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Cblb Gene Detail
Summary
  • Symbol
    Cblb
  • Name
    Casitas B-lineage lymphoma b
  • Synonyms
    Cbl-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146430
    NCBI Gene: 208650
  • Gene Overview
    MyGene.info: CBLB
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:52031230-52208047 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 32.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146430
protein coding gene Chr16:52031225-52208048 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022877
protein coding gene Chr16:50966071-51153081 (+)
A/J MGP_AJ_G0022844
protein coding gene Chr16:48745918-48927412 (+)
AKR/J MGP_AKRJ_G0022816
protein coding gene Chr16:50381919-50563714 (+)
BALB/cJ MGP_BALBcJ_G0022844
protein coding gene Chr16:48846542-49025822 (+)
C3H/HeJ MGP_C3HHeJ_G0022607
protein coding gene Chr16:50462695-50649599 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023292
protein coding gene Chr16:52330774-52518423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020804
protein coding gene Chr16:48704423-48878356 (+)
CAST/EiJ MGP_CASTEiJ_G0022133
protein coding gene Chr16:50824971-51018981 (+)
CBA/J MGP_CBAJ_G0022580
protein coding gene Chr16:54392968-54603906 (+)
DBA/2J MGP_DBA2J_G0022712
protein coding gene Chr16:48496854-48676365 (+)
FVB/NJ MGP_FVBNJ_G0022687
protein coding gene Chr16:48332232-48509518 (+)
LP/J MGP_LPJ_G0022779
protein coding gene Chr16:50771101-50955092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022705
protein coding gene Chr16:54194025-54392800 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023307
protein coding gene Chr16:50459497-50644128 (+)
PWK/PhJ MGP_PWKPhJ_G0021873
protein coding gene Chr16:48822570-49000679 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021703
protein coding gene Chr16:50263489-50450725 (+)
WSB/EiJ MGP_WSBEiJ_G0022178
protein coding gene Chr16:50427195-50613105 (+)



Homology
more
  • Human Ortholog
    CBLB, Cbl proto-oncogene B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CBLB, Cbl proto-oncogene B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Cbl-b, Nbla00127, RNF56
  • Links
    NCBI Gene ID: 868
    neXtProt AC: NX_Q13191
    UniProt: Q13191

  • Chr Location
    3q13.11; chr3:105655461-105869552 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 5 genetic backgrounds
    16 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit elevated IL2 production by T cells, develop spontaneous autoimmunity, and are highly susceptible to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 208650 NCBI Gene Model | MGI Sequence Detail 176818 C57BL/6J ±  kb
transcript NM_001033238 RefSeq | MGI Sequence Detail 6323 C57BL/6  
polypeptide Q3TTA7 UniProt | EBI | MGI Sequence Detail 982 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146506
References
more
  • Summaries
    All 119
    Developmental Gene Expression 1
    Gene Ontology 14
    Phenotypes 74
  • Earliest
    J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
  • Latest
    J:265219 Nanjappa SG, et al., CBLB Constrains Inactivated Vaccine-Induced CD8(+) T Cell Responses and Immunity against Lethal Fungal Pneumonia. J Immunol. 2018 Sep 15;201(6):1717-1726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory