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Fbxw11 Gene Detail
Summary
  • Symbol
    Fbxw11
  • Name
    F-box and WD-40 domain protein 11
  • Synonyms
    2310065A07Rik, BTRC2, BTRCP2, Fbxw1b, HOS, mKIAA0696
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144023
    NCBI Gene: 103583
  • Gene Overview
    MyGene.info: FBXW11
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:32642724-32746816 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144023
 protein coding gene Chr11:32642555-32746816 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018138
 protein coding gene Chr11:30886091-30998424 (+)
A/J MGP_AJ_G0018111
 protein coding gene Chr11:29708689-29817406 (+)
AKR/J MGP_AKRJ_G0018075
 protein coding gene Chr11:30642852-30754719 (+)
BALB/cJ MGP_BALBcJ_G0018080
 protein coding gene Chr11:29896515-30000773 (+)
C3H/HeJ MGP_C3HHeJ_G0017893
 protein coding gene Chr11:30589429-30699351 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018534
 protein coding gene Chr11:31891277-32003966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016189
 protein coding gene Chr11:28233007-28342581 (+)
CAST/EiJ MGP_CASTEiJ_G0017457
 protein coding gene Chr11:30632487-30747341 (+)
CBA/J MGP_CBAJ_G0017866
 protein coding gene Chr11:33405369-33525999 (+)
DBA/2J MGP_DBA2J_G0017976
 protein coding gene Chr11:29497692-29601337 (+)
FVB/NJ MGP_FVBNJ_G0017970
 protein coding gene Chr11:29322234-29430128 (+)
LP/J MGP_LPJ_G0018048
 protein coding gene Chr11:31148421-31256111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017994
 protein coding gene Chr11:34390044-34502982 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018573
 protein coding gene Chr11:30783269-30898315 (+)
PWK/PhJ MGP_PWKPhJ_G0017238
 protein coding gene Chr11:29661544-29765426 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017030
 protein coding gene Chr11:30484803-30594800 (+)
WSB/EiJ MGP_WSBEiJ_G0017506
 protein coding gene Chr11:30414445-30523484 (+)



Homology
more
  • Human Ortholog
    FBXW11, F-box and WD repeat domain containing 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FBXW11, F-box and WD repeat domain containing 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTRC2, BTRCP2, Fbw11, FBW1B, FBXW1B, Hos
  • Links
    NCBI Gene ID: 23291
    neXtProt AC: NX_Q9UKB1
    UniProt: Q9UKB1

  • Chr Location
    5q35.1; chr5:171861549-172006873 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from multigenic genotypes
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    24
  • Tissues
    15
  • cDNA Data
    17
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020271 Ensembl Gene Model | MGI Sequence Detail 104093 C57BL/6J ±  kb
transcript ENSMUST00000076383 Ensembl | MGI Sequence Detail 4019 Not Applicable  
polypeptide ENSMUSP00000075721 Ensembl | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919630
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:270079 Morohoshi A, et al., The ubiquitin ligase subunit beta-TrCP in Sertoli cells is essential for spermatogenesis in mice. Dev Biol. 2019 Jan 15;445(2):178-188
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/26/2019
MGI 6.14 		The Jackson Laboratory