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Dis3l
Gene Detail
 Symbol
Name
ID
Dis3l
DIS3 mitotic control homolog (S. cerevisiae)-like
MGI:2143272
Feature Type protein coding gene
Genetic Map
Chromosome 9
34.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:64306757-64341288 bp, - strand
From VEGA annotation of GRCm38

  34532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15797  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mitotic control protein Dis3
Gene Tree: Dis3l

Human
homologs
Human Homolog DIS3L, DIS3 like exosome 3'-5' exoribonuclease
NCBI Gene ID 115752
neXtProt AC  NX_Q8TF46
Human Synonyms  DIS3L1
Human Chr (Location)  15q22.31; chr15:66293278-66333898 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dis3l interacts with 65 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process RNA phosphodiester bond hydrolysis, exonucleolytic, rRNA catabolic process
Component cytoplasm, cytoplasmic exosome (RNase complex), ...
Function 3'-5'-exoribonuclease activity, 5'-3' exoribonuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031812 (Evidence)
Ensembl Gene ModelENSMUSG00000032396 (Evidence)
Entrez Gene213550 (Evidence)
UniGene268341
DFCITC1580495, TC1594297, TC1640923
DoTSDT.101174643, DT.101735814, DT.40158455, DT.91564275
NIA Mouse Gene IndexU030995
EC3.1.13.-
Consensus CDS ProjectCCDS23280.1, CCDS52832.1
International Mouse Knockout Project StatusDis3l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031812 VEGA Gene Model | MGI Sequence Detail 34532 C57BL/6J ±  kb
transcript OTTMUST00000078851 VEGA | MGI Sequence Detail 3605 Not Applicable 
polypeptide OTTMUSP00000041976 VEGA | MGI Sequence Detail 970 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022966 Ribonuclease II/R, conserved site
Protein Ontology PR:000006492 DIS3-like exonuclease 1
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory