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Dis3l
Gene Detail
Symbol

Name
ID
Dis3l
DIS3 mitotic control homolog (S. cerevisiae)-like
MGI:2143272
Feature Type
protein coding gene
Genetic Map
Chromosome 9
34.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:64306757-64341288 bp, - strand
From VEGA annotation of GRCm38

  34532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15797  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DIS3L
Protein SuperFamily: mitotic control protein Dis3
Gene Tree: Dis3l

Human
homologs
DIS3L, DIS3 like exosome 3'-5' exoribonuclease
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 115752
neXtProt AC: NX_Q8TF46

Human Synonyms: DIS3L1

Human Chr (Location): 15q22.31; chr15:66293256-66333898 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Dis3l interacts with 65 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process mRNA catabolic process, RNA phosphodiester bond hydrolysis, exonucleolytic, ...
Component centrosome, cytoplasm, ...
Function 3'-5'-exoribonuclease activity, 5'-3' exoribonuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dis3l    NEW 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031812 (Evidence)
Ensembl Gene Model ENSMUSG00000032396 (Evidence)
Entrez Gene 213550 (Evidence)
UniGene 268341
DFCI TC1640923, TC1580495, TC1594297
DoTS DT.101174643, DT.91564275, DT.40158455, DT.101735814
NIA Mouse Gene Index U030995
EC 3.1.13.-
Consensus CDS Project CCDS23280.1, CCDS52832.1
International Mouse Phenotyping Consortium Status Dis3l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031812 VEGA Gene Model | MGI Sequence Detail 34532 C57BL/6J ±  kb
transcript OTTMUST00000078851 VEGA | MGI Sequence Detail 3605 Not Applicable 
polypeptide OTTMUSP00000041976 VEGA | MGI Sequence Detail 970 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022966 Ribonuclease II/R, conserved site
Protein Ontology PR:000006492 DIS3-like exonuclease 1
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory