About   Help   FAQ
Ivns1abp
Gene Detail
Symbol

Name
ID
Ivns1abp
influenza virus NS1A binding protein
MGI:2152389
Synonyms
1190004M08Rik, 1700126I16Rik, HSPC068, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP
Feature Type
protein coding gene
Genetic Map
Chromosome 1
64.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:151344477-151364422 bp, + strand
From VEGA annotation of GRCm38

  19946 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Ivns1abp

Human
homologs
Human Homolog IVNS1ABP, influenza virus NS1A binding protein
NCBI Gene ID 10625
neXtProt AC  NX_Q9Y6Y0
Human Synonyms  FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1BP, NS1-BP
Human Chr (Location)  1q25.1-q31.1; chr1:185296388-185317339 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity.
 
Interactions
Ivns1abp interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process negative regulation of intrinsic apoptotic signaling pathway
Component cytoplasm, cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (327)    Tissues (50)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 327
cDNA source data(418)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(420) cDNA(420)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000049560 (Evidence)
Ensembl Gene ModelENSMUSG00000023150 (Evidence)
Entrez Gene117198 (Evidence)
UniGene33764
DFCITC1573979, TC1583658, TC1605075, TC1683838
DoTSDT.101177672, DT.101216468, DT.101275791, DT.101405139, DT.101405140, DT.536631, DT.94304395, DT.94373515, DT.97351715
NIA Mouse Gene IndexU000909
Consensus CDS ProjectCCDS15358.1, CCDS15359.1, CCDS35735.1
International Mouse Knockout Project StatusIvns1abp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049560 VEGA Gene Model | MGI Sequence Detail 19946 C57BL/6J ±  kb
transcript OTTMUST00000126311 VEGA | MGI Sequence Detail 3511 Not Applicable 
polypeptide OTTMUSP00000068326 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(11) UniProt(2)
Polymorphisms
SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR015916 Galactose oxidase, beta-propeller
InterPro IPR017096 Kelch-like protein, gigaxonin
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000009168 influenza virus NS1A-binding protein
References
(Earliest) J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
(Latest) J:191763 Guazzi P, et al., Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. PLoS One. 2012;7(9):e44705
All references(40)
Other
accession IDs
MGI:1916149, MGI:1920854, MGI:2138140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory