Hnmt MGI Mouse Gene Detail - MGI:2153181 - histamine N-methyltransferase

Symbol

Hnmt
Name

histamine N-methyltransferase
Synonyms

1500031F01Rik

Feature Type

protein coding gene
IDs

MGI:2153181
NCBI Gene: 140483
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:23892922-23939406 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 16.06 cM
Mapping Data

3 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153181	protein coding gene	Chr2:23892922-23939756 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025401	protein coding gene	Chr2:21779431-21827721 (-)
A/J	MGP_AJ_G0025379	protein coding gene	Chr2:20936087-20982482 (-)
AKR/J	MGP_AKRJ_G0025348	protein coding gene	Chr2:21629068-21681247 (-)
BALB/cJ	MGP_BALBcJ_G0025374	protein coding gene	Chr2:21040733-21090626 (-)
C3H/HeJ	MGP_C3HHeJ_G0025135	protein coding gene	Chr2:21582426-21631099 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025818	protein coding gene	Chr2:22447831-22496543 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023230	protein coding gene	Chr2:19894052-19935248 (-)
CAST/EiJ	MGP_CASTEiJ_G0024598	protein coding gene	Chr2:21454269-21497679 (-)
CBA/J	MGP_CBAJ_G0025113	protein coding gene	Chr2:23283670-23339649 (-)
DBA/2J	MGP_DBA2J_G0025246	protein coding gene	Chr2:20817608-20861366 (-)
FVB/NJ	MGP_FVBNJ_G0025208	protein coding gene	Chr2:20543713-20589545 (-)
LP/J	MGP_LPJ_G0025332	protein coding gene	Chr2:21709597-21757196 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025239	protein coding gene	Chr2:23455403-23505709 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025877	protein coding gene	Chr2:21575168-21621235 (-)
PWK/PhJ	MGP_PWKPhJ_G0024347	protein coding gene	Chr2:20600186-20649666 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024147	protein coding gene	Chr2:21675208-21719906 (-)
WSB/EiJ	MGP_WSBEiJ_G0024668	protein coding gene	Chr2:21669005-21708524 (-)

Human Ortholog

HNMT, histamine N-methyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNMT, histamine N-methyltransferase
Synonyms

HMT, HNMT-S1, HNMT-S2, MRT51
Links

HGNC:5028

NCBI Gene ID: 3176

neXtProt AC: NX_P50135

UniProt: P50135
Chr Location

2q22.1; chr2:137964068-138016364 (+) GRCh38.p7

Alliance of Genome Resources

Hnmt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HNMT
Protein SuperFamily

HHMT
Gene Tree

Hnmt

Diseases

1 with human HNMT associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 EFO:0000270 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a knock-out allele exhibit elevated histamine levels in the brain, increased aggression, hypoactivity and altered sleep-wake cycle.

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

94
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnmt

ZFIN hnmt

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Hnmt interacts with 164 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS15731.1

Ensembl

ENSMUSG00000026986 (Evidence)
NCBI Gene

140483

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026986	Ensembl Gene Model \| MGI Sequence Detail	46485	C57BL/6J	± kb
transcript	ENSMUST00000114498	Ensembl \| MGI Sequence Detail	1632	Not Applicable
polypeptide	ENSMUSP00000110142	Ensembl \| MGI Sequence Detail	295	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008656 histamine N-methyltransferase

(term hierarchy)
EC

2.1.1.8
InterPro Domains

IPR016673 Histamine N-methyltransferase-like

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 23

cDNA 23

Microarray probesets 3

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MGI:1923597, MGI:2139051

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:324455 Otsuka R, et al., Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice. Neuropharmacology. 2022 Jul 1;212:109065

TSS for Hnmt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22902	Chr2:23939420-23939431 (-)	-20 bp
Tssr22901	Chr2:23939401-23939412 (-)	-1 bp
Tssr22900	Chr2:23939368-23939392 (-)	26 bp
Tssr22899	Chr2:23938869-23938880 (-)	531 bp
Tssr22898	Chr2:23938840-23938858 (-)	557 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20