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Slc34a3 Gene Detail
Summary
  • Symbol
    Slc34a3
  • Name
    solute carrier family 34 (sodium phosphate), member 3
  • Synonyms
    Npt2c, NPTIIc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159410
    NCBI Gene: 142681
  • Gene Overview
    MyGene.info: SLC34A3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25228897-25234271 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159410
protein coding gene Chr2:25228897-25234364 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025427
protein coding gene Chr2:23095265-23100729 (-)
A/J MGP_AJ_G0025404
protein coding gene Chr2:22207185-22212698 (-)
AKR/J MGP_AKRJ_G0025374
protein coding gene Chr2:22950171-22955648 (-)
BALB/cJ MGP_BALBcJ_G0025400
protein coding gene Chr2:22317937-22323462 (-)
C3H/HeJ MGP_C3HHeJ_G0025161
protein coding gene Chr2:22877439-22882907 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025844
protein coding gene Chr2:23828522-23833788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023255
protein coding gene Chr2:21126082-21131474 (-)
CAST/EiJ MGP_CASTEiJ_G0024624
protein coding gene Chr2:22760897-22766369 (-)
CBA/J MGP_CBAJ_G0025139
protein coding gene Chr2:24668372-24673626 (-)
DBA/2J MGP_DBA2J_G0025272
protein coding gene Chr2:22050526-22056385 (-)
FVB/NJ MGP_FVBNJ_G0025234
protein coding gene Chr2:21789662-21795143 (-)
LP/J MGP_LPJ_G0025358
protein coding gene Chr2:23039437-23045215 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025265
protein coding gene Chr2:24869445-24875728 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025903
protein coding gene Chr2:22894926-22903772 (-)
PWK/PhJ MGP_PWKPhJ_G0024372
protein coding gene Chr2:21862189-21867662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024172
protein coding gene Chr2:23052389-23057846 (-)
WSB/EiJ MGP_WSBEiJ_G0024693
protein coding gene Chr2:22967957-22973483 (-)



Homology
more
  • Human Ortholog
    SLC34A3, solute carrier family 34 member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC34A3, solute carrier family 34 member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HHRH, NPTIIc
  • Links
    NCBI Gene ID: 142680
    neXtProt AC: NX_Q8N130
    UniProt: Q8N130

  • Chr Location
    9q34.3; chr9:137230757-137236554 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SLC34A3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypercalciuria, hypercalcemia and increased plasma 1,25(OH)2D3 levels but do not develop hypophosphatemia, renal calcification, rickets, or osteomalacia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 142681 NCBI Gene Model | MGI Sequence Detail 5375 C57BL/6J ±  kb
    transcript NM_001362748 RefSeq | MGI Sequence Detail 2133 C57BL/6  
    polypeptide Q80SU6 UniProt | EBI | MGI Sequence Detail 601 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015088 sodium-dependent phosphate transport protein 2C
    • InterPro Domains
      IPR003841 Sodium-dependent phosphate transport protein
      IPR029850 Sodium-dependent phosphate transport protein 2C
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 6
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139031
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:73893 Ohkido I, et al., Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney. Pflugers Arch. 2003 Apr;446(1):106-15
    • Latest
      J:257428 Merametdjian L, et al., Expression of Phosphate Transporters during Dental Mineralization. J Dent Res. 2018 Feb;97(2):209-217

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory