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Otud7a Gene Detail
Summary
  • Symbol
    Otud7a
  • Name
    OTU domain containing 7A
  • Synonyms
    Cezanne 2 protein, Otud7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158505
    NCBI Gene: 170711
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:63444751-63759028 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158505
protein coding gene Chr7:63444745-63766232 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032331
protein coding gene Chr7:64504677-64860222 (+)
A/J MGP_AJ_G0032310
protein coding gene Chr7:63304170-63635288 (+)
AKR/J MGP_AKRJ_G0032246
protein coding gene Chr7:64648631-64974417 (+)
BALB/cJ MGP_BALBcJ_G0032322
protein coding gene Chr7:62998394-63371804 (+)
C3H/HeJ MGP_C3HHeJ_G0032035
protein coding gene Chr7:65302004-65616455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032815
protein coding gene Chr7:67308468-67652271 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029822
protein coding gene Chr7:66294603-66596377 (+)
CAST/EiJ MGP_CASTEiJ_G0031364
protein coding gene Chr7:55947784-56277794 (+)
CBA/J MGP_CBAJ_G0032001
protein coding gene Chr7:69472161-69834201 (+)
DBA/2J MGP_DBA2J_G0032157
protein coding gene Chr7:62065827-62372543 (+)
FVB/NJ MGP_FVBNJ_G0032111
protein coding gene Chr7:62160126-62463391 (+)
LP/J MGP_LPJ_G0032237
protein coding gene Chr7:65770602-66098083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032148
protein coding gene Chr7:69797062-70150372 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032832
protein coding gene Chr7:63900965-64228846 (+)
PWK/PhJ MGP_PWKPhJ_G0031084
protein coding gene Chr7:55067152-55383162 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030925
protein coding gene Chr7:51037652-51379098 (+)
WSB/EiJ MGP_WSBEiJ_G0031482
protein coding gene Chr7:64289423-64623812 (+)



Homology
more
  • Human Ortholog
    OTUD7A, OTU deubiquitinase 7A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OTUD7A, OTU deubiquitinase 7A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C15orf16, C16ORF15, CEZANNE2, OTUD7
  • Links
    NCBI Gene ID: 161725
    neXtProt AC: NX_Q8TE49
    UniProt: Q8TE49

  • Chr Location
    15q13.3; chr15:31483126-31655339 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Otud7a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, abnormal spike wave discharge, decreased dendritic spine density, decreased prepulse inhibition, impaired coordination, decreased grip strength, decreased startle reflex, impaired ultrasonic vocalization and delayed tooth eruption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033510 Ensembl Gene Model | MGI Sequence Detail 314278 C57BL/6J ±  kb
transcript ENSMUST00000058476 Ensembl | MGI Sequence Detail 3483 Not Applicable  
polypeptide ENSMUSP00000057282 Ensembl | MGI Sequence Detail 926 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Diseases 3
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:259730 Yin J, et al., Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome. Am J Hum Genet. 2018 Feb 1;102(2):296-308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory