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Spred2
Gene Detail
Symbol

Name
ID
Spred2
sprouty-related, EVH1 domain containing 2
MGI:2150019
Synonyms
Spred-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
12.79 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:19924375-20024026 bp, + strand
From VEGA annotation of GRCm38

  99652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sprouty-related protein Spred
Gene Tree: Spred2

Human
homologs
Human Homolog SPRED2, sprouty-related, EVH1 domain containing 2
NCBI Gene ID 200734
neXtProt AC  NX_Q7Z698
Human Synonyms  Spred-2
Human Chr (Location)  2p14; chr2:65307442-65432637 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(288) : Gene trapped(287) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are fertile and display increased hematopoietic cell formation in culture.
 
Human Diseases Modeled Using Mouse Spred2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Spred2 interacts with 314 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process inactivation of MAPK activity, multicellular organismal development, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (428)    Tissues (219)    Images (110)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
In situ reporter (knock in) 368
Western blot 3
RT-PCR 4
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(42) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005219 (Evidence)
Ensembl Gene ModelENSMUSG00000045671 (Evidence)
Entrez Gene114716 (Evidence)
UniGene266627
DFCITC1582783, TC1627813, TC1581055
DoTSDT.55282773, DT.522887
NIA Mouse Gene IndexU012350
Consensus CDS ProjectCCDS24454.1
International Mouse Knockout Project StatusSpred2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005219 VEGA Gene Model | MGI Sequence Detail 99652 C57BL/6J ±  kb
transcript OTTMUST00000011644 VEGA | MGI Sequence Detail 4449 Not Applicable 
polypeptide OTTMUSP00000005403 VEGA | MGI Sequence Detail 437 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(611 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023337 c-Kit-binding domain
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR007875 Sprouty
Protein Ontology PR:000015569 sprouty-related, EVH1 domain-containing protein 2
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:187992 Wakabayashi H, et al., Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice. Clin Immunol. 2012 Sep;144(3):272-82
All references(51)
Disease annotation references (1)
Other
accession IDs
MGI:2144651

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory