Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of non-canonical NF-kappaB signal transduction; and protein polyubiquitination. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system and yolk sac. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11).