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Tlr3 Gene Detail
Summary
  • Symbol
    Tlr3
  • Name
    toll-like receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156367
    NCBI Gene: 142980
Location & Maps
more
  • Sequence Map
    Chr8:45395665-45410608 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14944 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TLR3, toll like receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLR3, toll like receptor 3
    Orthology source: HomoloGene
  • Synonyms
    CD283, IIAE2
  • Links
    NCBI Gene ID: 7098
    neXtProt AC: NX_O15455

  • Chr Location
    4q35; chr4:186069155-186085098 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TLR3 associations

Human Disease Mouse Models
       Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 7 genetic backgrounds
    186 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Tlr3
  • Incidental Mutations
Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031639 Ensembl Gene Model | MGI Sequence Detail 14944 C57BL/6J ±  kb
transcript ENSMUST00000034056 Ensembl | MGI Sequence Detail 4327 Not Applicable  
polypeptide ENSMUSP00000034056 Ensembl | MGI Sequence Detail 905 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001154 Toll-like receptor 3
  • PDB
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
    IPR027173 Toll-like receptor 3
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 4
Other
Accession IDs
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MGI:2142652
References
more
  • Summaries
    All 272
    Developmental Gene Expression 4
    Gene Ontology 19
    Phenotypes 186
  • Earliest
    J:43870 Steroid Nomenclature, Steroid Nomenclature. J Steroid Biochem Mol Biol. 1997;62(1):ix-xi
  • Latest
    J:227257 Hu W, et al., Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13994-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory