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Foxp2 Gene Detail
Summary
  • Symbol
    Foxp2
  • Name
    forkhead box P2
  • Synonyms
    2810043D05Rik, D0Kist7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148705
    NCBI Gene: 114142
  • Gene Overview
    MyGene.info: FOXP2
Location & Maps
more
  • Sequence Map
    Chr6:14901388-15441201 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      539814 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 6.49 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXP2, forkhead box P2
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FOXP2, forkhead box P2
    Orthology source: HGNC
  • Synonyms
    CAGH44, SPCH1, TNRC10
  • Links
    NCBI Gene ID: 93986
    neXtProt AC: NX_O15409

  • Chr Location
    7q31; chr7:114086310-114693772 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Foxp2 mouse models; 1 with human FOXP2 associations

Human Disease Mouse Models
       Speech-Language Disorder 1; SPCH1   OMIM: 602081 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 10 alleles in 9 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    3
  • Targeted
    8
  • Genomic Mutations
    1 involving Foxp2
  • Incidental Mutations
Homozygous null mice display postnatal lethality, growth retardation, reduced vocalization, prolonged external granule cell layer presence, abnormal Purkinje and radial glial cells, delayed eye opening and ear emergence, negative geotaxis, impaired righting response, and hypoactivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022513 VEGA Gene Model | MGI Sequence Detail 539814 C57BL/6J ±  kb
transcript OTTMUST00000053923 VEGA | MGI Sequence Detail 2544 Not Applicable  
polypeptide OTTMUSP00000025672 VEGA | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3047 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000007644 forkhead box protein P2
  • InterPro Domains
    IPR001766 Fork head domain
    IPR030456 Fork head domain conserved site 2
    IPR032354 FOXP, coiled-coil domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 48
    cDNA 44
    Primer pair 4

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-37478, MGI:108434, MGI:1919965, MGI:2141412
References
more
  • Summaries
    All 178
    Developmental Gene Expression 131
    Diseases 1
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
  • Latest
    J:231581 Cesario JM, et al., Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016 Mar;20(2):111-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory