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Trib2
Gene Detail
 Symbol
Name
ID
Trib2
tribbles homolog 2 (Drosophila)
MGI:2145021
Synonyms TRB2
Feature Type protein coding gene
Genetic Map
Chromosome 12
7.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:15791727-15816877 bp, - strand
From VEGA annotation of GRCm38

  25151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41445  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trib2

Human
homologs
Human Homolog TRIB2, tribbles pseudokinase 2
NCBI Gene ID 28951
neXtProt AC  NX_Q92519
Human Synonyms  C5FW, GS3955, TRB2
Human Chr (Location)  2p24.3; chr2:12716872-12742734 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
 
Human Diseases Modeled Using Mouse Trib2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Trib2 interacts with 307 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process negative regulation of fat cell differentiation, negative regulation of interleukin-10 biosynthetic process, ...
Component cytoplasm, cytoskeleton
Function ATP binding, protein kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (160)    Tissues (149)    Images (18)
Theiler Stages: 19, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 136
In situ reporter (knock in) 20
RT-PCR 4
cDNA source data(101)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) cDNA(101) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027552 (Evidence)
Ensembl Gene ModelENSMUSG00000020601 (Evidence)
Entrez Gene217410 (Evidence)
UniGene491136
DFCITC1572267, TC1583317, TC1682957
DoTSDT.91568544
NIA Mouse Gene IndexU033826
Consensus CDS ProjectCCDS25821.1
International Mouse Knockout Project StatusTrib2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027552 VEGA Gene Model | MGI Sequence Detail 25151 C57BL/6J ±  kb
transcript OTTMUST00000068228 VEGA | MGI Sequence Detail 4198 Not Applicable 
polypeptide OTTMUSP00000034443 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40
Protein Ontology PR:000016639 tribbles homolog 2
References (Earliest) J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013;
(Latest) J:210161 Rishi L, et al., Regulation of Trib2 by an E2F1-C/EBPalpha feedback loop in AML cell proliferation. Blood. 2014 Apr 10;123(15):2389-400
All references(46)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory