About   Help   FAQ
Tirap Gene Detail
Summary
  • Symbol
    Tirap
  • Name
    toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  • Synonyms
    C130027E04Rik, Mal, Mal, MyD88-adapter-like, wyatt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152213
    NCBI Gene: 117149
Location & Maps
more
  • Sequence Map
    Chr9:35184551-35200291 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15741 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TIRAP, toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TIRAP, toll-interleukin 1 receptor (TIR) domain containing adaptor protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BACTS1, Mal, MyD88-2, wyatt
  • Links
    NCBI Gene ID: 114609
    neXtProt AC: NX_P58753

  • Chr Location
    11q24.2; chr11:126281893-126294933 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human TIRAP associations

Human Disease Mouse Models
       Bacteremia, Susceptibility to, 1; BACTS1   OMIM: 614382
Invasive Pneumococcal Disease, Recurrent Isolated, 1; IPD1   OMIM: 610799
Malaria, Susceptibility to   OMIM: 611162
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Gene trapped
    5
  • Targeted
    3
  • Incidental Mutations
Mutations in this gene lead to impaired cytokine secretion in response to TLR2 and TLR4 ligands. Homozygous null mice may also show low serum IgG3 levels, a reduced response to attenuated yellow fever vaccine, high susceptibility to bacterial infection, and altered response to myocardial infarction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042147 VEGA Gene Model | MGI Sequence Detail 15741 C57BL/6J ±  kb
transcript OTTMUST00000110587 VEGA | MGI Sequence Detail 4589 Not Applicable  
polypeptide OTTMUSP00000061721 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    163 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
  • InterPro Domains
    IPR017279 Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Molecular
Reagents
less
  • All nucleic 38
    cDNA 38

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142915
References
more
  • Summaries
    All 100
    Developmental Gene Expression 1
    Gene Ontology 17
    Phenotypes 54
  • Earliest
    J:71392 Fitzgerald KA, et al., Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83
  • Latest
    J:212589 Kennedy CL, et al., Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis. Oncogene. 2014 May 8;33(19):2540-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory