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Cln6
Gene Detail
 Symbol
Name
ID
Cln6
ceroid-lipofuscinosis, neuronal 6
MGI:2159324
Synonyms 1810065L06Rik, D9Bwg1455e
Feature Type protein coding gene
Genetic Map
Chromosome 9
33.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:62838785-62852006 bp, + strand
From VEGA annotation of GRCm38

  13222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cln6

Human
homologs
Human Homolog CLN6, ceroid-lipofuscinosis, neuronal 6, late infantile, variant
NCBI Gene ID 54982
neXtProt AC  NX_Q9NWW5
Human Synonyms  CLN4A, HsT18960, nclf
Human Chr (Location)  15q23; chr15:68206992-68229742 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CLN6
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have progressive retinal atrophy, limb paralysis, and seizures that lead to early death.
 
Human Diseases Modeled Using Mouse Cln6 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cln6 interacts with 117 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular macromolecule catabolic process, cholesterol metabolic process, ...
Component endoplasmic reticulum, endoplasmic reticulum lumen, ...
Function protein homodimerization activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (38)    Images (20)
Theiler Stages: 19, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 55
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(55) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033326 (Evidence)
Ensembl Gene ModelENSMUSG00000032245 (Evidence)
Entrez Gene76524 (Evidence)
UniGene283636
DFCITC1577242
DoTSDT.110644527, DT.531732, DT.94375608
NIA Mouse Gene IndexU010600
Consensus CDS ProjectCCDS23267.1
International Mouse Knockout Project StatusCln6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033326 VEGA Gene Model | MGI Sequence Detail 13222 C57BL/6J ±  kb
transcript OTTMUST00000083630 VEGA | MGI Sequence Detail 2142 Not Applicable 
polypeptide OTTMUSP00000044963 VEGA | MGI Sequence Detail 308 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005593 ceroid-lipofuscinosis neuronal protein 6
References (Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:209216 Morgan JP, et al., A murine model of variant late infantile ceroid lipofuscinosis recapitulates behavioral and pathological phenotypes of human disease. PLoS One. 2013;8(11):e78694
All references(53)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-34102, MGI:106408, MGI:1202067, MGI:1923774, MGI:2143349

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory