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Ppp1r3a
Gene Detail
Symbol

Name
ID
Ppp1r3a
protein phosphatase 1, regulatory (inhibitor) subunit 3A
MGI:2153588
Synonyms
GM, RGL
Feature Type
protein coding gene
Genetic Map
Chromosome 6
6.31 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:14713822-14755274 bp, - strand
From NCBI annotation of GRCm38

  41453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Ppp1r3a

Human
homologs
Human Homolog PPP1R3A, protein phosphatase 1, regulatory subunit 3A
NCBI Gene ID 5506
neXtProt AC  NX_Q16821
Human Synonyms  GM, PP1G, PPP1R3
Human Chr (Location)  7q31.1; chr7:113876827-113919027 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PPP1R3A
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.
 
Human Diseases Modeled Using Mouse Ppp1r3a (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ppp1r3a interacts with 409 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process carbohydrate metabolic process, dephosphorylation, ...
Component integral component of membrane, membrane
Function protein serine/threonine phosphatase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000042717 (Evidence)
Entrez Gene140491 (Evidence)
UniGene209429
DFCITC1587851
DoTSDT.101723162
NIA Mouse Gene IndexU027056
Consensus CDS ProjectCCDS19917.1
International Mouse Knockout Project StatusPpp1r3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 140491 NCBI Gene Model | MGI Sequence Detail 41453 C57BL/6J ±  kb
transcript NM_080464 RefSeq | MGI Sequence Detail 7120 C57BL/6 
polypeptide Q99MR9 UniProt | EBI | MGI Sequence Detail 1089 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005036 Putative phosphatase regulatory subunit
Protein Ontology PR:000013124 protein phosphatase 1 regulatory subunit 3A
Graphical View of Protein Domain Structure
References
(Earliest) J:68370 Suzuki Y, et al., Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol. 2001 Apr;21(8):2683-94
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory