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Foxp2
Gene Detail
Symbol

Name
ID
Foxp2
forkhead box P2
MGI:2148705
Synonyms
2810043D05Rik, D0Kist7
Feature Type
protein coding gene
Genetic Map
Chromosome 6
6.49 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:14901388-15441201 bp, + strand
From VEGA annotation of GRCm38

  539814 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134404  Vertebrate Homology Class
1 mouse; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Foxp2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display postnatal lethality, growth retardation, reduced vocalization, prolonged external granule cell layer presence, abnormal Purkinje and radial glial cells, delayed eye opening and ear emergence, negative geotaxis, impaired righting response, and hypoactivity.
 
Human Diseases Modeled Using Mouse Foxp2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Foxp2 interacts with 523 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process camera-type eye development, cerebellum development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (114 records)
Data Summary: Results (933)    Tissues (240)    Images (230)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 159
RNA in situ 744
Northern blot 10
Western blot 3
RT-PCR 17
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(44) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000022513 (Evidence)
Ensembl Gene ModelENSMUSG00000029563 (Evidence)
Entrez Gene114142 (Evidence)
UniGene332919
DFCITC1623832, TC1685492, TC1596053, TC1597756, TC1582291, TC1595145, TC1594978, TC1588854
DoTSDT.101265310, DT.91331243, DT.87040843, DT.87035227, DT.55160731, DT.101735468, DT.40183146, DT.94192226, DT.101709698
NIA Mouse Gene IndexU006558
Consensus CDS ProjectCCDS19918.1, CCDS71726.1
International Mouse Knockout Project StatusFoxp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022513 VEGA Gene Model | MGI Sequence Detail 539814 C57BL/6J ±  kb
transcript OTTMUST00000053923 VEGA | MGI Sequence Detail 2544 Not Applicable 
polypeptide OTTMUSP00000025672 VEGA | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(8) UniProt(25)
Polymorphisms
SNPs within 2kb(3049 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000007644 forkhead box protein P2
References
(Earliest) J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
(Latest) J:212008 Fujita-Jimbo E, et al., Specific expression of FOXP2 in cerebellum improves ultrasonic vocalization in heterozygous but not in homozygous Foxp2 (R552H) knock-in pups. Neurosci Lett. 2014 Apr 30;566:162-6
All references(163)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37478, MGI:108434, MGI:1919965, MGI:2141412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory