Ivns1abp
Gene Detail

Symbol Name ID

Ivns1abp influenza virus NS1A binding protein MGI:2152389

Synonyms

1190004M08Rik, 1700126I16Rik, HSPC068, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP

Feature Type

protein coding gene

Genetic Map

Chromosome 1

64.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:151344498-151364445 bp, + strand From NCBI annotation of GRCm38   19948 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Ivns1abp

Human homologs

Human Homolog		IVNS1ABP, influenza virus NS1A binding protein
NCBI Gene ID		10625
neXtProt AC		NX_Q9Y6Y0
Human Synonyms		FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1BP, NS1-BP
Human Chr (Location)		1q25.1-q31.1; chr1:185296388-185317339 (-)  GRCh38

Alleles and phenotypes

All alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	negative regulation of intrinsic apoptotic signaling pathway
Component	cytoplasm, cytoskeleton, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (327)    Tissues (50)    Images (23)
Theiler Stages: 19, 23

Assay Type	Results
RNA in situ	327

cDNA source data(418)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(420) cDNA(420)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000023150 (Evidence)
Entrez Gene	117198 (Evidence)
UniGene	33764
DFCI	TC1573979, TC1583658, TC1605075, TC1683838
DoTS	DT.101177672, DT.101216468, DT.101275791, DT.101405139, DT.101405140, DT.536631, DT.94304395, DT.94373515, DT.97351715
NIA Mouse Gene Index	U000909
Consensus CDS Project	CCDS15358.1, CCDS15359.1, CCDS35735.1
International Mouse Knockout Project Status	Ivns1abp

Sequences

Length	Strain/Species
genomic	117198	NCBI Gene Model | MGI Sequence Detail	19948	C57BL/6J
transcript	NM_054102	RefSeq | MGI Sequence Detail	3513	C57BL/6
polypeptide	Q920Q8	UniProt | EBI | MGI Sequence Detail	642	Not Applicable

All sequences(66) RefSeq(11) UniProt(2)

Polymorphisms

SNPs within 2kb(173 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011705	BTB/Kelch-associated
InterPro	IPR013069	BTB/POZ
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR015916	Galactose oxidase, beta-propeller
InterPro	IPR017096	Kelch-like protein, gigaxonin
InterPro	IPR006652	Kelch repeat type 1
InterPro	IPR015915	Kelch-type beta propeller
Protein Ontology	PR:000009168	influenza virus NS1A-binding protein

Graphical View of Protein Domain Structure

References

(Earliest) J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
(Latest) J:191763 Guazzi P, et al., Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. PLoS One. 2012;7(9):e44705
All references(39)

Other accession IDs

MGI:1916149, MGI:1920854, MGI:2138140