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Taf4 Gene Detail
Summary
  • Symbol
    Taf4
  • Name
    TATA-box binding protein associated factor 4
  • Synonyms
    Taf2c1, Taf4a, TAFII130, TAFII135
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152346
    NCBI Gene: 228980
  • Gene Overview
    MyGene.info: TAF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:179912152-179976646 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64495 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 102.42 cM, cytoband H4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
  • Links
    NCBI Gene ID: 6874
    neXtProt AC: NX_O00268
    UniProt: O00268

  • Chr Location
    20q13.33; chr20:61974798-62065810 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55723
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TAF4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for deletions of this marker die embryonically sometime around E9.5. Conditional expression of this allele in the epidermis causes skin barrier defects and defects in hair growth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016232 VEGA Gene Model | MGI Sequence Detail 64495 C57BL/6J ±  kb
    transcript OTTMUST00000038896 VEGA | MGI Sequence Detail 4416 Not Applicable  
    polypeptide OTTMUSP00000017384 VEGA | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      241 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138960
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:71679 Freiman RN, et al., Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7
    • Latest
      J:245730 Bardot P, et al., The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory