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Ppp1r3a Gene Detail
Summary
  • Symbol
    Ppp1r3a
  • Name
    protein phosphatase 1, regulatory subunit 3A
  • Synonyms
    GM, RGL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153588
    NCBI Gene: 140491
  • Gene Overview
    MyGene.info: PPP1R3A
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:14713977-14755274 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 6.31 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153588
protein coding gene Chr6:14713822-14755274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030463
protein coding gene Chr6:11839806-11886110 (-)
A/J MGP_AJ_G0030436
protein coding gene Chr6:11362851-11405463 (-)
AKR/J MGP_AKRJ_G0030363
protein coding gene Chr6:11797517-11843207 (-)
BALB/cJ MGP_BALBcJ_G0030445
protein coding gene Chr6:11412610-11455784 (-)
C3H/HeJ MGP_C3HHeJ_G0030159
protein coding gene Chr6:11672356-11715284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030900
protein coding gene Chr6:12270836-12313529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028111
protein coding gene Chr6:10505287-10545359 (-)
CAST/EiJ MGP_CASTEiJ_G0029561
protein coding gene Chr6:11528911-11572342 (-)
CBA/J MGP_CBAJ_G0030137
protein coding gene Chr6:12630351-12677272 (-)
DBA/2J MGP_DBA2J_G0030281
protein coding gene Chr6:11305116-11346914 (-)
FVB/NJ MGP_FVBNJ_G0030235
protein coding gene Chr6:11192526-11233888 (-)
LP/J MGP_LPJ_G0030368
protein coding gene Chr6:11923131-11965871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030271
protein coding gene Chr6:13469447-13546101 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030930
protein coding gene Chr6:11662972-11704982 (-)
PWK/PhJ MGP_PWKPhJ_G0029275
protein coding gene Chr6:10991619-11033032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029111
protein coding gene Chr6:11525775-11567349 (-)
WSB/EiJ MGP_WSBEiJ_G0029637
protein coding gene Chr6:11594481-11640226 (-)



Homology
more
  • Human Ortholog
    PPP1R3A, protein phosphatase 1 regulatory subunit 3A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PPP1R3A, protein phosphatase 1 regulatory subunit 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GM, PP1G, PPP1R3
  • Links
    NCBI Gene ID: 5506
    neXtProt AC: NX_Q16821
    UniProt: Q16821

  • Chr Location
    7q31.1; chr7:113876827-113919094 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ppp1r3a mouse models; 1 with human PPP1R3A associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042717 Ensembl Gene Model | MGI Sequence Detail 41298 C57BL/6J ±  kb
transcript ENSMUST00000045096 Ensembl | MGI Sequence Detail 6965 Not Applicable  
polypeptide ENSMUSP00000049054 Ensembl | MGI Sequence Detail 1089 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:68370 Suzuki Y, et al., Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol. 2001 Apr;21(8):2683-94
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory