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Targeted Allele Detail
Symbol: Slc34a1tm1Hten
Name: solute carrier family 34 (sodium phosphate), member 1; targeted mutation 1, Harriet S Tenenhouse
MGI ID: MGI:2386786
Synonyms: NaPi2a-, Npt2-, Npt2a KO
Gene: Slc34a1  Location: Chr13:55547435-55562508 bp, + strand  Genetic Position: Chr13, 29.81 cM, cytoband B
Alliance: Slc34a1tm1Hten page
Histological appearance of bone from wild-type, Slc34a1tm1Hten/Slc34a1+ and Slc34a1tm1Hten/Slc34a1tm1Hten mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:47637
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 6 through 10 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded amino acids 178 through 389. Northern blot and RT-PCR analyses showed reduced levels of transcript in heterozygous mice and and an absence of transcript in homozygous mutant mice. While protein was undetected in homozygous mutant mice by Western blot analysis of renal tissue, normal levels of protein were detected in heterozygotes. (J:47637)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc34a1 Mutation:  32 strains or lines available
Original:  J:47637 Beck L, et al., Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5372-7
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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