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Cnnm2
Gene Detail
 Symbol
Name
ID
Cnnm2
cyclin M2
MGI:2151054
Synonyms Acdp2
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:46761609-46878580 bp, + strand
From NCBI annotation of GRCm38

  116972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9761  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cnnm2

Human
homologs
Human Homolog CNNM2, cyclin and CBS domain divalent metal cation transport mediator 2
NCBI Gene ID 54805
neXtProt AC  NX_Q9H8M5
Human Synonyms  ACDP2
Human Chr (Location)  10q24.32; chr10:102918318-103078587 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CNNM2
Mutations,
alleles, and
phenotypes
All mutations/alleles(117) : Gene trapped(116) Targeted(1)
Incidental mutations (data from APF )
Interactions
Cnnm2 interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process ion transport, magnesium ion homeostasis, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (28)    Tissues (28)    Images (8)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 28
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000064105 (Evidence)
Entrez Gene94219 (Evidence)
Consensus CDS ProjectCCDS50459.1, CCDS50460.1
International Mouse Knockout Project StatusCnnm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94219 NCBI Gene Model | MGI Sequence Detail 116972 C57BL/6J ±  kb
transcript NM_033569 RefSeq | MGI Sequence Detail 3330 C57BL/6 
polypeptide Q3TWN3 UniProt | EBI | MGI Sequence Detail 875 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(786 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR000644 Cystathionine beta-synthase, core
InterPro IPR002550 Domain of unknown function DUF21
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000005644 metal transporter CNNM2
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:171500 Stuiver M, et al., CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet. 2011 Mar 11;88(3):333-43
All references(34)
Other
accession IDs
MGI:2147641, MGI:2147691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory