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Srgap3
Gene Detail
Symbol

Name
ID
Srgap3
SLIT-ROBO Rho GTPase activating protein 3
MGI:2152938
Synonyms
Arhgap14, D130026O08Rik, mKIAA0411
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.54 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:112717971-112947266 bp, - strand
From VEGA annotation of GRCm38

  229296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Srgap3

Human
homologs
Human Homolog   SRGAP3, SLIT-ROBO Rho GTPase activating protein 3
NCBI Gene ID 9901
neXtProt AC  NX_O43295
Human Synonyms  ARHGAP14, MEGAP, SRGAP2, WRP
Human Chr (Location)  3p25.3; chr3:8980591-9249685 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Spontaneous(1) Targeted(3)
Genomic Mutations involving Srgap3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit a reduction in spine density in the brain CA1 and cortical layers IV/V. Mice homozygous for a different knock-out allele exhibit a neurodevelopment disorder with schizophrenia-related intermediate phenotypes.
 
Human Diseases Modeled in Mice Using Srgap3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Srgap3 interacts with 503 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of cell migration, positive regulation of Rac GTPase activity, ...
Component cytoplasm, intracellular
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (181)    Tissues (141)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 181
cDNA source data(117)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(120) cDNA(118) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022682 (Evidence)
Ensembl Gene ModelENSMUSG00000030257 (Evidence)
Entrez Gene259302 (Evidence)
UniGene236401
DFCITC1652574, TC1578101, TC1586243, TC1578402
DoTSDT.55161182, DT.481592, DT.101737401
NIA Mouse Gene IndexU027719
Consensus CDS ProjectCCDS39590.1
International Mouse Knockout Project StatusSrgap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022682 VEGA Gene Model | MGI Sequence Detail 229296 C57BL/6J ±  kb
transcript OTTMUST00000054370 VEGA | MGI Sequence Detail 8887 Not Applicable 
polypeptide OTTMUSP00000025951 VEGA | MGI Sequence Detail 1099 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(11) UniProt(11)
Polymorphisms
SNPs within 2kb(2098 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000015617 SLIT-ROBO Rho GTPase-activating protein 3
References
(Earliest) J:72329 Wong K, et al., Signal transduction in neuronal migration. roles of gtpase activating proteins and the small gtpase cdc42 in the slit-robo pathway. Cell. 2001 Oct 19;107(2):209-21
(Latest) J:192640 Kim IH, et al., Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. J Biol Chem. 2012 Nov 9;287(46):39263-74
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:1889839, MGI:2442214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory