Ivns1abp MGI Mouse Gene Detail - MGI:2152389 - influenza virus NS1A binding protein

Ivns1abp Gene Detail

Symbol

Ivns1abp
Name

influenza virus NS1A binding protein
Synonyms

1190004M08Rik, 1700126I16Rik, HSPC068, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP

Feature Type

protein coding gene
IDs

MGI:2152389
NCBI Gene: 117198
Gene Overview

MyGene.info: IVNS1ABP

Sequence Map

Chr1:151344477-151364422 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

19946 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 64.06 cM
Mapping Data

2 experiments

Human Ortholog

IVNS1ABP, influenza virus NS1A binding protein

Vertebrate Orthologs

11

Human Ortholog

IVNS1ABP, influenza virus NS1A binding protein
Orthology source: HomoloGene, HGNC
Synonyms

FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1BP, NS1-BP
Links

HGNC:16951

NCBI Gene ID: 10625

neXtProt AC: NX_Q9Y6Y0

UniProt: Q9Y6Y0
Chr Location

1q25.3; chr1:185292367-185317343 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31384
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: IVNS1ABP
Protein SuperFamily

kelch-like protein, gigaxonin type
Gene Tree

Ivns1abp

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Gene trapped

4
Targeted

2
Genomic Mutations

2 involving Ivns1abp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity.

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All GO Annotations

7
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

327
Tissues

50
cDNA Data

418
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IVNS1ABP

Xenbase ivns1abp

ZFIN ivns1abpa

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Ivns1abp interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

70
RefSeq

13
UniProt

3
CCDS

CCDS15358.1, CCDS15359.1, CCDS35735.1
UniGene

33764

			Length	Strain/Species	Flank
genomic	OTTMUSG00000049560	VEGA Gene Model \| MGI Sequence Detail	19946	C57BL/6J	± kb
transcript	OTTMUST00000126311	VEGA \| MGI Sequence Detail	3511	Not Applicable
polypeptide	OTTMUSP00000068326	VEGA \| MGI Sequence Detail	642	Not Applicable

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SNPs within 2kb

180 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000009168 influenza virus NS1A-binding protein

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR029849 Influenza virus NS1A-binding protein

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain

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All nucleic 420

cDNA 420

Microarray probesets 5

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MGI:1916149, MGI:1920854, MGI:2138140

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
Latest

J:191763 Guazzi P, et al., Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. PLoS One. 2012;7(9):e44705

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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