Gls2 MGI Mouse Gene Detail - MGI:2143539 - glutaminase 2 (liver, mitochondrial)

Symbol

Gls2
Name

glutaminase 2 (liver, mitochondrial)
Synonyms

A330074B06Rik, Lga

Feature Type

protein coding gene
IDs

MGI:2143539
NCBI Gene: 216456
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:128030504-128045873 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.44 cM
Mapping Data

2 experiments

SNPs within 2kb

445 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143539	protein coding gene	Chr10:128030326-128045873 (+)
129S1/SvImJ	ENSMUSG00200011624	protein coding gene	Chr10:124383918-124399336 (+)
A/J	ENSMUSG00195015348	protein coding gene	Chr10:124847159-124862579 (+)
AKR/J	ENSMUSG00220005047	protein coding gene	Chr10:124452776-124468198 (+)
BALB/cJ	ENSMUSG00180009928	protein coding gene	Chr10:124838134-124853553 (+)
C3H/HeJ	ENSMUSG00175005908	protein coding gene	Chr10:124837574-124853147 (+)
C57BL/6NJ	ENSMUSG00215006481	protein coding gene	Chr10:124448726-124464209 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015922	protein coding gene	Chr10:120556049-120572073 (+)
CAST/EiJ	ENSTCUG00005034937	protein coding gene	Chr10:123836226-123851590 (+)
CBA/J	ENSMUSG00210008832	protein coding gene	Chr10:124661800-124677373 (+)
DBA/2J	ENSMUSG00185023932	protein coding gene	Chr10:124816094-124831545 (+)
FVB/NJ	ENSMUSG00205018056	protein coding gene	Chr10:124057862-124073439 (+)
JF1/MsJ	ENSUMUG00000018189	protein coding gene	Chr10:126124113-126140120 (+)
LP/J	ENSMUSG00230032211	protein coding gene	Chr10:126737838-126753259 (+)
NOD/ShiLtJ	ENSMUSG00190013985	protein coding gene	Chr10:124879722-124895202 (+)
NZO/HlLtJ	ENSMUSG00225036881	protein coding gene	Chr10:130940271-130955851 (+)
PWK/PhJ	ENSLUMG00010008853	protein coding gene	Chr10:124576481-124592207 (+)
SPRET/EiJ	ENSMSPG00010029220	protein coding gene	Chr10:126540611-126556880 (+)
WSB/EiJ	ENSIUOG00005007856	protein coding gene	Chr10:124454144-124469579 (+)

Human Ortholog

GLS2, glutaminase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLS2, glutaminase 2
Synonyms

GA, GLS, hLGA, LGA
Links

HGNC:29570

NCBI Gene ID: 27165

UniProt: Q9UI32
Chr Location

12q13.3; chr12:56470945-56488414 (-) GRCh38

MGI Vertebrate Homology

Gls2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GLS2
Gene Tree

Gls2

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

76
Endonuclease-mediated

7
Gene trapped

66
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice for a null allele exhibit increased fasting plasma glucagon and glutamine levels with lower fasting blood glucose levels, decreased hepatic glucose production in response to glucagon or lactate and glutamine and pancreatic alpha cell hyperplasia.

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All GO Annotations

16
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

149
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gls2

ZFIN gls2a, gls2b

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All Sequences

60
RefSeq

6
UniProt

7
CCDS

CCDS24263.1

Ensembl

ENSMUSG00000044005 (Evidence)
NCBI Gene

216456

			Length	Strain/Species	Flank
genomic	216456	NCBI Gene Model \| MGI Sequence Detail	15370	C57BL/6J	± kb
transcript	NM_001285779	RefSeq \| MGI Sequence Detail	2489	C57BL/6
polypeptide	Q571F8	UniProt \| EBI \| MGI Sequence Detail	602	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000008052 glutaminase liver isoform, mitochondrial

(term hierarchy)
EC

3.5.1.2
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR012338 Beta-lactamase/transpeptidase-like

IPR015868 Glutaminase

IPR041541 Glutaminase, EF-hand domain
GlyGen

Q571F8 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 3

Summaries

All 68

Developmental Gene Expression 8

Gene Ontology 11

Phenotypes 20
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:388079 Raven A, et al., Hepatic zonation determines tumorigenic potential of mutant beta-catenin. Nature. 2026 Jan;649(8097):739-748

TSS for Gls2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96352	Chr10:128030315-128030335 (+)	-179 bp
Tssr96353	Chr10:128030471-128030482 (+)	-27 bp
Tssr96354	Chr10:128030500-128030536 (+)	14 bp
Tssr96355	Chr10:128030545-128030556 (+)	47 bp
Tssr96356	Chr10:128030590-128030624 (+)	103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24