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Usp22
Gene Detail
Symbol

Name
ID
Usp22
ubiquitin specific peptidase 22
MGI:2144157
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:61151785-61175055 bp, - strand
From VEGA annotation of GRCm38

  23271 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: USP22
Gene Tree: Usp22

Human
homologs
USP22, ubiquitin specific peptidase 22
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23326
neXtProt AC: NX_Q9UPT9

Human Synonyms: USP3L

Human Chr (Location): 17p11.2; chr17:20999593-21043409 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Genomic Mutations involving Usp22 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality around E10.5, decreased embryo size, embryonic growth retardation and increased apoptosis in mouse embryonic fibroblast.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Usp22 interacts with 252 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cell cycle, chromatin modification, ...
Component nucleus, SAGA complex, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (204)    Tissues (85)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 173
Northern blot 31
cDNA source data(179)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase usp22    NEW 
Molecular
reagents
All nucleic(183) cDNA(181) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005825 (Evidence)
Ensembl Gene Model ENSMUSG00000042506 (Evidence)
Entrez Gene 216825 (Evidence)
UniGene 30602
DFCI TC1597100, TC1574787
DoTS DT.97409353, DT.484881
NIA Mouse Gene Index U032879
EC 3.4.19.12
Consensus CDS Project CCDS24807.1
International Mouse Phenotyping Consortium Status Usp22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005825 VEGA Gene Model | MGI Sequence Detail 23271 C57BL/6J ±  kb
transcript OTTMUST00000012927 VEGA | MGI Sequence Detail 4434 Not Applicable 
polypeptide OTTMUSP00000006014 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001607 Zinc finger, UBP-type
Protein Ontology PR:000017161 ubiquitin carboxyl-terminal hydrolase 22
References
(Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:188021 Lin Z, et al., USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory