About   Help   FAQ
Taf4 Gene Detail
Summary
  • Symbol
    Taf4
  • Name
    TATA-box binding protein associated factor 4
  • Synonyms
    Taf2c1, Taf4a, TAFII130, TAFII135
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152346
    NCBI Gene: 228980
  • Gene Overview
    MyGene.info: TAF4
Location & Maps
more
  • Sequence Map
    Chr2:179912152-179976646 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64495 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
  • Links
    NCBI Gene ID: 6874
    neXtProt AC: NX_O00268

  • Chr Location
    20q13.33; chr20:61974798-62065810 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55723
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TAF4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    12
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for deletions of this marker die embryonically sometime around E9.5. Conditional expression of this allele in the epidermis causes skin barrier defects and defects in hair growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016232 VEGA Gene Model | MGI Sequence Detail 64495 C57BL/6J ±  kb
transcript OTTMUST00000038896 VEGA | MGI Sequence Detail 4416 Not Applicable  
polypeptide OTTMUSP00000017384 VEGA | MGI Sequence Detail 1042 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    241 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009072 Histone-fold
    IPR003894 TAFH/NHR1
    IPR007900 Transcription initiation factor TFIID component TAF4
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138960
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:71679 Freiman RN, et al., Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7
  • Latest
    J:228779 Alpern D, et al., TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Elife. 2014;3:e03613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory