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Slc17a6
Gene Detail
Symbol

Name
ID
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
MGI:2156052
Synonyms
2900073D12Rik, VGLUT2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
32.78 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:51621830-51671125 bp, + strand
From Ensembl annotation of GRCm38

  49296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc17a6

Human
homologs
Human Homolog SLC17A6, solute carrier family 17 (vesicular glutamate transporter), member 6
NCBI Gene ID 57084
neXtProt AC  NX_Q9P2U8
Human Synonyms  DNPI, VGLUT2
Human Chr (Location)  11p14.3; chr11:22338121-22379503 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations display neonatal lethality, respiratory failure, and abnormal nervous system physiology. Heterozygous mice for one allele display abnormal miniature EPSC and reduced responses to neuropathic pain.
 
Interactions
Slc17a6 interacts with 325 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process ion transport, L-glutamate transmembrane transport, ...
Component cell junction, cytoplasmic vesicle, ...
Function L-glutamate transmembrane transporter activity, symporter activity
External Resources: FuncBase
Expression
Literature Summary: (95 records)
Data Summary: Results (278)    Tissues (68)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 267
Western blot 3
RT-PCR 3
cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(34) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030500 (Evidence)
Entrez Gene140919 (Evidence)
UniGene256618
DFCITC1579532, TC1649703, TC1725664
DoTSDT.50314935
NIA Mouse Gene IndexU008143
Consensus CDS ProjectCCDS39969.1
International Mouse Knockout Project StatusSlc17a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030500 Ensembl Gene Model | MGI Sequence Detail 49296 C57BL/6J ±  kb
transcript ENSMUST00000032710 Ensembl | MGI Sequence Detail 4319 Not Applicable 
polypeptide ENSMUSP00000032710 Ensembl | MGI Sequence Detail 582 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(566 from dbSNP Build 137)    SNPs within 2kb including multiple locations(568)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000014962 vesicular glutamate transporter 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213768 Shabel SJ, et al., Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment. Science. 2014 Sep 19;345(6203):1494-8
All references(165)
Other
accession IDs
MGI:1920305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory