Phenotypes Associated with This Genotype

Genotype
MGI:6150674

• Allelic Composition: Del(7Chrna7-Fan1)3Arte/+
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:260165 )

• slightly fewer than expected mice survive to weaning

behavior/neurological

behavior/neurological phenotype ( J:260165 )

♂N • mice exhibit normal behavior including pain sensitivity, motor function, anxiety response, behaviors in the y-maze, alternation task and in cued and contextual fear conditioning

abnormal seizure response to pharmacological agent ( J:260165 )

♂ • PTZ-treated mice exhibit delayed onset and lower frequency of clonic and tonic seizures, but an increase in propensity for myoclonic jerks, compared with wild-type mice

♂ • PTZ-treated mice exhibit more single spikes than wild-type mice and increased frequency and total duration of absence-like seizures in the frontal cortex

decreased susceptibility to pharmacologically induced seizures ( J:260165 )

♂ • mice exhibit protection from nicotine-clonic seizures compared with wild-type mice

impaired spatial learning ( J:260165 )

♂ • decreased distance spent in target quadrant of a Morris water maze

increased aggression towards mice ( J:260165 )

♂ • when reintroduced into home cages

♂ • however, mice do not exhibit an increase in restrain-induced corticosterone levels

decreased startle reflex ( J:260165 )

♂ • baseline

decreased locomotor activity ( J:260165 )

♂ • slightly during habituation

♂ • however, activity following challenge with amphetamine or PCP is normal

abnormal seizure response to electrical stimulation ( J:260165 )

♂ • in the maximal electroshock seizure threshold assay, mice exhibit strong protection from electrically-induced tonic seizures compared with wild-type mice

nervous system

nervous system phenotype ( J:260165 )

♂N • mice exhibit normal brain weight and morphology with normal amphetamine- or PCP-disrupted prepulse inhibition

abnormal seizure response to pharmacological agent ( J:260165 )

♂ • PTZ-treated mice exhibit delayed onset and lower frequency of clonic and tonic seizures, but an increase in propensity for myoclonic jerks, compared with wild-type mice

♂ • PTZ-treated mice exhibit more single spikes than wild-type mice and increased frequency and total duration of absence-like seizures in the frontal cortex

decreased susceptibility to pharmacologically induced seizures ( J:260165 )

♂ • mice exhibit protection from nicotine-clonic seizures compared with wild-type mice

abnormal seizure response to electrical stimulation ( J:260165 )

♂ • in the maximal electroshock seizure threshold assay, mice exhibit strong protection from electrically-induced tonic seizures compared with wild-type mice

growth/size/body

increased body weight ( J:260165 )

♂ • beginning at 6 to 7 weeks of age as mice move into puberty

hearing/vestibular/ear

abnormal auditory brainstem response ( J:260165 )

♂ • reduced loudness dependence auditory evoked potential (LDAEP) in parietal and frontal cortex, but not the hippocampus

♂ • reduced N1 and P2 AEP amplitudes in response to the first and second stimuli in the parietal cortex using the auditory double-click paradigm

♂ • auditory stimulation (40 Hz) failed to induce an increase in gamma power in the parietal cortex, frontal cortex and hippocampus unlike in wild-type mice with a reduction in peak theta frequency in the hippocampus and prelimbic cortex

♂ • however, mice exhibit normal AEP gating ratios and increase in gamma power in the prelimbic cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 15q13.3 microdeletion syndrome		DOID:0060394	OMIM:612001	J:260165