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Tlr3 Gene Detail
Summary
  • Symbol
    Tlr3
  • Name
    toll-like receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156367
    NCBI Gene: 142980
  • Gene Overview
    MyGene.info: TLR3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45395665-45411080 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 25.31 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156367
protein coding gene Chr8:45395665-45411949 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033576
protein coding gene Chr8:44444713-44459534 (-)
A/J MGP_AJ_G0033558
protein coding gene Chr8:42740636-42756188 (-)
AKR/J MGP_AKRJ_G0033483
protein coding gene Chr8:43990329-44005906 (-)
BALB/cJ MGP_BALBcJ_G0033555
protein coding gene Chr8:42904670-42919778 (-)
C3H/HeJ MGP_C3HHeJ_G0033264
protein coding gene Chr8:44517865-44533928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034071
protein coding gene Chr8:46134001-46153968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031020
protein coding gene Chr8:39038725-39052915 (-)
CAST/EiJ MGP_CASTEiJ_G0032590
protein coding gene Chr8:43936322-43953453 (-)
CBA/J MGP_CBAJ_G0033243
protein coding gene Chr8:47991068-48007909 (-)
DBA/2J MGP_DBA2J_G0033396
protein coding gene Chr8:42546648-42561571 (-)
FVB/NJ MGP_FVBNJ_G0033337
protein coding gene Chr8:42039708-42054173 (-)
LP/J MGP_LPJ_G0033484
protein coding gene Chr8:44457205-44473683 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033382
protein coding gene Chr8:48063040-48079217 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034089
protein coding gene Chr8:44153138-44168839 (-)
PWK/PhJ MGP_PWKPhJ_G0032298
protein coding gene Chr8:42075953-42091373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032134
protein coding gene Chr8:43313369-43328076 (-)
WSB/EiJ MGP_WSBEiJ_G0032706
protein coding gene Chr8:44403774-44419361 (-)



Homology
more
  • Human Ortholog
    TLR3, toll like receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLR3, toll like receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD283, IIAE2
  • Links
    NCBI Gene ID: 7098
    neXtProt AC: NX_O15455
    UniProt: O15455

  • Chr Location
    4q35.1; chr4:186069155-186086724 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TLR3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 4 alleles in 8 genetic backgrounds
    220 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031639 Ensembl Gene Model | MGI Sequence Detail 15416 C57BL/6J ±  kb
    transcript ENSMUST00000034056 Ensembl | MGI Sequence Detail 4407 Not Applicable  
    polypeptide ENSMUSP00000034056 Ensembl | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 24

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142652
    References
    more
    • Summaries
      All 357
      Developmental Gene Expression 6
      Gene Ontology 22
      Phenotypes 220
    • Earliest
      J:43870 Steroid Nomenclature, Steroid Nomenclature. J Steroid Biochem Mol Biol. 1997;62(1):ix-xi
    • Latest
      J:263189 Simons KH, et al., The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease. J Mol Cell Cardiol. 2018 Jun 4;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory