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Kcnh7 Gene Detail
Summary
  • Symbol
    Kcnh7
  • Name
    potassium voltage-gated channel, subfamily H (eag-related), member 7
  • Synonyms
    9330137I11Rik, erg3, Kv11.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159566
    NCBI Gene: 170738
  • Gene Overview
    MyGene.info: KCNH7
Location & Maps
more
  • Sequence Map
    Chr2:62693414-63184287 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      490874 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 36.50 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KCNH7, potassium voltage-gated channel subfamily H member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNH7, potassium voltage-gated channel subfamily H member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERG3, HERG3, Kv11.3
  • Links
    NCBI Gene ID: 90134
    neXtProt AC: NX_Q9NS40

  • Chr Location
    2q24.2; chr2:162371407-162838747 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Kcnh7
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012800 VEGA Gene Model | MGI Sequence Detail 490874 C57BL/6J ±  kb
transcript OTTMUST00000030676 VEGA | MGI Sequence Detail 13321 Not Applicable  
polypeptide OTTMUSP00000013759 VEGA | MGI Sequence Detail 1195 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2955 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000796 voltage-gated potassium channel KCNH7
  • InterPro Domains
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR005821 Ion transport domain
    IPR000014 PAS domain
    IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
    IPR003967 Potassium channel, voltage-dependent, ERG
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 8
    cDNA 6
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2444334
References
more
  • Summaries
    All 24
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory