Ivns1abp
Gene Detail

Symbol

Name
ID

Ivns1abp
influenza virus NS1A binding protein
MGI:2152389

Synonyms

1190004M08Rik, 1700126I16Rik, HSPC068, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP

Feature Type

protein coding gene

Genetic Map

Chromosome 1
64.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:151344477-151364422 bp, + strand From VEGA annotation of GRCm38   19946 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:31384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Ivns1abp

Human
homologs

Human Homolog		IVNS1ABP, influenza virus NS1A binding protein
NCBI Gene ID		10625
neXtProt AC		NX_Q9Y6Y0
Human Synonyms		FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1BP, NS1-BP
Human Chr (Location)		1q25.1-q31.1; chr1:185296388-185317339 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity.

 

Interactions

Ivns1abp interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (6 annotations)

Process	negative regulation of intrinsic apoptotic signaling pathway
Component	actin cytoskeleton, cytoplasm, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (327)    Tissues (50)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	327

cDNA source data(418)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(420) cDNA(420)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000049560 (Evidence)
Ensembl Gene Model	ENSMUSG00000023150 (Evidence)
Entrez Gene	117198 (Evidence)
UniGene	33764
DFCI	TC1573979, TC1583658, TC1605075, TC1683838
DoTS	DT.97351715, DT.94373515, DT.101216468, DT.94304395, DT.101177672, DT.101275791, DT.536631, DT.101405139, DT.101405140
NIA Mouse Gene Index	U000909
Consensus CDS Project	CCDS15358.1, CCDS15359.1, CCDS35735.1
International Mouse Knockout Project Status	Ivns1abp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000049560	VEGA Gene Model | MGI Sequence Detail	19946	C57BL/6J
transcript	OTTMUST00000126311	VEGA | MGI Sequence Detail	3511	Not Applicable
polypeptide	OTTMUSP00000068326	VEGA | MGI Sequence Detail	642	Not Applicable

All sequences(82) RefSeq(11) UniProt(3)

Polymorphisms

SNPs within 2kb(172 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR011705	BTB/Kelch-associated
InterPro	IPR013069	BTB/POZ
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR015916	Galactose oxidase, beta-propeller
InterPro	IPR017096	Kelch-like protein, gigaxonin
InterPro	IPR006652	Kelch repeat type 1
InterPro	IPR015915	Kelch-type beta propeller
Protein Ontology	PR:000009168	influenza virus NS1A-binding protein

References

(Earliest) J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
(Latest) J:191763 Guazzi P, et al., Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. PLoS One. 2012;7(9):e44705
All references(41)

Other
accession IDs

MGI:1916149, MGI:1920854, MGI:2138140