Srgap1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Srgap1
SLIT-ROBO Rho GTPase activating protein 1
MGI:2152936

13 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Srgap1^{tm1a(KOMP)Wtsi}/Srgap1^{tm1a(KOMP)Wtsi} Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * C57BL/6J * C57BL/6N	abnormal glomerular filtration barrier function	J:333727
	absent podocyte slit diaphragm	J:333727
	albuminuria	J:333727
	decreased podocyte number	J:333727
	detached podocyte	J:333727
	dilated renal tubule	J:333727
	expanded mesangial matrix	J:333727
	glomerulosclerosis	J:333727
	increased mesangial cell number	J:333727
	podocyte foot process effacement	J:333727
	renal cast	J:333727
Srgap1^{tm1a(KOMP)Wtsi}/Srgap1^{tm1a(KOMP)Wtsi} Tg(NPHS2-cre)295Lbh/0 involves: C57BL/6 * C57BL/6N * SJL	albuminuria	J:333727
	glomerulosclerosis	J:333727
	increased mesangial cell number	J:333727
	increased susceptibility to injury	J:333727
	normal renal/urinary system phenotype	J:333727

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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