Whsc1l1
Gene Detail

Symbol Name ID

Whsc1l1 Wolf-Hirschhorn syndrome candidate 1-like 1 (human) MGI:2142581

Synonyms

WHISTLE

Feature Type

protein coding gene

Genetic Map

Chromosome 8

14.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:25601601-25719667 bp, + strand From VEGA annotation of GRCm38   118067 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Whsc1l1

Human homologs

Human Homolog		WHSC1L1, Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Gene ID		54904
neXtProt AC		NX_Q9BZ95
Human Synonyms		NSD3, pp14328
Human Chr (Location)		8p11.2; chr8:38132560-38239790 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WHSC1L1

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	chromatin modification, histone lysine methylation, ...
Component	chromosome, nucleus
Function	histone-lysine N-methyltransferase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(17) Other(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000032895 (Evidence)
Ensembl Gene Model	ENSMUSG00000054823 (Evidence)
Entrez Gene	234135 (Evidence)
DFCI	TC1579341, TC1603828, TC1650891, TC1708692
DoTS	DT.102552677, DT.40152864, DT.40158388, DT.87043077, DT.94163880, DT.94297872, DT.97352067
NIA Mouse Gene Index	U009197
EC	2.1.1.43
Consensus CDS Project	CCDS40305.1, CCDS52528.1
International Mouse Knockout Project Status	Whsc1l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032895	VEGA Gene Model | MGI Sequence Detail	118067	C57BL/6J
transcript	OTTMUST00000081971	VEGA | MGI Sequence Detail	10105	Not Applicable
polypeptide	OTTMUSP00000043907	VEGA | MGI Sequence Detail	1446	Not Applicable

All sequences(76) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006560	AWS
InterPro	IPR003616	Post-SET domain
InterPro	IPR000313	PWWP
InterPro	IPR001214	SET domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000017418	histone-lysine N-methyltransferase NSD3

References

(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:183391 Mann KM, et al., Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41
All references(37)