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Mta1 Gene Detail
Summary
  • Symbol
    Mta1
  • Name
    metastasis associated 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150037
    NCBI Gene: 116870
  • Gene Overview
    MyGene.info: MTA1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113098278-113137206 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.57 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150037
protein coding gene Chr12:113098278-113137206 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020171
protein coding gene Chr12:115592924-115633257 (+)
A/J MGP_AJ_G0020127
protein coding gene Chr12:111116819-111155407 (+)
AKR/J MGP_AKRJ_G0020102
protein coding gene Chr12:114347997-114386620 (+)
BALB/cJ MGP_BALBcJ_G0020112
protein coding gene Chr12:111559300-111620922 (+)
C3H/HeJ MGP_C3HHeJ_G0019914
protein coding gene Chr12:114871128-114908564 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020557
protein coding gene Chr12:119141486-119178646 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018171
protein coding gene Chr12:107551065-107588742 (+)
CAST/EiJ MGP_CASTEiJ_G0019454
protein coding gene Chr12:109706751-109752926 (+)
CBA/J MGP_CBAJ_G0019881
protein coding gene Chr12:123678289-123746637 (+)
DBA/2J MGP_DBA2J_G0019998
protein coding gene Chr12:110617749-110656527 (+)
FVB/NJ MGP_FVBNJ_G0019983
protein coding gene Chr12:109433009-109500144 (+)
LP/J MGP_LPJ_G0020072
protein coding gene Chr12:115412140-115453591 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020021
protein coding gene Chr12:126792111-126833202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020586
protein coding gene Chr12:113862929-113903323 (+)
PWK/PhJ MGP_PWKPhJ_G0019216
protein coding gene Chr12:105252006-105318235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019020
protein coding gene Chr12:108016675-108083314 (+)
WSB/EiJ MGP_WSBEiJ_G0019514
protein coding gene Chr12:114777364-114817565 (+)



Homology
more
  • Human Ortholog
    MTA1, metastasis associated 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MTA1, metastasis associated 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9112
    neXtProt AC: NX_Q13330
    UniProt: Q13330

  • Chr Location
    14q32.33; chr14:105419849-105470729 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3442
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MTA1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to ionizing radiation and increased retinal cell proliferation at E14.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116870 NCBI Gene Model | MGI Sequence Detail 38929 C57BL/6J ±  kb
    transcript NM_001364620 RefSeq | MGI Sequence Detail 2871 C57BL/6  
    polypeptide Q8K4B0 UniProt | EBI | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      Genomic 1
      cDNA 101
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Gene Ontology 17
      Phenotypes 20
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:247691 Marzook H, et al., Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells. Oncogene. 2017 Sep 14;36(37):5263-5273

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory