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Smg6 Gene Detail
Summary
  • Symbol
    Smg6
  • Name
    Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144117
    NCBI Gene: 103677
  • Gene Overview
    MyGene.info: SMG6
Location & Maps
more
  • Sequence Map
    Chr11:74925823-75164448 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      238626 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SMG6, SMG6, nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMG6, SMG6, nonsense mediated mRNA decay factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C17orf31, EST1A, hSMG5/7a, SMG-6
  • Links
    NCBI Gene ID: 23293
    neXtProt AC: NX_Q86US8

  • Chr Location
    17p13.3; chr17:2059839-2303813 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23024
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SMG6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    62
  • Chemically induced (other)
    1
  • Gene trapped
    55
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Smg6
  • Incidental Mutations
Homozygosity for insertion of a transgene into intron 6 of the gene results in embryonic lethality. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice homozygous for a conditional allele activated in embryonic stem cells exhibit defective telomere maintenance and NMD.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006198 VEGA Gene Model | MGI Sequence Detail 238626 C57BL/6J ±  kb
transcript OTTMUST00000013971 VEGA | MGI Sequence Detail 5848 Not Applicable  
polypeptide OTTMUSP00000006490 VEGA | MGI Sequence Detail 1418 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    727 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    Genomic 1
    cDNA 10

    Microarray probesets 6
Other
Accession IDs
less
MGI:2144427
References
more
  • Summaries
    All 36
    Gene Ontology 3
    Phenotypes 20
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:222980 Li T, et al., Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J. 2015 Jun 12;34(12):1630-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory