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Foxp2 Gene Detail
Summary
  • Symbol
    Foxp2
  • Name
    forkhead box P2
  • Synonyms
    2810043D05Rik, D0Kist7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148705
    NCBI Gene: 114142
  • Gene Overview
    MyGene.info: FOXP2
  • Alliance
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:14901349-15441977 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 6.49 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3052 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148705
protein coding gene Chr6:14901349-15441977 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030464
protein coding gene Chr6:12029974-12603695 (+)
A/J MGP_AJ_G0030437
protein coding gene Chr6:11554440-12089258 (+)
AKR/J MGP_AKRJ_G0030364
protein coding gene Chr6:11994581-12542867 (+)
BALB/cJ MGP_BALBcJ_G0030446
protein coding gene Chr6:11595300-12161828 (+)
C3H/HeJ MGP_C3HHeJ_G0030160
protein coding gene Chr6:11866565-12429439 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030901
protein coding gene Chr6:12452022-13023622 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028112
protein coding gene Chr6:10651277-11171930 (+)
CAST/EiJ MGP_CASTEiJ_G0029562
protein coding gene Chr6:11723809-12293553 (+)
CBA/J MGP_CBAJ_G0030138
protein coding gene Chr6:12825639-13411784 (+)
DBA/2J MGP_DBA2J_G0030282
protein coding gene Chr6:11479532-12027329 (+)
FVB/NJ MGP_FVBNJ_G0030236
protein coding gene Chr6:11372577-11902994 (+)
LP/J MGP_LPJ_G0030369
protein coding gene Chr6:12110616-12666982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030272
protein coding gene Chr6:13720278-14436279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030931
protein coding gene Chr6:11859808-12420839 (+)
PWK/PhJ MGP_PWKPhJ_G0029276
protein coding gene Chr6:11158031-11697991 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029112
protein coding gene Chr6:11688518-12257064 (+)
WSB/EiJ MGP_WSBEiJ_G0029638
protein coding gene Chr6:11783286-12344367 (+)



Homology
more
  • Human Ortholog
    FOXP2, forkhead box P2
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FOXP2, forkhead box P2
    Orthology source: HGNC
  • Synonyms
    CAGH44, SPCH1, TNRC10
  • Links
    NCBI Gene ID: 93986
    neXtProt AC: NX_O15409
    UniProt: O15409

  • Chr Location
    7q31.1; chr7:114086310-114693772 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 10 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal lethality, growth retardation, reduced vocalization, prolonged external granule cell layer presence, abnormal Purkinje and radial glial cells, delayed eye opening and ear emergence, negative geotaxis, impaired righting response, and hypoactivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114142 NCBI Gene Model | MGI Sequence Detail 540629 C57BL/6J ±  kb
    transcript NM_053242 RefSeq | MGI Sequence Detail 6760 C57BL/6  
    polypeptide P58463 UniProt | EBI | MGI Sequence Detail 714 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR001766 Fork head domain
      IPR030456 Fork head domain conserved site 2
      IPR032354 FOXP, coiled-coil domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
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    • All nucleic 61
      cDNA 51
      Primer pair 9
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-37478, MGI:108434, MGI:1919965, MGI:2141412
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 170
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
    • Latest
      J:265269 D D, et al., RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 2018 Jun 15;38(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory