Tirap Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
MGI:2152213

13 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tirap^m1Btlr/Tirap^m1Btlr C57BL/6J-Tirap^m1Btlr	abnormal interferon secretion	J:133618
Tirap^m1Btlr/Tirap^m1Btlr C57BL/6J-Tirap^m1Btlr	decreased tumor necrosis factor secretion	J:133618
Tirap^tm1Aki/Tirap^tm1Aki B6.129P2-Tirap^tm1Aki	abnormal dendritic cell physiology	J:118954
	decreased interleukin-6 secretion	J:118954
	decreased interleukin-12b secretion	J:118954
Tirap^tm1Aki/Tirap^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal cytokine secretion	J:111205
	abnormal level of surface class II molecules	J:111205
	decreased IgG3 level	J:137066
Tirap^tm1Medz/Tirap^tm1Medz involves: 129S1/Sv	abnormal macrophage physiology	J:96018
	abnormal response to cardiac infarction	J:119941
	increased susceptibility to bacterial infection	J:96018
	increased susceptibility to induced morbidity/mortality	J:96018
Tirap^tm1Medz/Tirap^tm1Medz involves: 129S1/Sv * C57BL/6	abnormal dendritic cell physiology	J:96773
	abnormal macrophage physiology	J:96773
	decreased B cell proliferation	J:96773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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