Ivns1abp MGI Mouse Gene Detail - MGI:2152389 - influenza virus NS1A binding protein

Symbol

Ivns1abp
Name

influenza virus NS1A binding protein
Synonyms

1190004M08Rik, 1700126I16Rik, HSPC068, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP

Feature Type

protein coding gene
IDs

MGI:2152389
NCBI Gene: 117198
Gene Overview

MyGene.info: IVNS1ABP
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:151344477-151364422 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 64.06 cM
Mapping Data

2 experiments

SNPs within 2kb

180 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152389	protein coding gene	Chr1:151344309-151364445 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0016579	protein coding gene	Chr1:156066619-156088672 (+)
A/J	MGP_AJ_G0016561	protein coding gene	Chr1:149763664-149783629 (+)
AKR/J	MGP_AKRJ_G0016526	protein coding gene	Chr1:154375665-154395671 (+)
BALB/cJ	MGP_BALBcJ_G0016521	protein coding gene	Chr1:150325527-150345466 (+)
C3H/HeJ	MGP_C3HHeJ_G0016346	protein coding gene	Chr1:154517442-154537398 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016982	protein coding gene	Chr1:161467203-161487148 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014691	protein coding gene	Chr1:142108885-142128955 (+)
CAST/EiJ	MGP_CASTEiJ_G0015925	protein coding gene	Chr1:153946628-153966296 (+)
CBA/J	MGP_CBAJ_G0016320	protein coding gene	Chr1:167145495-167165461 (+)
DBA/2J	MGP_DBA2J_G0016426	protein coding gene	Chr1:148813762-148833709 (+)
FVB/NJ	MGP_FVBNJ_G0016424	protein coding gene	Chr1:147266507-147286458 (+)
LP/J	MGP_LPJ_G0016497	protein coding gene	Chr1:157120369-157140280 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016450	protein coding gene	Chr1:174860670-174880620 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017018	protein coding gene	Chr1:154144086-154164040 (+)
PWK/PhJ	MGP_PWKPhJ_G0015711	protein coding gene	Chr1:147772336-147792573 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015498	protein coding gene	Chr1:152982716-153003715 (+)
WSB/EiJ	MGP_WSBEiJ_G0015988	protein coding gene	Chr1:154245569-154265525 (+)

Human Ortholog

IVNS1ABP, influenza virus NS1A binding protein

Vertebrate Orthologs

11

Human Ortholog

IVNS1ABP, influenza virus NS1A binding protein
Orthology source: HomoloGene, HGNC
Synonyms

ARA3, FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1BP, NS1-BP
Links

HGNC:16951

NCBI Gene ID: 10625

neXtProt AC: NX_Q9Y6Y0

UniProt: Q9Y6Y0
Chr Location

1q25.3; chr1:185292367-185317343 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31384
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: IVNS1ABP
Protein SuperFamily

kelch-like protein, gigaxonin type
Gene Tree

Ivns1abp

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Gene trapped

4
Targeted

2
Genomic Mutations

2 involving Ivns1abp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity.

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All GO Annotations

10
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

327
Tissues

50
cDNA Data

419
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IVNS1ABP

Xenbase ivns1abp

ZFIN ivns1abpa

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Ivns1abp interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

77
RefSeq

13
UniProt

3
CCDS

CCDS15358.1, CCDS15359.1, CCDS35735.1
UniGene

33764

Ensembl

ENSMUSG00000023150 (Evidence)
NCBI Gene

117198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023150	Ensembl Gene Model \| MGI Sequence Detail	19946	C57BL/6J	± kb
transcript	ENSMUST00000023918	Ensembl \| MGI Sequence Detail	3511	Not Applicable
polypeptide	ENSMUSP00000023918	Ensembl \| MGI Sequence Detail	642	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009168 influenza virus NS1A-binding protein

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR029849 Influenza virus NS1A-binding protein

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 421

cDNA 421

Microarray probesets 5

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MGI:1916149, MGI:1920854, MGI:2138140

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
Latest

J:191763 Guazzi P, et al., Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. PLoS One. 2012;7(9):e44705

TSS for Ivns1abp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9377	Chr1:151344010-151344033 (+)	-455 bp
Tssr9378	Chr1:151344448-151344458 (+)	-24 bp
Tssr9379	Chr1:151344472-151344530 (+)	24 bp
Tssr9380	Chr1:151344531-151344584 (+)	81 bp
Tssr9382	Chr1:151354985-151354991 (+)	10,511 bp
Tssr9385	Chr1:151363060-151363064 (+)	18,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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