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Tlr3
Gene Detail
Symbol

Name
ID
Tlr3
toll-like receptor 3
MGI:2156367
Feature Type
protein coding gene
Genetic Map
Chromosome 8
25.31 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:45395665-45410608 bp, - strand
From Ensembl annotation of GRCm38

  14944 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLR3
Protein SuperFamily: toll-like receptor 3
Gene Tree: Tlr3

Human
homologs
TLR3, toll-like receptor 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7098
neXtProt AC: NX_O15455

Human Synonyms: CD283, IIAE2

Human Chr (Location): 4q35; chr4:186069155-186085098 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TLR3

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells.
 
Interactions
Tlr3 interacts with 204 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process cellular response to exogenous dsRNA, defense response, ...
Component cell surface, cytoplasm, ...
Function double-stranded RNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (31)    Tissues (16)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tlr3    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031639 (Evidence)
Entrez Gene 142980 (Evidence)
UniGene 33874
DFCI TC1580399
DoTS DT.40184438, DT.101370883, DT.101219717, DT.94386761
NIA Mouse Gene Index U029778
PDB 3CIG, 3CIY
Consensus CDS Project CCDS22278.1
International Mouse Phenotyping Consortium Status Tlr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031639 Ensembl Gene Model | MGI Sequence Detail 14944 C57BL/6J ±  kb
transcript ENSMUST00000034056 Ensembl | MGI Sequence Detail 4327 Not Applicable 
polypeptide ENSMUSP00000034056 Ensembl | MGI Sequence Detail 905 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(16) UniProt(4)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027173 Toll-like receptor 3
Protein Ontology PR:000001154 Toll-like receptor 3
References
(Earliest) J:43870 Steroid Nomenclature, Steroid Nomenclature. J Steroid Biochem Mol Biol. 1997;62(1):ix-xi
(Latest) J:220770 McCall KD, et al., Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice. Endocrinology. 2015 Feb;156(2):453-61
All references(261)
Other
accession IDs
MGI:2142652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory