Hnmt
Gene Detail

Symbol Name ID

Hnmt histamine N-methyltransferase MGI:2153181

Synonyms

1500031F01Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

16.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:24002910-24049394 bp, - strand From VEGA annotation of GRCm38   46485 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5032  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histamine N-methyltransferase
Gene Tree: Hnmt

Human homologs

Human Homolog		HNMT, histamine N-methyltransferase
NCBI Gene ID		3176
neXtProt AC		NX_P50135
Human Synonyms		HMT, HNMT-S1, HNMT-S2
Human Chr (Location)		2q22.1; chr2:137964238-138016364 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human HNMT

Alleles and phenotypes

All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	methylation, regulation of neurotransmitter levels
Component	cytoplasm, extracellular vesicular exosome, ...
Function	histamine N-methyltransferase activity, methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011800 (Evidence)
Ensembl Gene Model	ENSMUSG00000026986 (Evidence)
Entrez Gene	140483 (Evidence)
UniGene	33120
DFCI	TC1581113
DoTS	DT.101140822, DT.101366246, DT.489407
NIA Mouse Gene Index	U022362
EC	2.1.1.8
Consensus CDS Project	CCDS15731.1
International Mouse Knockout Project Status	Hnmt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011800	VEGA Gene Model | MGI Sequence Detail	46485	C57BL/6J
transcript	OTTMUST00000027697	VEGA | MGI Sequence Detail	1656	Not Applicable
polypeptide	OTTMUSP00000012588	VEGA | MGI Sequence Detail	295	Not Applicable

All sequences(43) RefSeq(6) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)    SNPs within 2kb including multiple locations(112)

Protein-related information

Resource	ID	Description
InterPro	IPR016673	Histamine N-methyltransferase
Protein Ontology	PR:000008656	histamine N-methyltransferase

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Other accession IDs

MGI:1923597, MGI:2139051