Foxp2
Gene Detail

Symbol Name ID

Foxp2 forkhead box P2 MGI:2148705

Synonyms

2810043D05Rik, D0Kist7

Feature Type

protein coding gene

Genetic Map

Chromosome 6

6.49 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:14901388-15441201 bp, + strand From VEGA annotation of GRCm38   539814 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:33482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxp2

Human homologs

Human Homolog		FOXP2, forkhead box P2
NCBI Gene ID		93986
neXtProt AC		NX_O15409
Human Synonyms		CAGH44, SPCH1, TNRC10
Human Chr (Location)		7q31; chr7:113726365-114333827 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXP2

Alleles and phenotypes

All alleles(11) : Targeted(8) Chemically induced(3)
 

Homozygous null mice display postnatal lethality, growth retardation, reduced vocalization, prolonged external granule cell layer presence, abnormal Purkinje and radial glial cells, delayed eye opening and ear emergence, negative geotaxis, impaired righting response, and hypoactivity.

 
Human Diseases Modeled Using Mouse Foxp2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	camera-type eye development, caudate nucleus development, ...
Component	cytoplasm, nucleus, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (95 records)
Data Summary: Results (777)    Tissues (211)    Images (105)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	730
Northern blot	10
Western blot	3
RT-PCR	24

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(23) Primer pair(4)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000022513 (Evidence)
Ensembl Gene Model	ENSMUSG00000029563 (Evidence)
Entrez Gene	114142 (Evidence)
DFCI	TC1582291, TC1588854, TC1594978, TC1595145, TC1596053, TC1597756, TC1623832, TC1685492
DoTS	DT.101265310, DT.101709698, DT.101735468, DT.40183146, DT.55160731, DT.87035227, DT.87040843, DT.91331243, DT.94192226
NIA Mouse Gene Index	U006558
Consensus CDS Project	CCDS19918.1
International Mouse Knockout Project Status	Foxp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022513	VEGA Gene Model | MGI Sequence Detail	539814	C57BL/6J
transcript	OTTMUST00000053923	VEGA | MGI Sequence Detail	2544	Not Applicable
polypeptide	OTTMUSP00000025672	VEGA | MGI Sequence Detail	739	Not Applicable

All sequences(123) RefSeq(4) UniProt(13)

Polymorphisms

SNPs(2538 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
InterPro	IPR015880	Zinc finger, C2H2-like
Protein Ontology	PR:000007644	forkhead box protein P2

References

(Earliest) J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
(Latest) J:191772 Favero CB, et al., Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain. J Comp Neurol. 2013 Feb 15;521(3):677-96
All references(143)

Other accession IDs

MGD-MRK-37478, MGI:108434, MGI:1919965, MGI:2141412