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Srgap3 Gene Detail
Summary
  • Symbol
    Srgap3
  • Name
    SLIT-ROBO Rho GTPase activating protein 3
  • Synonyms
    Arhgap14, D130026O08Rik, mKIAA0411
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152938
    NCBI Gene: 259302
  • Gene Overview
    MyGene.info: SRGAP3
Location & Maps
more
  • Sequence Map
    Chr6:112717971-112947266 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      229296 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.54 cM, cytoband E3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SRGAP3, SLIT-ROBO Rho GTPase activating protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SRGAP3, SLIT-ROBO Rho GTPase activating protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHGAP14, MEGAP, SRGAP2, WRP
  • Links
    NCBI Gene ID: 9901
    neXtProt AC: NX_O43295

  • Chr Location
    3p25.3; chr3:8980591-9362929 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Srgap3 mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    7
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Srgap3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit a reduction in spine density in the brain CA1 and cortical layers IV/V. Mice homozygous for a different knock-out allele exhibit a neurodevelopment disorder with schizophrenia-related intermediate phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022682 VEGA Gene Model | MGI Sequence Detail 229296 C57BL/6J ±  kb
transcript OTTMUST00000054370 VEGA | MGI Sequence Detail 8887 Not Applicable  
polypeptide OTTMUSP00000025951 VEGA | MGI Sequence Detail 1099 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2099 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 120
    cDNA 118
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1889839, MGI:2442214
References
more
  • Summaries
    All 38
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:72329 Wong K, et al., Signal transduction in neuronal migration. roles of gtpase activating proteins and the small gtpase cdc42 in the slit-robo pathway. Cell. 2001 Oct 19;107(2):209-21
  • Latest
    J:192640 Kim IH, et al., Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. J Biol Chem. 2012 Nov 9;287(46):39263-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory