About   Help   FAQ
Taf4a
Gene Detail
 Symbol
Name
ID
Taf4a
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
MGI:2152346
Synonyms 135kDa, Taf2c1, TAFII130, TAFII135
Feature Type protein coding gene
Genetic Map
Chromosome 2
102.42 cM, cytoband H4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:179912152-179975559 bp, - strand
From VEGA annotation of GRCm38

  63408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55723  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Taf4a

Human
homologs
Human Homolog TAF4, TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
NCBI Gene ID 6874
neXtProt AC  NX_O00268
Human Synonyms  TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Human Chr (Location)  20q13.33; chr20:61974798-62065810 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for deletions of this marker die embryonically sometime around E9.5. Conditional expression of this allele in the epidermis causes skin barrier defects and defects in hair growth.
 
Interactions
Taf4a interacts with 247 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process DNA-templated transcription, initiation, ovarian follicle development, ...
Component cytoplasm, MLL1 complex, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (18)   
Theiler Stages: 21, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 17
Northern blot 5
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016232 (Evidence)
Ensembl Gene ModelENSMUSG00000039117 (Evidence)
Entrez Gene228980 (Evidence)
UniGene235542
DFCITC1647113
DoTSDT.531577, DT.91410385
NIA Mouse Gene IndexU023753
Consensus CDS ProjectCCDS38373.1
International Mouse Knockout Project StatusTaf4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016232 VEGA Gene Model | MGI Sequence Detail 63408 C57BL/6J ±  kb
transcript OTTMUST00000038896 VEGA | MGI Sequence Detail 3329 Not Applicable 
polypeptide OTTMUSP00000017384 VEGA | MGI Sequence Detail 680 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(243 from dbSNP Build 137)    SNPs within 2kb including multiple locations(247)
Protein-related
information
ResourceIDDescription
InterPro IPR009072 Histone-fold
InterPro IPR003894 TAFH/NHR1
InterPro IPR007900 Transcription initiation factor TFIID component TAF4
Protein Ontology PR:000016027 transcription initiation factor TFIID subunit 4
References (Earliest) J:71679 Freiman RN, et al., Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7
(Latest) J:199361 Chen WY, et al., A TAF4 coactivator function for E proteins that involves enhanced TFIID binding. Genes Dev. 2013 Jul 15;27(14):1596-609
All references(43)
Other
accession IDs
MGI:2138960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory