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Slc34a3
Gene Detail
Symbol

Name
ID
Slc34a3
solute carrier family 34 (sodium phosphate), member 3
MGI:2159410
Synonyms
Npt2c, NPTIIc
Feature Type
protein coding gene
Genetic Map
Chromosome 2
17.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:25228898-25234364 bp, - strand
From VEGA annotation of GRCm38

  5467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SLC34A3
Gene Tree: Slc34a3

Human
homologs
SLC34A3, solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 142680
neXtProt AC: NX_Q8N130

Human Synonyms: HHRH, NPTIIc

Human Chr (Location): 9q34; chr9:137230116-137236554 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC34A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit hypercalciuria, hypercalcemia and increased plasma 1,25(OH)2D3 levels but do not develop hypophosphatemia, renal calcification, rickets, or osteomalacia.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Slc34a3 interacts with 23 markers (Mir20a, Mir34a, Mir93, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc34a3    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011890 (Evidence)
Ensembl Gene Model ENSMUSG00000006469 (Evidence)
Entrez Gene 142681 (Evidence)
DFCI TC1587588, TC1672821, TC1717972
DoTS DT.485843, DT.60103403, DT.87059391
NIA Mouse Gene Index U022379
Consensus CDS Project CCDS15754.1
International Mouse Phenotyping Consortium Status Slc34a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011890 VEGA Gene Model | MGI Sequence Detail 5467 C57BL/6J ±  kb
transcript OTTMUST00000028045 VEGA | MGI Sequence Detail 2183 Not Applicable 
polypeptide OTTMUSP00000012713 VEGA | MGI Sequence Detail 601 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(18) UniProt(2)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003841 Sodium-dependent phosphate transport protein
InterPro IPR029850 Sodium-dependent phosphate transport protein 2C
Protein Ontology PR:000015088 sodium-dependent phosphate transport protein 2C
References
(Earliest) J:73893 Ohkido I, et al., Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney. Pflugers Arch. 2003 Apr;446(1):106-15
(Latest) J:211926 Ohata Y, et al., Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014 Jul;29(7):1627-38
All references(37)
Other
accession IDs
MGI:2139031

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory