About   Help   FAQ
Slc34a3
Gene Detail
 Symbol
Name
ID
Slc34a3
solute carrier family 34 (sodium phosphate), member 3
MGI:2159410
Synonyms Npt2c, NPTIIc
Feature Type protein coding gene
Genetic Map
Chromosome 2
17.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:25228898-25234364 bp, - strand
From VEGA annotation of GRCm38

  5467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Slc34a3

Human
homologs
Human Homolog SLC34A3, solute carrier family 34 (type II sodium/phosphate contransporter), member 3
NCBI Gene ID 142680
neXtProt AC  NX_Q8N130
Human Synonyms  HHRH, NPTIIc
Human Chr (Location)  9q34; chr9:137230757-137236554 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC34A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit hypercalciuria, hypercalcemia and increased plasma 1,25(OH)2D3 levels but do not develop hypophosphatemia, renal calcification, rickets, or osteomalacia.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Slc34a3 interacts with 23 markers (Mir20a, Mir34a, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular phosphate ion homeostasis, ion transport, ...
Component apical plasma membrane, brush border, ...
Function sodium-dependent phosphate transmembrane transporter activity, sodium:phosphate symporter activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011890 (Evidence)
Ensembl Gene ModelENSMUSG00000006469 (Evidence)
Entrez Gene142681 (Evidence)
DFCITC1587588, TC1672821, TC1717972
DoTSDT.485843, DT.60103403, DT.87059391
NIA Mouse Gene IndexU022379
Consensus CDS ProjectCCDS15754.1
International Mouse Knockout Project StatusSlc34a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011890 VEGA Gene Model | MGI Sequence Detail 5467 C57BL/6J ±  kb
transcript OTTMUST00000028045 VEGA | MGI Sequence Detail 2183 Not Applicable 
polypeptide OTTMUSP00000012713 VEGA | MGI Sequence Detail 601 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(16) UniProt(1)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003841 Sodium-dependent phosphate transport protein
Protein Ontology PR:000015088 sodium-dependent phosphate transport protein 2C
References (Earliest) J:73893 Ohkido I, et al., Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney. Pflugers Arch. 2003 Apr;446(1):106-15
(Latest) J:197919 Guo J, et al., Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice. Endocrinology. 2013 May;154(5):1680-9
All references(36)
Other
accession IDs
MGI:2139031

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory