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Impa2 Gene Detail
Summary
  • Symbol
    Impa2
  • Name
    inositol (myo)-1(or 4)-monophosphatase 2
  • Synonyms
    2210415D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149728
    NCBI Gene: 114663
  • Gene Overview
    MyGene.info: IMPA2
Location & Maps
more
  • Sequence Map
    Chr18:67289223-67318841 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29619 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IMPA2, inositol monophosphatase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IMPA2, inositol monophosphatase 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 3613
    neXtProt AC: NX_O14732

  • Chr Location
    18p11.2; chr18:11981428-12030886 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null gene trap mutation do not exhibit an overt mutant phenotype. Male mice homozygous for a knock-out alle exhibit increased prepulse inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 114663 NCBI Gene Model | MGI Sequence Detail 29619 C57BL/6J ±  kb
transcript NM_053261 RefSeq | MGI Sequence Detail 1386 C57BL/6  
polypeptide Q91UZ5 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    174 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009018 inositol monophosphatase 2
  • EC
  • InterPro Domains
    IPR000760 Inositol monophosphatase
    IPR020550 Inositol monophosphatase, conserved site
    IPR020552 Inositol monophosphatase, Lithium-sensitive
    IPR020583 Inositol monophosphatase, metal-binding site
Molecular
Reagents
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  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1917400, MGI:2147214, MGI:2147360
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:193924 Ohnishi T, et al., Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013 Mar;124(5):685-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory