Sequence Detail

ID/Version

Q8CIW6 Q8CJD0 E9Q4D3 Q8K142 Q3TQD3 Q812E2 Q923J3 (UniProt | EBI)

Last sequence update: 2013-09-18
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Solute carrier family 26 member 6;AltName: Full=Anion exchange transporter;AltName: Full=Chloride-formate exchanger;AltName: Full=Pendrin-L1;AltName: Full=Pendrin-like protein 1;AltName: Full=Putative anion transporter-1; Short=Pat-1

Provider

SWISS-PROT

Sequence

Polypeptide 758 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc26a6	solute carrier family 26, member 6	98	97	5	5

Sequence references in MGI

J:75064 Knauf F, et al., Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30
J:75548 Wang Z, et al., Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G573-9
J:79463 Xie Q, et al., Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol. 2002 Oct;283(4):F826-38
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101422 Thomson RB, et al., Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13331-6
J:107558 Jiang Z, et al., Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet. 2006 Apr;38(4):474-8
J:121543 Simpson JE, et al., PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1079-88
J:144457 Wang Y, et al., Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J. 2006 Nov 1;25(21):5049-57
J:152870 Singh AK, et al., Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008 Aug;74(4):438-47
J:159253 Simpson JE, et al., Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G683-91
J:185780 Chavez JC, et al., Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan;86(1):1-14
J:192779 Song Y, et al., Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct. Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C815-24
J:201564 Hassan HA, et al., Regulation of anion exchanger Slc26a6 by protein kinase C. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1485-92
J:201569 Jiang Z, et al., Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem. 2002 Sep 13;277(37):33963-7
J:201940 Knauf F, et al., Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol. 2011 Dec;22(12):2247-55
J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41
J:263699 Mukaibo T, et al., The apical anion exchanger Slc26a6 promotes oxalate secretion by murine submandibular gland acinar cells. J Biol Chem. 2018 Apr 27;293(17):6259-6268
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333127 Shcheynikov N, et al., Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol. 2006 May;127(5):511-24
J:333128 Walker NM, et al., Functional activity of Pat-1 (Slc26a6) Cl(-)/HCO(3)(-) exchange in the lower villus epithelium of murine duodenum. Acta Physiol (Oxf). 2011 Jan;201(1):21-31
J:333163 Kim HJ, et al., Slc26a6 functions as an electrogenic Cl-/HCO3- exchanger in cardiac myocytes. Cardiovasc Res. 2013 Dec 1;100(3):383-91
J:333178 Nozawa T, et al., Role of anion exchange transporter PAT1 (SLC26A6) in intestinal absorption of organic anions. J Drug Target. 2004 Feb;12(2):97-104