Fbxw11 MGI Mouse Gene Detail - MGI:2144023 - F-box and WD-40 domain protein 11

Symbol

Fbxw11
Name

F-box and WD-40 domain protein 11
Synonyms

2310065A07Rik, BTRC2, BTRCP2, Fbxw1b, HOS, mKIAA0696

Feature Type

protein coding gene
IDs

MGI:2144023
NCBI Gene: 103583
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:32592724-32696816 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 19.02 cM
Mapping Data

2 experiments

SNPs within 2kb

2286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144023	protein coding gene	Chr11:32592595-32696816 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018138	protein coding gene	Chr11:30886091-30998424 (+)
A/J	MGP_AJ_G0018111	protein coding gene	Chr11:29708689-29817406 (+)
AKR/J	MGP_AKRJ_G0018075	protein coding gene	Chr11:30642852-30754719 (+)
BALB/cJ	MGP_BALBcJ_G0018080	protein coding gene	Chr11:29896515-30000773 (+)
C3H/HeJ	MGP_C3HHeJ_G0017893	protein coding gene	Chr11:30589429-30699351 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018534	protein coding gene	Chr11:31891277-32003966 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016189	protein coding gene	Chr11:28233007-28342581 (+)
CAST/EiJ	MGP_CASTEiJ_G0017457	protein coding gene	Chr11:30632487-30747341 (+)
CBA/J	MGP_CBAJ_G0017866	protein coding gene	Chr11:33405369-33525999 (+)
DBA/2J	MGP_DBA2J_G0017976	protein coding gene	Chr11:29497692-29601337 (+)
FVB/NJ	MGP_FVBNJ_G0017970	protein coding gene	Chr11:29322234-29430128 (+)
LP/J	MGP_LPJ_G0018048	protein coding gene	Chr11:31148421-31256111 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017994	protein coding gene	Chr11:34390044-34502982 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018573	protein coding gene	Chr11:30783269-30898315 (+)
PWK/PhJ	MGP_PWKPhJ_G0017238	protein coding gene	Chr11:29661544-29765426 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017030	protein coding gene	Chr11:30484803-30594800 (+)
WSB/EiJ	MGP_WSBEiJ_G0017506	protein coding gene	Chr11:30414445-30523484 (+)

Human Ortholog

FBXW11, F-box and WD repeat domain containing 11

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXW11, F-box and WD repeat domain containing 11
Synonyms

BTRC2, BTRCP2, Fbw11, FBW1B, FBXW1B, Hos, NEDJED
Links

HGNC:13607

NCBI Gene ID: 23291

UniProt: Q9UKB1
Chr Location

5q35.1; chr5:171861549-172006873 (-) GRCh38

MGI Vertebrate Homology

Fbxw11 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FBXW11
Gene Tree

Fbxw11

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

58
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

45
Targeted

7
Genomic Mutations

1 involving Fbxw11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

72 strains or lines available

Mice homozygous for a knock-out allele exhibit embryonic growth arrest and complete embryonic lethality before E10.5.

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All GO Annotations

60
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

18
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FBXW11

ZFIN fbxw11a, fbxw11b

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All Sequences

92
RefSeq

16
UniProt

4
CCDS

CCDS36125.1, CCDS70157.1, CCDS70158.1

Ensembl

ENSMUSG00000020271 (Evidence)
NCBI Gene

103583

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020271	Ensembl Gene Model \| MGI Sequence Detail	104093	C57BL/6J	± kb
transcript	ENSMUST00000076383	Ensembl \| MGI Sequence Detail	4019	Not Applicable
polypeptide	ENSMUSP00000075721	Ensembl \| MGI Sequence Detail	563	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007422 F-box/WD repeat-containing protein 11

(term hierarchy)
InterPro Domains

IPR021977 D domain of beta-TrCP

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050995 WD repeat and F-box domain-containing protein

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All nucleic 20

cDNA 17

Primer pair 3

Microarray probesets 4

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MGI:1919630

Summaries

All 61

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:305766 Sun J, et al., FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-beta plaque formation via repression of ASK1 signaling. Biochem Biophys Res Commun. 2021 Apr 9;548:104-111

TSS for Fbxw11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100869	Chr11:32592518-32592537 (+)	-196 bp
Tssr100870	Chr11:32592706-32592821 (+)	40 bp
Tssr100871	Chr11:32592826-32592841 (+)	110 bp
Tssr100872	Chr11:32624487-32624491 (+)	31,765 bp
Tssr100873	Chr11:32632947-32632952 (+)	40,226 bp
Tssr100875	Chr11:32694919-32694935 (+)	102,203 bp
Tssr100876	Chr11:32695462-32695499 (+)	102,757 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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