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Tmc2 Gene Detail
Summary
  • Symbol
    Tmc2
  • Name
    transmembrane channel-like gene family 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151017
    NCBI Gene: 192140
  • Gene Overview
    MyGene.info: TMC2
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:130195194-130264445 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151017
protein coding gene Chr2:130195194-130265480 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026496
protein coding gene Chr2:133637746-133711666 (+)
A/J MGP_AJ_G0026460
protein coding gene Chr2:128232634-128303359 (+)
AKR/J MGP_AKRJ_G0026435
protein coding gene Chr2:131906016-131983475 (+)
BALB/cJ MGP_BALBcJ_G0026472
protein coding gene Chr2:128590493-128660607 (+)
C3H/HeJ MGP_C3HHeJ_G0026215
protein coding gene Chr2:132359623-132438110 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026917
protein coding gene Chr2:137778685-137854621 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024294
protein coding gene Chr2:122977498-123045833 (+)
CAST/EiJ MGP_CASTEiJ_G0025676
protein coding gene Chr2:132610934-132688225 (+)
CBA/J MGP_CBAJ_G0026195
protein coding gene Chr2:142884156-142959588 (+)
DBA/2J MGP_DBA2J_G0026329
protein coding gene Chr2:127622082-127691320 (+)
FVB/NJ MGP_FVBNJ_G0026293
protein coding gene Chr2:126243086-126312653 (+)
LP/J MGP_LPJ_G0026434
protein coding gene Chr2:133891316-133972349 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026313
protein coding gene Chr2:146738994-146811363 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026972
protein coding gene Chr2:131884555-131955754 (+)
PWK/PhJ MGP_PWKPhJ_G0025412
protein coding gene Chr2:127174767-127244931 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025214
protein coding gene Chr2:131001141-131074643 (+)
WSB/EiJ MGP_WSBEiJ_G0025750
protein coding gene Chr2:132805298-132876196 (+)



Homology
more
  • Human Ortholog
    TMC2, transmembrane channel like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMC2, transmembrane channel like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf145
  • Links
    NCBI Gene ID: 117532
    neXtProt AC: NX_Q8TDI7
    UniProt: Q8TDI7

  • Chr Location
    20p13; chr20:2536607-2642185 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 25877
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TMC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display normal hearing and motor behavior. Cochlear hair cells show partial resistance to gentamicin induced toxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060332 Ensembl Gene Model | MGI Sequence Detail 69252 C57BL/6J ±  kb
transcript ENSMUST00000077988 Ensembl | MGI Sequence Detail 3216 Not Applicable  
polypeptide ENSMUSP00000077139 Ensembl | MGI Sequence Detail 888 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 3
    Primer pair 4

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:255532 Gao X, et al., Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 Jan 11;553(7687):217-221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory