About   Help   FAQ
Dis3l Gene Detail
Summary
  • Symbol
    Dis3l
  • Name
    DIS3 like exosome 3'-5' exoribonuclease
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143272
    NCBI Gene: 213550
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64214038-64248570 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    913 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143272
 protein coding gene Chr9:64214038-64248707 (-)
129S1/SvImJ ENSMUSG00200041088
 protein coding gene Chr9:61316619-61351411 (-)
A/J ENSMUSG00195025574
 protein coding gene Chr9:61029481-61064393 (-)
AKR/J ENSMUSG00220034090
 protein coding gene Chr9:61176634-61211467 (-)
BALB/cJ ENSMUSG00180016573
 protein coding gene Chr9:61164299-61199114 (-)
C3H/HeJ ENSMUSG00175011643
 protein coding gene Chr9:61163259-61198169 (-)
C57BL/6NJ ENSMUSG00215029955
 protein coding gene Chr9:61151406-61186221 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032344
 protein coding gene Chr9:61470607-61505170 (-)
CAST/EiJ ENSTCUG00005029383
 protein coding gene Chr9:61069221-61104225 (-)
CBA/J ENSMUSG00210013616
 protein coding gene Chr9:61247726-61282631 (-)
DBA/2J ENSMUSG00185029518
 protein coding gene Chr9:61270946-61305865 (-)
FVB/NJ ENSMUSG00205019546
 protein coding gene Chr9:61600105-61635024 (-)
JF1/MsJ ENSUMUG00000011773
 protein coding gene Chr9:61330933-61365458 (-)
LP/J ENSMUSG00230020350
 protein coding gene Chr9:61515747-61550541 (-)
NOD/ShiLtJ ENSMUSG00190018753
 protein coding gene Chr9:61357017-61391884 (-)
NZO/HlLtJ ENSMUSG00225044783
 protein coding gene Chr9:61584269-61619180 (-)
PWK/PhJ ENSLUMG00010025460
 protein coding gene Chr9:61297397-61331763 (-)
SPRET/EiJ ENSMSPG00010019583
 protein coding gene Chr9:62354960-62388804 (-)
WSB/EiJ ENSIUOG00005024476
 protein coding gene Chr9:60760919-60795659 (-)



Homology
more
  • Human Ortholog
    DIS3L, DIS3 like exosome 3'-5' exoribonuclease
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIS3L, DIS3 like exosome 3'-5' exoribonuclease
  • Synonyms
    DIS3L1
  • Links
    NCBI Gene ID: 115752
    UniProt: Q8TF46

  • Chr Location
    15q22.31; chr15:66293217-66333898 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show severe embryo degeneration, inhibition of global protein synthesis, and complete embryonic lethality between implantation and somite formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032396 Ensembl Gene Model | MGI Sequence Detail 34533 C57BL/6J ±  kb
    transcript ENSMUST00000168844 Ensembl | MGI Sequence Detail 3575 Not Applicable  
    polypeptide ENSMUSP00000129772 Ensembl | MGI Sequence Detail 1053 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:365445 Brouze M, et al., DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice. RNA. 2025 Feb 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory