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Tlr3
Gene Detail
 Symbol
Name
ID
Tlr3
toll-like receptor 3
MGI:2156367
Feature Type protein coding gene
Genetic Map
Chromosome 8
25.31 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:45395665-45410539 bp, - strand
From NCBI annotation of GRCm38

  14875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: toll-like receptor 3
Gene Tree: Tlr3

Human
homologs
Human Homolog TLR3, toll-like receptor 3
NCBI Gene ID 7098
neXtProt AC  NX_O15455
Human Synonyms  CD283, IIAE2
Human Chr (Location)  4q35; chr4:186059050-186085098 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TLR3
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells.
 
Interactions
Tlr3 interacts with 204 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process cellular response to exogenous dsRNA, defense response, ...
Component cell surface, cytoplasm, ...
Function double-stranded RNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (31)    Tissues (16)    Images (9)
Theiler Stages: 23
Assay TypeResults
RNA in situ 31
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031639 (Evidence)
Entrez Gene142980 (Evidence)
UniGene33874
DFCITC1580399
DoTSDT.101219717, DT.101370883, DT.40184438, DT.94386761
NIA Mouse Gene IndexU029778
PDB3CIG, 3CIY
Consensus CDS ProjectCCDS22278.1
International Mouse Knockout Project StatusTlr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 142980 NCBI Gene Model | MGI Sequence Detail 14875 C57BL/6J ±  kb
transcript NM_126166 RefSeq | MGI Sequence Detail 4327 C57BL/6 
polypeptide Q99MB1 UniProt | EBI | MGI Sequence Detail 905 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(4)
Polymorphisms SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027173 Toll-like receptor 3
Protein Ontology PR:000001154 Toll-like receptor 3
Graphical View of Protein Domain Structure
References (Earliest) J:43870 Steroid Nomenclature, Steroid Nomenclature. J Steroid Biochem Mol Biol. 1997;62(1):ix-xi
(Latest) J:212209 Wilson CL, et al., Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. PLoS One. 2014;9(1):e83391
All references(247)
Other
accession IDs
MGI:2142652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory