Tfb1m Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tfb1m
transcription factor B1, mitochondrial
MGI:2146851

17 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tfb1m^tm1.1Lrsn/Tfb1m^tm1.1Lrsn Tg(Ckmm-cre)5Khn/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL	abnormal myocardial fiber morphology	J:148166
	abnormal myocardial fiber physiology	J:148166
	increased heart weight	J:148166
	premature death	J:148166
Tfb1m^tm1.2Lrsn/Tfb1m^tm1.2Lrsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL	abnormal respiratory electron transport chain	J:148166
	absent heart	J:148166
	absent optic disk	J:148166
	decreased embryo size	J:148166
	open neural tube	J:148166
	prenatal lethality, complete penetrance	J:148166
Tg(CAG-Tfb1m)AGsha/0 B6J.Cg-Tg(CAG-Tfb1m)AGsha	abnormal auditory brainstem response waveform shape	J:228068
	abnormal cochlear outer hair cell electromotility	J:228068
	decreased endocochlear potential	J:228068
	impaired hearing	J:228068
	increased or absent threshold for auditory brainstem response	J:228068
Tg(CAG-Tfb1m)AGsha/? involves: C57BL/6J * SJL/J	abnormal vestibulocochlear ganglion morphology	J:181548
	impaired hearing	J:181548
	increased or absent threshold for auditory brainstem response	J:181548
	increased susceptibility to age-related hearing loss	J:181548

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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