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Cln6
Gene Detail
Symbol

Name
ID
Cln6
ceroid-lipofuscinosis, neuronal 6
MGI:2159324
Synonyms
1810065L06Rik, D9Bwg1455e
Feature Type
protein coding gene
Genetic Map
Chromosome 9
33.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:62838785-62852006 bp, + strand
From VEGA annotation of GRCm38

  13222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLN6
Gene Tree: Cln6

Human
homologs
CLN6, ceroid-lipofuscinosis, neuronal 6, late infantile, variant
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54982
neXtProt AC: NX_Q9NWW5

Human Synonyms: CLN4A, HsT18960, nclf

Human Chr (Location): 15q23; chr15:68206992-68229742 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CLN6

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have progressive retinal atrophy, limb paralysis, and seizures that lead to early death.
 
Human Diseases Modeled in Mice Using Cln6 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Cln6 interacts with 117 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (38)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
cDNA source data(54)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cln6 ; ZFIN cln6a    NEW 
Molecular
reagents
All nucleic(58) cDNA(55) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033326 (Evidence)
Ensembl Gene Model ENSMUSG00000032245 (Evidence)
Entrez Gene 76524 (Evidence)
UniGene 283636
DFCI TC1577242
DoTS DT.110644527, DT.531732, DT.94375608
NIA Mouse Gene Index U010600
Consensus CDS Project CCDS23267.1
International Mouse Phenotyping Consortium Status Cln6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033326 VEGA Gene Model | MGI Sequence Detail 13222 C57BL/6J ±  kb
transcript OTTMUST00000083630 VEGA | MGI Sequence Detail 2142 Not Applicable 
polypeptide OTTMUSP00000044963 VEGA | MGI Sequence Detail 308 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005593 ceroid-lipofuscinosis neuronal protein 6
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:211608 Damme M, et al., Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease. Neurobiol Dis. 2014 May;65:12-24
All references(55)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-34102, MGI:106408, MGI:1202067, MGI:1923774, MGI:2143349

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory