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Tirap
Gene Detail
 Symbol
Name
ID
Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
MGI:2152213
Synonyms C130027E04Rik, Mal, Mal, MyD88-adapter-like, wyatt
Feature Type protein coding gene
Genetic Map
Chromosome 9
19.99 cM, cytoband A5.3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:35184551-35200291 bp, - strand
From VEGA annotation of GRCm38

  15741 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: toll-interleukin 1 receptor domain-containing adaptor protein, Tirap type
Gene Tree: Tirap

Human
homologs
Human Homolog TIRAP, toll-interleukin 1 receptor (TIR) domain containing adaptor protein
NCBI Gene ID 114609
neXtProt AC  NX_P58753
Human Synonyms  BACTS1, Mal, MyD88-2, wyatt
Human Chr (Location)  11q24.2; chr11:126282905-126294933 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human TIRAP
Alleles
and
phenotypes
All alleles(9) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene lead to impaired cytokine secretion in response to TLR2 and TLR4 ligands. Homozygous null mice may also show low serum IgG3 levels, a reduced response to attenuated yellow fever vaccine, high susceptibility to bacterial infection, and altered response to myocardial infarction.
 
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process 3'-UTR-mediated mRNA stabilization, activation of JUN kinase activity, ...
Component cytoplasm, endocytic vesicle, ...
Function phosphatidylinositol-4,5-bisphosphate binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) cDNA(38)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000042147 (Evidence)
Ensembl Gene ModelENSMUSG00000032041 (Evidence)
Entrez Gene117149 (Evidence)
UniGene23987
DoTSDT.486592, DT.87047736, DT.97391118, DT.97391124
NIA Mouse Gene IndexU030662
Consensus CDS ProjectCCDS40575.2
International Mouse Knockout Project StatusTirap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042147 VEGA Gene Model | MGI Sequence Detail 15741 C57BL/6J ±  kb
transcript OTTMUST00000110587 VEGA | MGI Sequence Detail 4589 Not Applicable 
polypeptide OTTMUSP00000061721 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017279 Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001751 toll/interleukin-1 receptor domain-containing adapter protein
References (Earliest) J:71392 Fitzgerald KA, et al., Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83
(Latest) J:209813 Ferrero MC, et al., Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages. Infect Immun. 2014 Feb;82(2):626-39
All references(100)
Other
accession IDs
MGI:2142915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory