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Spred2 Gene Detail
Summary
  • Symbol
    Spred2
  • Name
    sprouty-related EVH1 domain containing 2
  • Synonyms
    Spred-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150019
    NCBI Gene: 114716
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:19874442-19974026 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 12.79 cM, cytoband A3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    607 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150019
 protein coding gene Chr11:19874375-19974026 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018062
 protein coding gene Chr11:17392510-17501315 (+)
A/J MGP_AJ_G0018035
 protein coding gene Chr11:16818234-16924474 (+)
AKR/J MGP_AKRJ_G0017999
 protein coding gene Chr11:17426929-17534731 (+)
BALB/cJ MGP_BALBcJ_G0018003
 protein coding gene Chr11:16944878-17047441 (+)
C3H/HeJ MGP_C3HHeJ_G0017817
 protein coding gene Chr11:17315959-17424764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018455
 protein coding gene Chr11:18201225-18311107 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016113
 protein coding gene Chr11:15840811-15941995 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0017791
 protein coding gene Chr11:18952762-19089575 (+)
DBA/2J MGP_DBA2J_G0017901
 protein coding gene Chr11:16787006-16888175 (+)
FVB/NJ MGP_FVBNJ_G0017893
 protein coding gene Chr11:16518615-16620859 (+)
LP/J MGP_LPJ_G0017972
 protein coding gene Chr11:17576797-17682640 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017919
 protein coding gene Chr11:19440652-19547748 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018496
 protein coding gene Chr11:17503153-17608049 (+)
PWK/PhJ MGP_PWKPhJ_G0017158
 protein coding gene Chr11:16747211-16855180 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016956
 protein coding gene Chr11:17215363-17323011 (+)
WSB/EiJ MGP_WSBEiJ_G0017432
 protein coding gene Chr11:17173692-17276876 (+)



Homology
more
  • Human Ortholog
    SPRED2, sprouty related EVH1 domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRED2, sprouty related EVH1 domain containing 2
  • Synonyms
    NS14, Spred-2
  • Links
    NCBI Gene ID: 200734
    neXtProt AC: NX_Q7Z698
    UniProt: Q7Z698

  • Chr Location
    2p14; chr2:65307175-65432637 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Spred2 mouse models; 1 with human SPRED2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display increased hematopoietic cell formation in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1147
  • Tissues
    225
  • cDNA Data
    45
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114716 NCBI Gene Model | MGI Sequence Detail 99585 C57BL/6J ±  kb
    transcript NM_033523 RefSeq | MGI Sequence Detail 2872 C57BL/6  
    polypeptide Q924S7 UniProt | EBI | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 45
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144651
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 10
      Phenotypes 34
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345586 Wazin F, et al., Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth. Cells. 2024 Feb 6;13(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory