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Ift140
Gene Detail
Symbol

Name
ID
Ift140
intraflagellar transport 140
MGI:2146906
Synonyms
mKIAA0590, Tce5, Wdtc2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:25016091-25099495 bp, + strand
From VEGA annotation of GRCm38

  83405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IFT140
Gene Tree: Ift140

Human
homologs
IFT140, intraflagellar transport 140
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9742
neXtProt AC: NX_Q96RY7

Human Synonyms: c305C8.4, c380F5.1, gs114, MZSDS, SRTD9, WDTC2

Human Chr (Location): 16p13.3; chr16:1510427-1612108 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IFT140

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(5) Radiation induced(2) Targeted(4)
Genomic Mutations involving Ift140 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a reporter knock-out allele die at mid-gestation. Mice homozygous for an ENU-induced mutation exhibit cardiovascular defects and situs abnormalities.
 
Human Diseases Modeled in Mice Using Ift140 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(16)
Interactions
Ift140 interacts with 103 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cilium assembly, cilium morphogenesis, ...
Component axoneme, cell, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 10
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ift140    NEW 
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024886 (Evidence)
Ensembl Gene Model ENSMUSG00000024169 (Evidence)
Entrez Gene 106633 (Evidence)
DFCI TC1596010, TC1577776, TC1634758, TC1776678
DoTS DT.101212581, DT.101364610, DT.40156038, DT.97386960, DT.40157842, DT.485881
NIA Mouse Gene Index U305743, U017662
Consensus CDS Project CCDS28505.1
International Mouse Phenotyping Consortium Status Ift140
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024886 VEGA Gene Model | MGI Sequence Detail 83405 C57BL/6J ±  kb
transcript OTTMUST00000061294 VEGA | MGI Sequence Detail 5489 Not Applicable 
polypeptide OTTMUSP00000030035 VEGA | MGI Sequence Detail 1464 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(19) UniProt(9)
Polymorphisms
SNPs within 2kb(854 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008932 intraflagellar transport protein 140
References
(Earliest) J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
(Latest) J:217609 Goggolidou P, et al., ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014 Oct;141(20):3966-77
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:1930191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory