Trib2
Gene Detail

Symbol Name ID

Trib2 tribbles homolog 2 (Drosophila) MGI:2145021

Synonyms

TRB2

Feature Type

protein coding gene

Genetic Map

Chromosome 12

7.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:15791727-15816877 bp, - strand From VEGA annotation of GRCm38   25151 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trib2 ± 2 cM)

Gene Tree: Trib2

Human ortholog

TRIB2 tribbles homolog 2 (Drosophila) NCBI Gene ID 28951
Human Synonyms: C5FW, GS3955, TRB2
Human Chr2:12856998-12882860 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(2) Transgenic(1)
 

Mice homozygous for a null allele exhibit normal development and kidney morphology and physiology. In another null allele, homozygous mice exhibit increased mean percentage of CD8 cells and decreased mean percentage of B cells in the peripheral blood, and decreased exploratory activity in open field

 
Human Diseases Modeled Using Mouse Trib2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	negative regulation of fat cell differentiation, negative regulation of interleukin-10 biosynthetic process, ...
Component	cytoplasm, cytoskeleton
Function	ATP binding, protein kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (148)    Tissues (137)    Images (17)
Theiler Stages: 19, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	124
In situ reporter (knock in)	20
RT-PCR	4

cDNA source data(98)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(101) cDNA(98) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027552 (Evidence)
Ensembl Gene Model	ENSMUSG00000020601 (Evidence)
Entrez Gene	217410 (Evidence)
UniGene	485040
DFCI	TC1572267, TC1583317, TC1682957
DoTS	DT.91568544
NIA Mouse Gene Index	U033826
Consensus CDS Project	CCDS25821.1
International Mouse Knockout Project Status	Trib2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027552	VEGA Gene Model | MGI Sequence Detail	25151	C57BL/6J
transcript	OTTMUST00000068228	VEGA | MGI Sequence Detail	4198	Not Applicable
polypeptide	OTTMUSP00000034443	VEGA | MGI Sequence Detail	343	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR024104	Pseudokinase tribbles family/serine-threonine-protein kinase 40
Protein Ontology	PR:000016639	tribbles 2

References

(Earliest) J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2012;
(Latest) J:186639 Nussbaum JM, et al., Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta. Nature. 2012 May 31;485(7400):651-5
All references(42)