Trib2
Gene Detail

Symbol

Name
ID

Trib2
tribbles homolog 2 (Drosophila)
MGI:2145021

Synonyms

TRB2

Feature Type

protein coding gene

Genetic Map

Chromosome 12
7.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:15791727-15816877 bp, - strand From VEGA annotation of GRCm38   25151 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41445  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trib2

Human
homologs

Human Homolog		TRIB2, tribbles pseudokinase 2
NCBI Gene ID		28951
neXtProt AC		NX_Q92519
Human Synonyms		C5FW, GS3955, TRB2
Human Chr (Location)		2p24.3; chr2:12716872-12742734 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Gene trapped(2) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.

 
Human Diseases Modeled in Mice Using Trib2 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Trib2 interacts with 307 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (16 annotations)

Process	negative regulation of fat cell differentiation, negative regulation of interleukin-10 biosynthetic process, ...
Component	cytoplasm, cytoskeleton
Function	ATP binding, protein kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (160)    Tissues (149)    Images (18)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	136
In situ reporter (knock in)	20
RT-PCR	4

cDNA source data(101)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(104) cDNA(101) Primer pair(2) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000027552 (Evidence)
Ensembl Gene Model	ENSMUSG00000020601 (Evidence)
Entrez Gene	217410 (Evidence)
UniGene	491136
DFCI	TC1682957, TC1583317, TC1572267
DoTS	DT.91568544
NIA Mouse Gene Index	U033826
Consensus CDS Project	CCDS25821.1
International Mouse Knockout Project Status	Trib2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027552	VEGA Gene Model | MGI Sequence Detail	25151	C57BL/6J
transcript	OTTMUST00000068228	VEGA | MGI Sequence Detail	4198	Not Applicable
polypeptide	OTTMUSP00000034443	VEGA | MGI Sequence Detail	343	Not Applicable

All sequences(35) RefSeq(6) UniProt(1)

Polymorphisms

SNPs within 2kb(136 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR024104	Pseudokinase tribbles family/serine-threonine-protein kinase 40
Protein Ontology	PR:000016639	tribbles homolog 2

References

(Earliest) J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013;
(Latest) J:215219 Ord T, et al., Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet. PLoS One. 2014;9(4):e94691
All references(47)
Disease annotation references (1)