Trib2 MGI Mouse Gene Detail - MGI:2145021

Trib2 Gene Detail

Symbol

Trib2
Name

tribbles pseudokinase 2
Synonyms

TRB2

Feature Type

protein coding gene
IDs

MGI:2145021
NCBI Gene: 217410
Gene Overview

MyGene.info: TRIB2
Alliance

gene page

Sequence Map

Chr12:15791727-15816877 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

25151 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 7.25 cM
Mapping Data

2 experiments

Human Ortholog

TRIB2, tribbles pseudokinase 2

Vertebrate Orthologs

8

Human Ortholog

TRIB2, tribbles pseudokinase 2
Orthology source: HomoloGene, HGNC
Synonyms

C5FW, GS3955, TRB2
Links

HGNC:30809

NCBI Gene ID: 28951

neXtProt AC: NX_Q92519

UniProt: Q92519
Chr Location

2p24.3; chr2:12716872-12742734 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41445
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: TRIB2
Gene Tree

Trib2

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
24 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

2
Targeted

7
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.

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All GO Annotations

18
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

160
Tissues

149
cDNA Data

101
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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Trib2 interacts with 306 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

36
RefSeq

6
UniProt

3
CCDS

CCDS25821.1
UniGene

491136

			Length	Strain/Species	Flank
genomic	OTTMUSG00000027552	VEGA Gene Model \| MGI Sequence Detail	25151	C57BL/6J	± kb
transcript	OTTMUST00000068228	VEGA \| MGI Sequence Detail	4198	Not Applicable
polypeptide	OTTMUSP00000034443	VEGA \| MGI Sequence Detail	343	Not Applicable

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SNPs within 2kb

133 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000016639 tribbles homolog 2

(term hierarchy)
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40

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All nucleic 104

cDNA 101

Primer pair 2

Other 1

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 7

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013;
Latest

J:243595 Grochowska KM, et al., Posttranslational modification impact on the mechanism by which amyloid-beta induces synaptic dysfunction. EMBO Rep. 2017 Jun;18(6):962-981

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/10/2017 MGI 6.10