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Dis3l Gene Detail
Summary
  • Symbol
    Dis3l
  • Name
    DIS3 like exosome 3'-5' exoribonuclease
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143272
    NCBI Gene: 213550
  • Gene Overview
    MyGene.info: DIS3L
Location & Maps
more
  • Sequence Map
    Chr9:64306757-64341288 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34532 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 34.62 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DIS3L, DIS3 like exosome 3'-5' exoribonuclease
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DIS3L, DIS3 like exosome 3'-5' exoribonuclease
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DIS3L1
  • Links
    NCBI Gene ID: 115752
    neXtProt AC: NX_Q8TF46

  • Chr Location
    15q22.31; chr15:66293256-66333898 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Genomic Mutations
    1 involving Dis3l
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031812 VEGA Gene Model | MGI Sequence Detail 34532 C57BL/6J ±  kb
transcript OTTMUST00000078851 VEGA | MGI Sequence Detail 3605 Not Applicable  
polypeptide OTTMUSP00000041976 VEGA | MGI Sequence Detail 970 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    237 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory