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Usp22 Gene Detail
Summary
  • Symbol
    Usp22
  • Name
    ubiquitin specific peptidase 22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144157
    NCBI Gene: 216825
  • Gene Overview
    MyGene.info: USP22
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61151785-61175055 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144157
protein coding gene Chr11:61151781-61175059 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018433
protein coding gene Chr11:61099492-61122756 (-)
A/J MGP_AJ_G0018402
protein coding gene Chr11:58843626-58866896 (-)
AKR/J MGP_AKRJ_G0018372
protein coding gene Chr11:60683919-60707183 (-)
BALB/cJ MGP_BALBcJ_G0018373
protein coding gene Chr11:59146337-59169602 (-)
C3H/HeJ MGP_C3HHeJ_G0018186
protein coding gene Chr11:60660288-60683558 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018825
protein coding gene Chr11:63035709-63060899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016471
protein coding gene Chr11:55981237-56004385 (-)
CAST/EiJ MGP_CASTEiJ_G0017743
protein coding gene Chr11:60759619-60790425 (-)
CBA/J MGP_CBAJ_G0018160
protein coding gene Chr11:65775590-65798860 (-)
DBA/2J MGP_DBA2J_G0018269
protein coding gene Chr11:58425144-58448410 (-)
FVB/NJ MGP_FVBNJ_G0018260
protein coding gene Chr11:58101387-58124684 (-)
LP/J MGP_LPJ_G0018342
protein coding gene Chr11:61676631-61699900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018284
protein coding gene Chr11:66802709-66825987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018866
protein coding gene Chr11:60812269-60835539 (-)
PWK/PhJ MGP_PWKPhJ_G0017516
protein coding gene Chr11:59016752-59045898 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017306
protein coding gene Chr11:60625781-60652914 (-)
WSB/EiJ MGP_WSBEiJ_G0017795
protein coding gene Chr11:60424075-60447373 (-)



Homology
more
  • Human Ortholog
    USP22, ubiquitin specific peptidase 22
  • Vertebrate Orthologs
    9
  • Human Ortholog
    USP22, ubiquitin specific peptidase 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    USP3L
  • Links
    NCBI Gene ID: 23326
    neXtProt AC: NX_Q9UPT9
    UniProt: Q9UPT9

  • Chr Location
    17p11.2; chr17:20999593-21043409 (-)  GRCh38.p7

Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality, embryonic growth retardation, and increased apoptosis in mouse embryonic fibroblasts. Homozygotes for a hypomorphic allele are viable but show postnatal growth retardation, and impaired cell differentiation in the small intestine and brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042506 Ensembl Gene Model | MGI Sequence Detail 23271 C57BL/6J ±  kb
    transcript ENSMUST00000041683 Ensembl | MGI Sequence Detail 4434 Not Applicable  
    polypeptide ENSMUSP00000041263 Ensembl | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 184
      cDNA 182
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264756 Melo-Cardenas J, et al., USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. Blood. 2018 Jul 26;132(4):423-434

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory