About   Help   FAQ
Gls2 Gene Detail
Summary
  • Symbol
    Gls2
  • Name
    glutaminase 2 (liver, mitochondrial)
  • Synonyms
    A330074B06Rik, Lga
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143539
    NCBI Gene: 216456
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128194635-128210004 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143539
protein coding gene Chr10:128194457-128210004 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017850
protein coding gene Chr10:131898206-131914536 (+)
A/J MGP_AJ_G0017825
protein coding gene Chr10:126614638-126630185 (+)
AKR/J MGP_AKRJ_G0017788
protein coding gene Chr10:130334683-130349898 (+)
BALB/cJ MGP_BALBcJ_G0017789
protein coding gene Chr10:126985437-127000719 (+)
C3H/HeJ MGP_C3HHeJ_G0017612
protein coding gene Chr10:130483398-130502870 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018244
protein coding gene Chr10:136372980-136388362 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015922
protein coding gene Chr10:120556049-120572073 (+)
CAST/EiJ MGP_CASTEiJ_G0017173
protein coding gene Chr10:131195509-131212296 (+)
CBA/J MGP_CBAJ_G0017582
protein coding gene Chr10:141911194-141926957 (+)
DBA/2J MGP_DBA2J_G0017688
protein coding gene Chr10:125677220-125692574 (+)
FVB/NJ MGP_FVBNJ_G0017683
protein coding gene Chr10:124606071-124621667 (+)
LP/J MGP_LPJ_G0017762
protein coding gene Chr10:132498422-132515261 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017711
protein coding gene Chr10:144509167-144526364 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018284
protein coding gene Chr10:130429344-130446387 (+)
PWK/PhJ MGP_PWKPhJ_G0016958
protein coding gene Chr10:125925107-125941156 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016747
protein coding gene Chr10:129516908-129533319 (+)
WSB/EiJ MGP_WSBEiJ_G0017232
protein coding gene Chr10:130642252-130657567 (+)



Homology
more
  • Human Ortholog
    GLS2, glutaminase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLS2, glutaminase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GA, GLS, hLGA, LGA
  • Links
    NCBI Gene ID: 27165
    neXtProt AC: NX_Q9UI32
    UniProt: Q9UI32

  • Chr Location
    12q13.3; chr12:56470944-56488414 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 40861
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 216456 NCBI Gene Model | MGI Sequence Detail 15370 C57BL/6J ±  kb
transcript NM_001285779 RefSeq | MGI Sequence Detail 2489 C57BL/6  
polypeptide Q571F8 UniProt | EBI | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory