Mutations in this gene lead to impaired cytokine secretion in response to TLR2 and TLR4 ligands. Homozygous null mice may also show low serum IgG3 levels, a reduced response to attenuated yellow fever vaccine, high susceptibility to bacterial infection, and altered response to myocardial infarction.
|VEGA Gene Model||OTTMUSG00000042147 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000032041 (Evidence)|
|Entrez Gene||117149 (Evidence)|
|DoTS||DT.87047736, DT.486592, DT.97391118, DT.97391124|
|NIA Mouse Gene Index||U030662|
|Consensus CDS Project||CCDS40575.2|
|International Mouse Phenotyping Consortium Status||Tirap|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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