About   Help   FAQ
Mta1
Gene Detail
Symbol

Name
ID
Mta1
metastasis associated 1
MGI:2150037
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.57 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:113098278-113137206 bp, + strand
From VEGA annotation of GRCm38

  38929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MTA1
Gene Tree: Mta1

Human
homologs
MTA1, metastasis associated 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9112
neXtProt AC: NX_Q13330

Human Chr (Location): 14q32.3; chr14:105419849-105470729 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(39) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to ionizing radiation and increased retinal cell proliferation at E14.5.
 
Interactions
Mta1 interacts with 92 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process circadian regulation of gene expression, double-strand break repair, ...
Component cytoplasm, cytoskeleton, ...
Function chromatin binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (51)    Tissues (51)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mta1 ; ZFIN mta1    NEW 
Molecular
reagents
All nucleic(102) Genomic(1) cDNA(100) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017198 (Evidence)
Ensembl Gene Model ENSMUSG00000021144 (Evidence)
Entrez Gene 116870 (Evidence)
UniGene 212577
DFCI TC1575508, TC1589598, TC1597966, TC1639466
DoTS DT.99857603, DT.99857605, DT.60118730, DT.55137427
NIA Mouse Gene Index U291729, U014465
Consensus CDS Project CCDS36574.1
International Mouse Phenotyping Consortium Status Mta1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017198 VEGA Gene Model | MGI Sequence Detail 38929 C57BL/6J ±  kb
transcript OTTMUST00000041646 VEGA | MGI Sequence Detail 2826 Not Applicable 
polypeptide OTTMUSP00000018706 VEGA | MGI Sequence Detail 715 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(70) UniProt(12)
Polymorphisms
SNPs within 2kb(253 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR000949 ELM2 domain
InterPro IPR009057 Homeodomain-like
InterPro IPR017884 SANT domain
InterPro IPR001005 SANT/Myb domain
InterPro IPR000679 Zinc finger, GATA-type
Protein Ontology PR:000010707 metastasis-associated protein MTA1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:213644 Liu J, et al., The subcellular distribution and function of MTA1 in cancer differentiation. Oncotarget. 2014 Jul 15;5(13):5153-64
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory