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Tfb1m
Gene Detail
Symbol

Name
ID
Tfb1m
transcription factor B1, mitochondrial
MGI:2146851
Synonyms
MGC:41387
Feature Type
protein coding gene
Genetic Map
Chromosome 17
2.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:3519263-3557713 bp, - strand
From Ensembl annotation of GRCm38

  38451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9343  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dimethyladenosine transferase (rRNA adenosine dimethyltransferase)
Gene Tree: Tfb1m

Human
homologs
Human Homolog TFB1M, transcription factor B1, mitochondrial
NCBI Gene ID 51106
neXtProt AC  NX_Q8WVM0
Human Synonyms  CGI75, mtTFB, mtTFB1
Human Chr (Location)  6q25.1-q25.3; chr6:155253361-155314497 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with developmental defects and reduced mitochondrial function at E8.5.
 
Interactions
Tfb1m interacts with 71 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(25) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000036983 (Evidence)
Entrez Gene224481 (Evidence)
UniGene226554
DFCITC1651183
NIA Mouse Gene IndexU017453
EC2.1.1.-
PDB4GC5, 4GC9
Consensus CDS ProjectCCDS28363.1
International Mouse Knockout Project StatusTfb1m
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036983 Ensembl Gene Model | MGI Sequence Detail 38451 C57BL/6J ±  kb
transcript ENSMUST00000041003 Ensembl | MGI Sequence Detail 1327 Not Applicable 
polypeptide ENSMUSP00000035291 Ensembl | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(5) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011530 Ribosomal RNA adenine dimethylase
InterPro IPR001737 Ribosomal RNA adenine methylase transferase
InterPro IPR020596 Ribosomal RNA adenine methylase transferase, conserved site
InterPro IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
InterPro IPR023165 rRNA adenine dimethylase-like
Protein Ontology PR:000016267 dimethyladenosine transferase 1, mitochondrial
References
(Earliest) J:81452 Rantanen A, et al., Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. Mamm Genome. 2003 Jan;14(1):1-6
(Latest) J:214733 Sharoyko VV, et al., Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. Hum Mol Genet. 2014 Nov 1;23(21):5733-49
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory