Hnmt MGI Mouse Gene Detail - MGI:2153181 - histamine N-methyltransferase

Hnmt Gene Detail

Symbol

Hnmt
Name

histamine N-methyltransferase
Synonyms

1500031F01Rik

Feature Type

protein coding gene
IDs

MGI:2153181
NCBI Gene: 140483
Gene Overview

MyGene.info: HNMT
Alliance

gene page

Sequence Map

Chr2:24002910-24049394 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

46485 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 16.06 cM
Mapping Data

3 experiments

Human Ortholog

HNMT, histamine N-methyltransferase

Vertebrate Orthologs

10

Human Ortholog

HNMT, histamine N-methyltransferase
Orthology source: HomoloGene, HGNC
Synonyms

HMT, HNMT-S1, HNMT-S2, MRT51
Links

HGNC:5028

NCBI Gene ID: 3176

neXtProt AC: NX_P50135

UniProt: P50135
Chr Location

2q22.1; chr2:137964068-138016364 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5032
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HNMT
Protein SuperFamily

histamine N-methyltransferase
Gene Tree

Hnmt

Diseases

1 with human HNMT associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 EFO:0000270 ICD10CM:J45 ICD10CM:J45.90 ICD10CM:J45.909 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a knock-out allele exhibit elevated histamine levels in the brain, increased aggression, hypoactivity and altered sleep-wake cycle.

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All GO Annotations

14
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

94
cDNA Data

21
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnmt

ZFIN hnmt

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Hnmt interacts with 164 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

33
RefSeq

6
UniProt

2
CCDS

CCDS15731.1
UniGene

33120

			Length	Strain/Species	Flank
genomic	OTTMUSG00000011800	VEGA Gene Model \| MGI Sequence Detail	46485	C57BL/6J	± kb
transcript	OTTMUST00000027699	VEGA \| MGI Sequence Detail	994	Not Applicable
polypeptide	OTTMUSP00000012590	VEGA \| MGI Sequence Detail	295	Not Applicable

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SNPs within 2kb

109 from dbSNP Build 142

RFLP

1

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UniProt

2 Sequences
Protein Ontology

PR:000008656 histamine N-methyltransferase

(term hierarchy)
EC

2.1.1.8
InterPro Domains

IPR016673 Histamine N-methyltransferase-like

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase

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All nucleic 22

cDNA 22

Microarray probesets 3

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MGI:1923597, MGI:2139051

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:253575 Naganuma F, et al., Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Sci Rep. 2017 Nov 21;7(1):15899

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/15/2018 MGI 6.12