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Elmo1
Gene Detail
Symbol

Name
ID
Elmo1
engulfment and cell motility 1
MGI:2153044
Synonyms
6330578D22Rik, C230095H21Rik, CED-12
Feature Type
protein coding gene
Genetic Map
Chromosome 13
7.21 cM, cytoband A3.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:20090596-20606528 bp, + strand
From VEGA annotation of GRCm38

  515933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Elmo1

Human
homologs
Human Homolog ELMO1, engulfment and cell motility 1
NCBI Gene ID 9844
neXtProt AC  NX_Q92556
Human Synonyms  CED12, CED-12, ELMO-1
Human Chr (Location)  7p14.1; chr7:36852906-37449326 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells.
 
Interactions
Elmo1 interacts with 337 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process actin cytoskeleton organization, actin filament-based process, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding, SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (184)    Tissues (54)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 182
RT-PCR 2
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000042551 (Evidence)
Ensembl Gene ModelENSMUSG00000041112 (Evidence)
Entrez Gene140580 (Evidence)
UniGene342392
DFCITC1581005, TC1588932, TC1591521, TC1609326, TC1633182, TC1716455
DoTSDT.101214908, DT.101718523, DT.101721461, DT.110971949, DT.487847, DT.91331002, DT.97397166
NIA Mouse Gene IndexU014588
Consensus CDS ProjectCCDS26265.1, CCDS36606.1
International Mouse Knockout Project StatusElmo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042551 VEGA Gene Model | MGI Sequence Detail 515933 C57BL/6J ±  kb
transcript OTTMUST00000112176 VEGA | MGI Sequence Detail 3639 Not Applicable 
polypeptide OTTMUSP00000062932 VEGA | MGI Sequence Detail 727 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(5345 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5347)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR024574 Domain of unknown function DUF3361
InterPro IPR006816 Engulfment/cell motility, ELMO
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007031 engulfment and cell motility protein 1
References
(Earliest) J:72091 Gumienny TL, et al., Ced-12/elmo, a novel member of the crkii/dock180/rac pathway, is required for phagocytosis and cell migration. Cell. 2001 Oct 5;107(1):27-41
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(44)
Other
accession IDs
MGI:2145189, MGI:2444821

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory