transport, chloride transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	anion:anion antiporter activity, chloride transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023259 (Evidence)
Entrez Gene	171429 (Evidence)
DFCI	TC1584490, TC1604076, TC1615082, TC1633732, TC1698437, TC1698996
DoTS	DT.101371240, DT.101371241, DT.101725964, DT.101725965, DT.101725966, DT.50314998, DT.91404229
NIA Mouse Gene Index	U011041
International Mouse Knockout Project Status	Slc26a6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023259	Ensembl Gene Model | MGI Sequence Detail	58522	C57BL/6J
transcript	ENSMUST00000098376	Ensembl | MGI Sequence Detail	2402	Not Applicable
polypeptide	ENSMUSP00000095979	Ensembl | MGI Sequence Detail	735	Not Applicable

All sequences(41) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002645	STAS domain
InterPro	IPR001902	Sulphate anion transporter
InterPro	IPR018045	Sulphate anion transporter, conserved site
InterPro	IPR011547	Sulphate transporter
Protein Ontology	PR:000015041	solute carrier family 26 member 6

References

(Earliest) J:75064 Knauf F, et al., Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30
(Latest) J:192779 Song Y, et al., Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct. Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C815-24
All references(48)

Other accession IDs

MGI:2443071