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Hnmt
Gene Detail
Symbol

Name
ID
Hnmt
histamine N-methyltransferase
MGI:2153181
Synonyms
1500031F01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:24002910-24049394 bp, - strand
From VEGA annotation of GRCm38

  46485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5032  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HNMT
Protein SuperFamily: histamine N-methyltransferase
Gene Tree: Hnmt

Human
homologs
HNMT, histamine N-methyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3176
neXtProt AC: NX_P50135

Human Synonyms: HMT, HNMT-S1, HNMT-S2

Human Chr (Location): 2q22.1; chr2:137964238-138016364 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HNMT

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hnmt interacts with 164 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process brain development, methylation, ...
Component cytoplasm, extracellular exosome, ...
Function histamine N-methyltransferase activity, methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hnmt ; ZFIN hnmt    NEW 
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011800 (Evidence)
Ensembl Gene Model ENSMUSG00000026986 (Evidence)
Entrez Gene 140483 (Evidence)
UniGene 33120
DFCI TC1581113
DoTS DT.101140822, DT.489407, DT.101366246
NIA Mouse Gene Index U022362
EC 2.1.1.8
Consensus CDS Project CCDS15731.1
International Mouse Phenotyping Consortium Status Hnmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011800 VEGA Gene Model | MGI Sequence Detail 46485 C57BL/6J ±  kb
transcript OTTMUST00000027697 VEGA | MGI Sequence Detail 1656 Not Applicable 
polypeptide OTTMUSP00000012588 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)    SNPs within 2kb including multiple locations(112)
Protein-related
information
ResourceIDDescription
InterPro IPR016673 Histamine N-methyltransferase
Protein Ontology PR:000008656 histamine N-methyltransferase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:1923597, MGI:2139051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory