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Mta1
Gene Detail
Symbol

Name
ID
Mta1
metastasis associated 1
MGI:2150037
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.57 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:113098278-113137206 bp, + strand
From VEGA annotation of GRCm38

  38929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mta1

Human
homologs
Human Homolog MTA1, metastasis associated 1
NCBI Gene ID 9112
neXtProt AC  NX_Q13330
Human Chr (Location)  14q32.3; chr14:105419849-105470725 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(39) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to ionizing radiation and increased retinal cell proliferation at E14.5.
 
Interactions
Mta1 interacts with 92 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process circadian regulation of gene expression, double-strand break repair, ...
Component cytoplasm, endoplasmic reticulum, ...
Function chromatin binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (51)    Tissues (51)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(102) Genomic(1) cDNA(100) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017198 (Evidence)
Ensembl Gene ModelENSMUSG00000021144 (Evidence)
Entrez Gene116870 (Evidence)
UniGene212577
DFCITC1575508, TC1589598, TC1597966, TC1639466
DoTSDT.55137427, DT.60118730, DT.99857603, DT.99857605
NIA Mouse Gene IndexU014465, U291729
Consensus CDS ProjectCCDS36574.1
International Mouse Knockout Project StatusMta1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017198 VEGA Gene Model | MGI Sequence Detail 38929 C57BL/6J ±  kb
transcript OTTMUST00000041646 VEGA | MGI Sequence Detail 2826 Not Applicable 
polypeptide OTTMUSP00000018706 VEGA | MGI Sequence Detail 715 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(66) UniProt(23)
Polymorphisms
SNPs within 2kb(253 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR000949 ELM2 domain
InterPro IPR009057 Homeodomain-like
InterPro IPR017884 SANT domain
InterPro IPR001005 SANT/Myb domain
InterPro IPR000679 Zinc finger, GATA-type
Protein Ontology PR:000010707 metastasis-associated protein MTA1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:213644 Liu J, et al., The subcellular distribution and function of MTA1 in cancer differentiation. Oncotarget. 2014 Jul 15;5(13):5153-64
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory