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Spred2 Gene Detail
Summary
  • Symbol
    Spred2
  • Name
    sprouty-related, EVH1 domain containing 2
  • Synonyms
    Spred-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150019
    NCBI Gene: 114716
  • Gene Overview
    MyGene.info: SPRED2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:19924375-20024026 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      99652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 12.79 cM, cytoband A3.2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPRED2, sprouty related EVH1 domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPRED2, sprouty related EVH1 domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Spred-2
  • Links
    NCBI Gene ID: 200734
    neXtProt AC: NX_Q7Z698
    UniProt: Q7Z698

  • Chr Location
    2p14; chr2:65307425-65432599 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Spred2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display increased hematopoietic cell formation in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005219 VEGA Gene Model | MGI Sequence Detail 99652 C57BL/6J ±  kb
    transcript OTTMUST00000011644 VEGA | MGI Sequence Detail 4449 Not Applicable  
    polypeptide OTTMUSP00000005403 VEGA | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      607 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144651
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264490 Yang X, et al., Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFalpha. Sci Rep. 2018 Jan 9;8(1):188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory