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Taar1
Gene Detail
 Symbol
Name
ID
Taar1
trace amine-associated receptor 1
MGI:2148258
Synonyms Tar1, Trar1
Feature Type protein coding gene
Genetic Map
Chromosome 10
11.39 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:23920406-23921404 bp, + strand
From NCBI annotation of GRCm38

  999 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: trace amine-associated receptor
Gene Tree: Taar1

Human
homologs
Human Homolog TAAR1, trace amine associated receptor 1
NCBI Gene ID 134864
neXtProt AC  NX_Q96RJ0
Human Synonyms  TA1, TAR1, TRAR1
Human Chr (Location)  6q23.2; chr6:132644984-132646003 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity.
 
Human Diseases Modeled Using Mouse Taar1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Taar1 interacts with 25 markers (Mir214, Mir384, Mir495, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process adenylate cyclase-activating dopamine receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled amine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 28
Assay TypeResults
RT-PCR 2
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000056379 (Evidence)
Entrez Gene111174 (Evidence)
UniGene377141
DoTSDT.101263754
Consensus CDS ProjectCCDS23735.1
International Mouse Knockout Project StatusTaar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 111174 NCBI Gene Model | MGI Sequence Detail 999 C57BL/6J ±  kb
transcript NM_053205 RefSeq | MGI Sequence Detail 999 129X1/SvJ 
polypeptide Q923Y8 UniProt | EBI | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(11) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR009132 Trace amine receptor
InterPro IPR009133 Trace amine receptor 1
Protein Ontology PR:000001711 trace amine-associated receptor 1
Graphical View of Protein Domain Structure
References (Earliest) J:70672 Borowsky B, et al., From the Cover: Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71
(Latest) J:197678 Dewan A, et al., Non-redundant coding of aversive odours in the main olfactory pathway. Nature. 2013 May 23;497(7450):486-9
All references(34)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory