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Srgap1 Gene Detail
Summary
  • Symbol
    Srgap1
  • Name
    SLIT-ROBO Rho GTPase activating protein 1
  • Synonyms
    4930572H05Rik, Arhgap13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152936
    NCBI Gene: 117600
  • Gene Overview
    MyGene.info: SRGAP1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:121780991-122047315 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 69.96 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152936
protein coding gene Chr10:121780991-122047315 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017787
protein coding gene Chr10:125078958-125360404 (-)
A/J MGP_AJ_G0017762
protein coding gene Chr10:120077102-120358926 (-)
AKR/J MGP_AKRJ_G0017725
protein coding gene Chr10:123664104-123933347 (-)
BALB/cJ MGP_BALBcJ_G0017726
protein coding gene Chr10:120500172-120772711 (-)
C3H/HeJ MGP_C3HHeJ_G0017550
protein coding gene Chr10:123868514-124142903 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018181
protein coding gene Chr10:129326198-129601797 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015861
protein coding gene Chr10:114396312-114666455 (-)
CAST/EiJ MGP_CASTEiJ_G0017110
protein coding gene Chr10:124266035-124553482 (-)
CBA/J MGP_CBAJ_G0017519
protein coding gene Chr10:134588601-134876531 (-)
DBA/2J MGP_DBA2J_G0017625
protein coding gene Chr10:119211193-119484466 (-)
FVB/NJ MGP_FVBNJ_G0017620
protein coding gene Chr10:118201625-118477030 (-)
LP/J MGP_LPJ_G0017699
protein coding gene Chr10:125619232-125909292 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017648
protein coding gene Chr10:137119361-137417863 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018221
protein coding gene Chr10:123720465-124002378 (-)
PWK/PhJ MGP_PWKPhJ_G0016895
protein coding gene Chr10:119335602-119610758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016686
protein coding gene Chr10:122589173-122870784 (-)
WSB/EiJ MGP_WSBEiJ_G0017171
protein coding gene Chr10:123905661-124189003 (-)



Homology
more
  • Human Ortholog
    SRGAP1, SLIT-ROBO Rho GTPase activating protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRGAP1, SLIT-ROBO Rho GTPase activating protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGAP13, NMTC2
  • Links
    NCBI Gene ID: 57522
    neXtProt AC: NX_Q7Z6B7
    UniProt: Q7Z6B7

  • Chr Location
    12q14.2; chr12:63844372-64147863 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56898
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRGAP1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SRGAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 117600 NCBI Gene Model | MGI Sequence Detail 266325 C57BL/6J ±  kb
transcript NM_001081037 RefSeq | MGI Sequence Detail 7787 C57BL/6  
polypeptide Q91Z69 UniProt | EBI | MGI Sequence Detail 1062 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 2
Other
Accession IDs
less
MGI:1914994
References
more
  • Summaries
    All 29
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:240644 Fan X, et al., SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 Nov 17;1(19):e86934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory