Slc34a3
Gene Detail

Symbol Name ID

Slc34a3 solute carrier family 34 (sodium phosphate), member 3 MGI:2159410

Synonyms

Npt2c, NPTIIc

Feature Type

protein coding gene

Genetic Map

Chromosome 2

17.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:25228898-25234364 bp, - strand From VEGA annotation of GRCm38   5467 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc34a3

Human homologs

Human Homolog		SLC34A3, solute carrier family 34 (sodium phosphate), member 3
NCBI Gene ID		142680
neXtProt AC		NX_Q8N130
Human Synonyms		HHRH, NPTIIc
Human Chr (Location)		9q34; chr9:140125209-140131006 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC34A3

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit hypercalciuria, hypercalcemia and increased plasma 1,25(OH)2D3 levels but do not develop hypophosphatemia, renal calcification, rickets, or osteomalacia.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular phosphate ion homeostasis, ion transport, ...
Component	apical plasma membrane, brush border, ...
Function	sodium-dependent phosphate transmembrane transporter activity, sodium:phosphate symporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011890 (Evidence)
Ensembl Gene Model	ENSMUSG00000006469 (Evidence)
Entrez Gene	142681 (Evidence)
UniGene	346652
DFCI	TC1587588, TC1672821, TC1717972
DoTS	DT.485843, DT.60103403, DT.87059391
NIA Mouse Gene Index	U022379
Consensus CDS Project	CCDS15754.1
International Mouse Knockout Project Status	Slc34a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011890	VEGA Gene Model | MGI Sequence Detail	5467	C57BL/6J
transcript	OTTMUST00000028045	VEGA | MGI Sequence Detail	2183	Not Applicable
polypeptide	OTTMUSP00000012713	VEGA | MGI Sequence Detail	601	Not Applicable

All sequences(38) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003841	Sodium-dependent phosphate transport protein
Protein Ontology	PR:000015088	sodium-dependent phosphate transport protein 2C

References

(Earliest) J:73893 Ohkido I, et al., Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney. Pflugers Arch. 2003 Apr;446(1):106-15
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Other accession IDs

MGI:2139031