Ppp1r3a
Gene Detail

Symbol Name ID

Ppp1r3a protein phosphatase 1, regulatory (inhibitor) subunit 3A MGI:2153588

Synonyms

GM, RGL

Feature Type

protein coding gene

Genetic Map

Chromosome 6

6.31 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:14713822-14755274 bp, - strand From NCBI annotation of GRCm38   41453 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ppp1r3a

Human homologs

Human Homolog		PPP1R3A, protein phosphatase 1, regulatory subunit 3A
NCBI Gene ID		5506
neXtProt AC		NX_Q16821
Human Synonyms		GM, PP1G, PPP1R3
Human Chr (Location)		7q31.1; chr7:113516882-113559082 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PPP1R3A

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.

 
Human Diseases Modeled Using Mouse Ppp1r3a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	carbohydrate metabolic process, dephosphorylation, ...
Component	integral to membrane, membrane
Function	protein serine/threonine phosphatase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000042717 (Evidence)
Entrez Gene	140491 (Evidence)
UniGene	209429
DFCI	TC1587851
DoTS	DT.101723162
NIA Mouse Gene Index	U027056
Consensus CDS Project	CCDS19917.1
International Mouse Knockout Project Status	Ppp1r3a

Sequences

Length	Strain/Species
genomic	140491	NCBI Gene Model | MGI Sequence Detail	41453	C57BL/6J
transcript	NM_080464	RefSeq | MGI Sequence Detail	7120	C57BL/6
polypeptide	Q99MR9	UniProt | EBI | MGI Sequence Detail	1089	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(154 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005036	Putative phosphatase regulatory subunit
Protein Ontology	PR:000013124	protein phosphatase 1 regulatory subunit 3A

Graphical View of Protein Domain Structure

References

(Earliest) J:68370 Suzuki Y, et al., Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol. 2001 Apr;21(8):2683-94
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)