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Trib2
Gene Detail
Symbol

Name
ID
Trib2
tribbles homolog 2 (Drosophila)
MGI:2145021
Synonyms
TRB2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
7.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:15791727-15816877 bp, - strand
From VEGA annotation of GRCm38

  25151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41445  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRIB2
Gene Tree: Trib2

Human
homologs
TRIB2, tribbles pseudokinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 28951
neXtProt AC: NX_Q92519

Human Synonyms: C5FW, GS3955, TRB2

Human Chr (Location): 2p24.3; chr2:12716872-12742734 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
 
Human Diseases Modeled in Mice Using Trib2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trib2 interacts with 306 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (160)    Tissues (149)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
In situ reporter (knock in) 20
RT-PCR 4
cDNA source data(101)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase trib2    NEW 
Molecular
reagents
All nucleic(104) cDNA(101) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027552 (Evidence)
Ensembl Gene Model ENSMUSG00000020601 (Evidence)
Entrez Gene 217410 (Evidence)
UniGene 491136
DFCI TC1572267, TC1682957, TC1583317
DoTS DT.91568544
NIA Mouse Gene Index U033826
Consensus CDS Project CCDS25821.1
International Mouse Phenotyping Consortium Status Trib2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027552 VEGA Gene Model | MGI Sequence Detail 25151 C57BL/6J ±  kb
transcript OTTMUST00000068228 VEGA | MGI Sequence Detail 4198 Not Applicable 
polypeptide OTTMUSP00000034443 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40
Protein Ontology PR:000016639 tribbles homolog 2
References
(Earliest) J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013;
(Latest) J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All references(47)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory