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Usp22
Gene Detail
 Symbol
Name
ID
Usp22
ubiquitin specific peptidase 22
MGI:2144157
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:61151785-61175055 bp, - strand
From VEGA annotation of GRCm38

  23271 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Usp22

Human
homologs
Human Homolog USP22, ubiquitin specific peptidase 22
NCBI Gene ID 23326
neXtProt AC  NX_Q9UPT9
Human Synonyms  USP3L
Human Chr (Location)  17p11.2; chr17:20999593-21043409 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Genomic Mutations involving Usp22 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality around E10.5, decreased embryo size, embryonic growth retardation and increased apoptosis in mouse embryonic fibroblast.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Usp22 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell cycle, chromatin modification, ...
Component nucleus, SAGA complex, ...
Function cysteine-type peptidase activity, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (204)    Tissues (85)    Images (54)
Theiler Stages: 6, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 173
Northern blot 31
cDNA source data(179)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(183) cDNA(181) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005825 (Evidence)
Ensembl Gene ModelENSMUSG00000042506 (Evidence)
Entrez Gene216825 (Evidence)
UniGene30602
DFCITC1574787, TC1597100
DoTSDT.484881, DT.97409353
NIA Mouse Gene IndexU032879
EC3.4.19.12
Consensus CDS ProjectCCDS24807.1
International Mouse Knockout Project StatusUsp22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005825 VEGA Gene Model | MGI Sequence Detail 23271 C57BL/6J ±  kb
transcript OTTMUST00000012927 VEGA | MGI Sequence Detail 4434 Not Applicable 
polypeptide OTTMUSP00000006014 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001607 Zinc finger, UBP-type
Protein Ontology PR:000017161 ubiquitin carboxyl-terminal hydrolase 22
References (Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:188021 Lin Z, et al., USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory