Spred2
Gene Detail

Symbol Name ID

Spred2 sprouty-related, EVH1 domain containing 2 MGI:2150019

Synonyms

Spred-2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

12.79 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:19924375-20024026 bp, + strand From VEGA annotation of GRCm38   99652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:24918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sprouty-related protein Spred
Gene Tree: Spred2

Human homologs

Human Homolog		SPRED2, sprouty-related, EVH1 domain containing 2
NCBI Gene ID		200734
neXtProt AC		NX_Q7Z698
Human Synonyms		Spred-2
Human Chr (Location)		2p14; chr2:65537985-65659656 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(288) : Targeted(1) Gene trapped(287)
 

Homozygous null mice are fertile and display increased hematopoietic cell formation in culture.

 
Human Diseases Modeled Using Mouse Spred2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	inactivation of MAPK activity, multicellular organismal development, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	protein binding, protein kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (34)    Tissues (23)    Images (5)
Theiler Stages: 19, 20, 22, 23, 24

Assay Type	Results
RNA in situ	27
Western blot	3
RT-PCR	4

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(41) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005219 (Evidence)
Ensembl Gene Model	ENSMUSG00000045671 (Evidence)
Entrez Gene	114716 (Evidence)
UniGene	266627
DFCI	TC1581055, TC1582783, TC1627813
DoTS	DT.522887, DT.55282773
NIA Mouse Gene Index	U012350
Consensus CDS Project	CCDS24454.1
International Mouse Knockout Project Status	Spred2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005219	VEGA Gene Model | MGI Sequence Detail	99652	C57BL/6J
transcript	OTTMUST00000011644	VEGA | MGI Sequence Detail	4449	Not Applicable
polypeptide	OTTMUSP00000005403	VEGA | MGI Sequence Detail	437	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(486 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023337	c-Kit-binding domain
InterPro	IPR000697	EVH1
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR007875	Sprouty
Protein Ontology	PR:000015569	sprouty-related, EVH1 domain-containing protein 2

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:187992 Wakabayashi H, et al., Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice. Clin Immunol. 2012 Sep;144(3):272-82
All references(51)

Other accession IDs

MGI:2144651