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Dis3l Gene Detail
Summary
  • Symbol
    Dis3l
  • Name
    DIS3 like exosome 3'-5' exoribonuclease
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143272
    NCBI Gene: 213550
  • Gene Overview
    MyGene.info: DIS3L
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64306756-64341288 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 34.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143272
protein coding gene Chr9:64306756-64341426 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034941
protein coding gene Chr9:63974700-64009618 (-)
A/J MGP_AJ_G0034921
protein coding gene Chr9:61828736-61865484 (-)
AKR/J MGP_AKRJ_G0034851
protein coding gene Chr9:63267228-63302111 (-)
BALB/cJ MGP_BALBcJ_G0034914
protein coding gene Chr9:61552921-61589130 (-)
C3H/HeJ MGP_C3HHeJ_G0034624
protein coding gene Chr9:63793797-63833109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035433
protein coding gene Chr9:65717078-65755953 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032344
protein coding gene Chr9:61470607-61505170 (-)
CAST/EiJ MGP_CASTEiJ_G0033945
protein coding gene Chr9:63956360-63994391 (-)
CBA/J MGP_CBAJ_G0034595
protein coding gene Chr9:67970575-68016823 (-)
DBA/2J MGP_DBA2J_G0034754
protein coding gene Chr9:61610971-61646864 (-)
FVB/NJ MGP_FVBNJ_G0034696
protein coding gene Chr9:60911663-60947089 (-)
LP/J MGP_LPJ_G0034837
protein coding gene Chr9:64253934-64289065 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034738
protein coding gene Chr9:69277141-69311978 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035455
protein coding gene Chr9:63377066-63416914 (-)
PWK/PhJ MGP_PWKPhJ_G0033649
protein coding gene Chr9:61766637-61801141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033483
protein coding gene Chr9:63657335-63692400 (-)
WSB/EiJ MGP_WSBEiJ_G0034058
protein coding gene Chr9:63268929-63310075 (-)



Homology
more
  • Human Ortholog
    DIS3L, DIS3 like exosome 3'-5' exoribonuclease
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DIS3L, DIS3 like exosome 3'-5' exoribonuclease
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIS3L1
  • Links
    NCBI Gene ID: 115752
    neXtProt AC: NX_Q8TF46
    UniProt: Q8TF46

  • Chr Location
    15q22.31; chr15:66293257-66333898 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032396 Ensembl Gene Model | MGI Sequence Detail 34533 C57BL/6J ±  kb
transcript ENSMUST00000168844 Ensembl | MGI Sequence Detail 3575 Not Applicable  
polypeptide ENSMUSP00000129772 Ensembl | MGI Sequence Detail 1053 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory