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Polq Gene Detail
Summary
  • Symbol
    Polq
  • Name
    polymerase (DNA directed), theta
  • Synonyms
    A430110D14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155399
    NCBI Gene: 77782
  • Gene Overview
    MyGene.info: POLQ
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:37011786-37095417 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.32 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    467 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155399
protein coding gene Chr16:37011741-37095419 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022798
protein coding gene Chr16:35429924-35523995 (+)
A/J MGP_AJ_G0022763
protein coding gene Chr16:33690734-33774065 (+)
AKR/J MGP_AKRJ_G0022735
protein coding gene Chr16:34971122-35060112 (+)
BALB/cJ MGP_BALBcJ_G0022764
protein coding gene Chr16:33791658-33875325 (+)
C3H/HeJ MGP_C3HHeJ_G0022528
protein coding gene Chr16:35089164-35184563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023211
protein coding gene Chr16:36275610-36362283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020725
protein coding gene Chr16:34052493-34132666 (+)
CAST/EiJ MGP_CASTEiJ_G0022054
protein coding gene Chr16:35213628-35305793 (+)
CBA/J MGP_CBAJ_G0022499
protein coding gene Chr16:37857506-37949597 (+)
DBA/2J MGP_DBA2J_G0022631
protein coding gene Chr16:33582600-33669664 (+)
FVB/NJ MGP_FVBNJ_G0022606
protein coding gene Chr16:33617782-33702415 (+)
LP/J MGP_LPJ_G0022699
protein coding gene Chr16:35138610-35235275 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022625
protein coding gene Chr16:36927449-37014190 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023226
protein coding gene Chr16:34920830-35016107 (+)
PWK/PhJ MGP_PWKPhJ_G0021794
protein coding gene Chr16:33984769-34070341 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021625
protein coding gene Chr16:34841815-34931511 (+)
WSB/EiJ MGP_WSBEiJ_G0022098
protein coding gene Chr16:34983385-35070877 (+)



Homology
more
  • Human Ortholog
    POLQ, DNA polymerase theta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLQ, DNA polymerase theta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRO0327
  • Links
    NCBI Gene ID: 10721
    neXtProt AC: NX_O75417
    UniProt: O75417

  • Chr Location
    3q13.33; chr3:121431420-121546006 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32727
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: POLQ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals carrying a homozygous mutation at this locus display elevated levels of chromosomal damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034206 Ensembl Gene Model | MGI Sequence Detail 83632 C57BL/6J ±  kb
    transcript ENSMUST00000054034 Ensembl | MGI Sequence Detail 8552 Not Applicable  
    polypeptide ENSMUSP00000059757 Ensembl | MGI Sequence Detail 2544 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1925032
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:258323 Schimmel J, et al., Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells. EMBO J. 2017 Dec 15;36(24):3634-3649

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory