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Slc34a3 Gene Detail
Summary
  • Symbol
    Slc34a3
  • Name
    solute carrier family 34 (sodium phosphate), member 3
  • Synonyms
    Npt2c, NPTIIc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159410
    NCBI Gene: 142681
  • Gene Overview
    MyGene.info: SLC34A3
Location & Maps
more
  • Sequence Map
    Chr2:25228898-25234364 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5467 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC34A3, solute carrier family 34 member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC34A3, solute carrier family 34 member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HHRH, NPTIIc
  • Links
    NCBI Gene ID: 142680
    neXtProt AC: NX_Q8N130

  • Chr Location
    9q34; chr9:137230116-137236554 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC34A3 associations

Human Disease Mouse Models
       Hypophosphatemic Rickets with Hypercalciuria, Hereditary; HHRH   OMIM: 241530 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit hypercalciuria, hypercalcemia and increased plasma 1,25(OH)2D3 levels but do not develop hypophosphatemia, renal calcification, rickets, or osteomalacia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011890 VEGA Gene Model | MGI Sequence Detail 5467 C57BL/6J ±  kb
transcript OTTMUST00000028045 VEGA | MGI Sequence Detail 2183 Not Applicable  
polypeptide OTTMUSP00000012713 VEGA | MGI Sequence Detail 601 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015088 sodium-dependent phosphate transport protein 2C
  • InterPro Domains
    IPR003841 Sodium-dependent phosphate transport protein
    IPR029850 Sodium-dependent phosphate transport protein 2C
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139031
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:73893 Ohkido I, et al., Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney. Pflugers Arch. 2003 Apr;446(1):106-15
  • Latest
    J:211926 Ohata Y, et al., Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014 Jul;29(7):1627-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory