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Elmo1 Gene Detail
Summary
  • Symbol
    Elmo1
  • Name
    engulfment and cell motility 1
  • Synonyms
    6330578D22Rik, C230095H21Rik, CED-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153044
    NCBI Gene: 140580
  • Gene Overview
    MyGene.info: ELMO1
  • Alliance
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:20090596-20608353 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 7.21 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5313 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153044
protein coding gene Chr13:20090507-20608353 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020264
protein coding gene Chr13:17298946-17855013 (+)
A/J MGP_AJ_G0020221
protein coding gene Chr13:16984769-17504361 (+)
AKR/J MGP_AKRJ_G0020195
protein coding gene Chr13:17227536-17761593 (+)
BALB/cJ MGP_BALBcJ_G0020207
protein coding gene Chr13:17020116-17550137 (+)
C3H/HeJ MGP_C3HHeJ_G0020010
protein coding gene Chr13:17341752-17868080 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020651
protein coding gene Chr13:17941505-18490824 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018258
protein coding gene Chr13:15401292-15910656 (+)
CAST/EiJ MGP_CASTEiJ_G0019545
protein coding gene Chr13:17111528-17638420 (+)
CBA/J MGP_CBAJ_G0019974
protein coding gene Chr13:18588964-19138288 (+)
DBA/2J MGP_DBA2J_G0020093
protein coding gene Chr13:16597998-17110949 (+)
FVB/NJ MGP_FVBNJ_G0020075
protein coding gene Chr13:16258059-16775933 (+)
LP/J MGP_LPJ_G0020164
protein coding gene Chr13:17532318-18078876 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020113
protein coding gene Chr13:19015673-19549531 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020680
protein coding gene Chr13:17031666-17566083 (+)
PWK/PhJ MGP_PWKPhJ_G0019308
protein coding gene Chr13:16656233-17180894 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019114
protein coding gene Chr13:16093117-16626903 (+)
WSB/EiJ MGP_WSBEiJ_G0019604
protein coding gene Chr13:17093767-17638901 (+)



Homology
more
  • Human Ortholog
    ELMO1, engulfment and cell motility 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELMO1, engulfment and cell motility 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CED12, CED-12, ELMO-1
  • Links
    NCBI Gene ID: 9844
    neXtProt AC: NX_Q92556
    UniProt: Q92556

  • Chr Location
    7p14.2-p14.1; chr7:36852906-37449409 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56685
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELMO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 5 alleles in 5 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041112 Ensembl Gene Model | MGI Sequence Detail 517758 C57BL/6J ±  kb
    transcript ENSMUST00000072519 Ensembl | MGI Sequence Detail 5464 Not Applicable  
    polypeptide ENSMUSP00000072334 Ensembl | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 53
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145189, MGI:2444821
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:71411 Arkell RM, et al., Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse. Mamm Genome. 2001 Sep;12(9):687-94
    • Latest
      J:241653 McCauley HA, et al., De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFbeta-deficient squamous cell carcinoma from transition zones. Elife. 2017 Feb 21;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory