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Elmo1
Gene Detail
Symbol

Name
ID
Elmo1
engulfment and cell motility 1
MGI:2153044
Synonyms
6330578D22Rik, C230095H21Rik, CED-12
Feature Type
protein coding gene
Genetic Map
Chromosome 13
7.21 cM, cytoband A3.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:20090596-20606528 bp, + strand
From VEGA annotation of GRCm38

  515933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ELMO1
Gene Tree: Elmo1

Human
homologs
ELMO1, engulfment and cell motility 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9844
neXtProt AC: NX_Q92556

Human Synonyms: CED12, CED-12, ELMO-1

Human Chr (Location): 7p14.1; chr7:36852906-37449409 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Radiation induced(1) Targeted(3)
Genomic Mutations involving Elmo1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells.
 
Interactions
Elmo1 interacts with 336 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process actin cytoskeleton organization, actin filament-based process, ...
Component cytoplasm, guanyl-nucleotide exchange factor complex, ...
Function protein binding, SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (184)    Tissues (54)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 182
RT-PCR 2
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase elmo1 ; ZFIN elmo1    NEW 
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000042551 (Evidence)
Ensembl Gene Model ENSMUSG00000041112 (Evidence)
Entrez Gene 140580 (Evidence)
UniGene 342392
DFCI TC1581005, TC1588932, TC1591521, TC1609326, TC1633182, TC1716455
DoTS DT.101214908, DT.101718523, DT.101721461, DT.110971949, DT.487847, DT.91331002, DT.97397166
NIA Mouse Gene Index U014588
Consensus CDS Project CCDS26265.1, CCDS36606.1
International Mouse Phenotyping Consortium Status Elmo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042551 VEGA Gene Model | MGI Sequence Detail 515933 C57BL/6J ±  kb
transcript OTTMUST00000112176 VEGA | MGI Sequence Detail 3639 Not Applicable 
polypeptide OTTMUSP00000062932 VEGA | MGI Sequence Detail 727 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(5345 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5347)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR024574 Domain of unknown function DUF3361
InterPro IPR006816 Engulfment/cell motility, ELMO
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007031 engulfment and cell motility protein 1
References
(Earliest) J:72091 Gumienny TL, et al., Ced-12/elmo, a novel member of the crkii/dock180/rac pathway, is required for phagocytosis and cell migration. Cell. 2001 Oct 5;107(1):27-41
(Latest) J:222140 Lanoue V, et al., The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50
All references(45)
Other
accession IDs
MGI:2145189, MGI:2444821

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory