Srgap3
Gene Detail

Symbol Name ID

Srgap3 SLIT-ROBO Rho GTPase activating protein 3 MGI:2152938

Synonyms

Arhgap14, D130026O08Rik, mKIAA0411

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.54 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:112717971-112947266 bp, - strand From VEGA annotation of GRCm38   229296 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Srgap3

Human homologs

Human Homolog		SRGAP3, SLIT-ROBO Rho GTPase activating protein 3
NCBI Gene ID		9901
neXtProt AC		NX_O43295
Human Synonyms		ARHGAP14, MEGAP, SRGAP2, WRP
Human Chr (Location)		3p25.3; chr3:9022275-9291369 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(7)
 

Mice homozygous for a knock-out allele exhibit a reduction in spine density in the brain CA1 and cortical layers IV/V. Mice homozygous for a different knock-out allele exhibit a neurodevelopment disorder with schizophrenia-related intermediate phenotypes.

 
Human Diseases Modeled Using Mouse Srgap3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	signal transduction
Component	intracellular
Function	GTPase activator activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (181)    Tissues (140)    Images (43)
Theiler Stages: 16, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	181

cDNA source data(117)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(120) cDNA(118) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022682 (Evidence)
Ensembl Gene Model	ENSMUSG00000030257 (Evidence)
Entrez Gene	259302 (Evidence)
UniGene	236401
DFCI	TC1578101, TC1578402, TC1586243, TC1652574
DoTS	DT.101737401, DT.481592, DT.55161182
NIA Mouse Gene Index	U027719
Consensus CDS Project	CCDS39590.1
International Mouse Knockout Project Status	Srgap3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022682	VEGA Gene Model | MGI Sequence Detail	229296	C57BL/6J
transcript	OTTMUST00000054370	VEGA | MGI Sequence Detail	8887	Not Applicable
polypeptide	OTTMUSP00000025951	VEGA | MGI Sequence Detail	1099	Not Applicable

All sequences(60) RefSeq(3) UniProt(6)

Polymorphisms

SNPs(1345 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001060	FCH domain
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR013315	Spectrin alpha chain, SH3 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000015617	SLIT-ROBO Rho GTPase-activating protein 3

References

(Earliest) J:72329 Wong K, et al., Signal transduction in neuronal migration. roles of gtpase activating proteins and the small gtpase cdc42 in the slit-robo pathway. Cell. 2001 Oct 19;107(2):209-21
(Latest) J:192640 Kim IH, et al., Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. J Biol Chem. 2012 Nov 9;287(46):39263-74
All references(41)

Other accession IDs

MGI:1889839, MGI:2442214