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Ppp1r3a Gene Detail
Summary
  • Symbol
    Ppp1r3a
  • Name
    protein phosphatase 1, regulatory (inhibitor) subunit 3A
  • Synonyms
    GM, RGL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153588
    NCBI Gene: 140491
  • Gene Overview
    MyGene.info: PPP1R3A
Location & Maps
more
  • Sequence Map
    Chr6:14713977-14755274 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41298 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 6.31 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP1R3A, protein phosphatase 1 regulatory subunit 3A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PPP1R3A, protein phosphatase 1 regulatory subunit 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GM, PP1G, PPP1R3
  • Links
    NCBI Gene ID: 5506
    neXtProt AC: NX_Q16821

  • Chr Location
    7q31.1; chr7:113876827-113919027 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ppp1r3a mouse models; 2 with human PPP1R3A associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
       Lipodystrophy, Familial Partial, Type 3; FPLD3   OMIM: 604367
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057098 VEGA Gene Model | MGI Sequence Detail 41298 C57BL/6J ±  kb
transcript OTTMUST00000140622 VEGA | MGI Sequence Detail 6965 Not Applicable  
polypeptide OTTMUSP00000073626 VEGA | MGI Sequence Detail 1089 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    161 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:68370 Suzuki Y, et al., Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol. 2001 Apr;21(8):2683-94
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory