About   Help   FAQ
Impa2 Gene Detail
Summary
  • Symbol
    Impa2
  • Name
    inositol monophosphatase 2
  • Synonyms
    2210415D20Rik, inositol (myo)-1(or 4)-monophosphatase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149728
    NCBI Gene: 114663
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:67422246-67454375 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 39.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149728
protein coding gene Chr18:67422246-67455542 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024521
protein coding gene Chr18:67564913-67594715 (+)
A/J MGP_AJ_G0024488
protein coding gene Chr18:64611087-64642455 (+)
AKR/J MGP_AKRJ_G0024458
protein coding gene Chr18:66512910-66542800 (+)
BALB/cJ MGP_BALBcJ_G0024487
protein coding gene Chr18:64783062-64813348 (+)
C3H/HeJ MGP_C3HHeJ_G0024255
protein coding gene Chr18:66668878-66699300 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024934
protein coding gene Chr18:69361955-69394204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022365
protein coding gene Chr18:63992331-64023490 (+)
CAST/EiJ MGP_CASTEiJ_G0023728
protein coding gene Chr18:66662282-66695567 (+)
CBA/J MGP_CBAJ_G0024225
protein coding gene Chr18:71739576-71772558 (+)
DBA/2J MGP_DBA2J_G0024355
protein coding gene Chr18:64268899-64298769 (+)
FVB/NJ MGP_FVBNJ_G0024321
protein coding gene Chr18:63640179-63670882 (+)
LP/J MGP_LPJ_G0024439
protein coding gene Chr18:67425000-67456712 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024350
protein coding gene Chr18:73022253-73052993 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024981
protein coding gene Chr18:66674828-66706403 (+)
PWK/PhJ MGP_PWKPhJ_G0023471
protein coding gene Chr18:64541645-64574602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023276
protein coding gene Chr18:66837041-66868339 (+)
WSB/EiJ MGP_WSBEiJ_G0023792
protein coding gene Chr18:66562575-66593635 (+)



Homology
more
  • Human Ortholog
    IMPA2, inositol monophosphatase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IMPA2, inositol monophosphatase 2
  • Links
    NCBI Gene ID: 3613
    neXtProt AC: NX_O14732
    UniProt: O14732

  • Chr Location
    18p11.21; chr18:11981025-12030877 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human IMPA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null gene trap mutation do not exhibit an overt mutant phenotype. Male mice homozygous for a knock-out alle exhibit increased prepulse inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114663 NCBI Gene Model | MGI Sequence Detail 32130 C57BL/6J ±  kb
    transcript NM_053261 RefSeq | MGI Sequence Detail 1737 C57BL/6  
    polypeptide Q91UZ5 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917400, MGI:2147214, MGI:2147360
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:250420 Ohnishi T, et al., Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. J Biol Chem. 2014 Apr 11;289(15):10785-96

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory