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Tfb1m Gene Detail
Summary
  • Symbol
    Tfb1m
  • Name
    transcription factor B1, mitochondrial
  • Synonyms
    MGC:41387
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146851
    NCBI Gene: 224481
  • Gene Overview
    MyGene.info: TFB1M
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:3519256-3557777 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 2.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    404 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146851
protein coding gene Chr17:3519256-3557777 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023099
protein coding gene Chr17:494255-533874 (-)
A/J MGP_AJ_G0023070
protein coding gene Chr17:601267-641489 (-)
AKR/J MGP_AKRJ_G0023036
protein coding gene Chr17:529304-572736 (-)
BALB/cJ MGP_BALBcJ_G0023072
protein coding gene Chr17:514331-560156 (-)
C3H/HeJ MGP_C3HHeJ_G0022831
protein coding gene Chr17:606618-650001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023518
protein coding gene Chr17:641842-681151 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021018
protein coding gene Chr17:427529-466288 (-)
CAST/EiJ MGP_CASTEiJ_G0022350
protein coding gene Chr17:590887-632572 (-)
CBA/J MGP_CBAJ_G0022799
protein coding gene Chr17:612779-655845 (-)
DBA/2J MGP_DBA2J_G0022934
protein coding gene Chr17:455518-494437 (-)
FVB/NJ MGP_FVBNJ_G0022908
protein coding gene Chr17:480233-519037 (-)
LP/J MGP_LPJ_G0023003
protein coding gene Chr17:640144-680033 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022929
protein coding gene Chr17:569033-608379 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023535
protein coding gene Chr17:519118-558582 (-)
PWK/PhJ MGP_PWKPhJ_G0022095
protein coding gene Chr17:496154-533785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021923
protein coding gene Chr17:471704-513692 (-)
WSB/EiJ MGP_WSBEiJ_G0022401
protein coding gene Chr17:525341-566412 (-)



Homology
more
  • Human Ortholog
    TFB1M, transcription factor B1, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TFB1M, transcription factor B1, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI75, CGI-75, mtTFB, mtTFB1
  • Links
    NCBI Gene ID: 51106
    neXtProt AC: NX_Q8WVM0
    UniProt: Q8WVM0

  • Chr Location
    6q25.3; chr6:155229990-155314497 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with developmental defects and reduced mitochondrial function at E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224481 NCBI Gene Model | MGI Sequence Detail 38522 C57BL/6J ±  kb
    transcript NM_146074 RefSeq | MGI Sequence Detail 1410 C57BL/6  
    polypeptide Q8JZM0 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016267 dimethyladenosine transferase 1, mitochondrial
    • PDB
    • EC
    • InterPro Domains
      IPR011530 Ribosomal RNA adenine dimethylase
      IPR020596 Ribosomal RNA adenine methylase transferase, conserved site
      IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
      IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm
      IPR023165 rRNA adenine dimethylase-like
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:81452 Rantanen A, et al., Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. Mamm Genome. 2003 Jan;14(1):1-6
    • Latest
      J:235368 Gomez-Del Arco P, et al., The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10;23(5):881-92

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory