Taar1
Gene Detail

Symbol Name ID

Taar1 trace amine-associated receptor 1 MGI:2148258

Synonyms

Tar1, Trar1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

11.39 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:23920406-23921404 bp, + strand From NCBI annotation of GRCm38   999 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:24938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: trace amine-associated receptor
Gene Tree: Taar1

Human homologs

Human Homolog		TAAR1, trace amine associated receptor 1
NCBI Gene ID		134864
neXtProt AC		NX_Q96RJ0
Human Synonyms		RP11-295F4.9, TA1, TAR1, TRAR1
Human Chr (Location)		6q23.2; chr6:132966123-132967142 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity.

 
Human Diseases Modeled Using Mouse Taar1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	adenylate cyclase-activating dopamine receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled amine receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 28

Assay Type	Results
RT-PCR	2

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000056379 (Evidence)
Entrez Gene	111174 (Evidence)
UniGene	377141
DoTS	DT.101263754
Consensus CDS Project	CCDS23735.1
International Mouse Knockout Project Status	Taar1

Sequences

Length	Strain/Species
genomic	111174	NCBI Gene Model | MGI Sequence Detail	999	C57BL/6J
transcript	NM_053205	RefSeq | MGI Sequence Detail	999	129X1/SvJ
polypeptide	Q923Y8	UniProt | EBI | MGI Sequence Detail	332	Not Applicable

All sequences(11) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR009132	Trace amine receptor
InterPro	IPR009133	Trace amine receptor 1
Protein Ontology	PR:000001711	trace amine-associated receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:70672 Borowsky B, et al., From the Cover: Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71
(Latest) J:178061 Di Cara B, et al., Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA). J Neurosci. 2011 Nov 23;31(47):16928-16940
All references(31)