Tirap
Gene Detail

Symbol Name ID

Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein MGI:2152213

Synonyms

C130027E04Rik, Mal, Mal, MyD88-adapter-like, wyatt

Feature Type

protein coding gene

Genetic Map

Chromosome 9

19.99 cM, cytoband A5.3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:35184551-35200291 bp, - strand From VEGA annotation of GRCm38   15741 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: toll-interleukin 1 receptor domain-containing adaptor protein, Tirap type
Gene Tree: Tirap

Human homologs

Human Homolog		TIRAP, toll-interleukin 1 receptor (TIR) domain containing adaptor protein
NCBI Gene ID		114609
neXtProt AC		NX_P58753
Human Synonyms		BACTS1, Mal, MyD88-2, wyatt
Human Chr (Location)		11q24.2; chr11:126152982-126164828 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human TIRAP

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(5) Chemically induced(1)
 

Mutations in this gene lead to impaired cytokine secretion in response to TLR2 and TLR4 ligands. Homozygous null mice may also show low serum IgG3 levels, a reduced response to attenuated yellow fever vaccine, high susceptibility to bacterial infection, and altered response to myocardial infarction.

 

Gene Ontology (GO) classifications

All GO classifications: (62 annotations)

Process	3'-UTR-mediated mRNA stabilization, activation of JUN kinase activity, ...
Component	cytoplasm, endocytic vesicle, ...
Function	phosphatidylinositol-4,5-bisphosphate binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(38)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000042147 (Evidence)
Ensembl Gene Model	ENSMUSG00000032041 (Evidence)
Entrez Gene	117149 (Evidence)
UniGene	23987
DoTS	DT.486592, DT.87047736, DT.97391118, DT.97391124
NIA Mouse Gene Index	U030662
Consensus CDS Project	CCDS40575.2
International Mouse Knockout Project Status	Tirap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042147	VEGA Gene Model | MGI Sequence Detail	15741	C57BL/6J
transcript	OTTMUST00000110587	VEGA | MGI Sequence Detail	4589	Not Applicable
polypeptide	OTTMUSP00000061721	VEGA | MGI Sequence Detail	249	Not Applicable

All sequences(69) RefSeq(8) UniProt(7)

Polymorphisms

SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017279	Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology	PR:000001751	toll/interleukin-1 receptor domain-containing adapter protein
Protein Ontology	PR:000027173	toll/interleukin-1 receptor domain-containing adapter protein (mouse)

References

(Earliest) J:71392 Fitzgerald KA, et al., Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83
(Latest) J:193330 Gandhi A, et al., Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):430-8
All references(96)

Other accession IDs

MGI:2142915