About   Help   FAQ
Ift140
Gene Detail
Symbol

Name
ID
Ift140
intraflagellar transport 140
MGI:2146906
Synonyms
mKIAA0590, Tce5, Wdtc2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:25016091-25099495 bp, + strand
From VEGA annotation of GRCm38

  83405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ift140

Human
homologs
Human Homolog IFT140, intraflagellar transport 140
NCBI Gene ID 9742
neXtProt AC  NX_Q96RY7
Human Synonyms  c305C8.4, c380F5.1, gs114, MZSDS, SRTD9, WDTC2
Human Chr (Location)  16p13.3; chr16:1510427-1612108 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IFT140
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(5) Radiation induced(2) Targeted(4)
Genomic Mutations involving Ift140 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter knock-out allele die at mid-gestation. Mice homozygous for an ENU-induced mutation exhibit cardiovascular defects and situs abnormalities.
 
Human Diseases Modeled Using Mouse Ift140 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(15)
Interactions
Ift140 interacts with 103 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cilium assembly, cilium morphogenesis, ...
Component axoneme, cell, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024886 (Evidence)
Ensembl Gene ModelENSMUSG00000024169 (Evidence)
Entrez Gene106633 (Evidence)
DFCITC1577776, TC1596010, TC1634758, TC1776678
DoTSDT.101212581, DT.101364610, DT.40156038, DT.40157842, DT.485881, DT.97386960
NIA Mouse Gene IndexU017662, U305743
Consensus CDS ProjectCCDS28505.1
International Mouse Knockout Project StatusIft140
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024886 VEGA Gene Model | MGI Sequence Detail 83405 C57BL/6J ±  kb
transcript OTTMUST00000061294 VEGA | MGI Sequence Detail 5489 Not Applicable 
polypeptide OTTMUSP00000030035 VEGA | MGI Sequence Detail 1464 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(854 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008932 intraflagellar transport protein 140
References
(Earliest) J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
(Latest) J:206902 Schmidts M, et al., Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease. Hum Mutat. 2013 May;34(5):714-24
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:1930191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory