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Tlr3 Gene Detail
Summary
  • Symbol
    Tlr3
  • Name
    toll-like receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156367
    NCBI Gene: 142980
  • Gene Overview
    MyGene.info: TLR3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:45395665-45411080 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15416 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 25.31 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TLR3, toll like receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLR3, toll like receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD283, IIAE2
  • Links
    NCBI Gene ID: 7098
    neXtProt AC: NX_O15455
    UniProt: O15455

  • Chr Location
    4q35.1; chr4:186069155-186086724 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TLR3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 4 alleles in 8 genetic backgrounds
    219 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061136 VEGA Gene Model | MGI Sequence Detail 15416 C57BL/6J ±  kb
    transcript OTTMUST00000149295 VEGA | MGI Sequence Detail 4407 Not Applicable  
    polypeptide OTTMUSP00000077473 VEGA | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      48 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 24

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142652
    References
    more
    • Summaries
      All 356
      Developmental Gene Expression 6
      Gene Ontology 21
      Phenotypes 219
    • Earliest
      J:43870 Steroid Nomenclature, Steroid Nomenclature. J Steroid Biochem Mol Biol. 1997;62(1):ix-xi
    • Latest
      J:263189 Simons KH, et al., The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease. J Mol Cell Cardiol. 2018 Jun 4;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory