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Whsc1l1
Gene Detail
Symbol

Name
ID
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
MGI:2142581
Synonyms
WHISTLE
Feature Type
protein coding gene
Genetic Map
Chromosome 8
14.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:25601601-25719667 bp, + strand
From VEGA annotation of GRCm38

  118067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: WHSC1L1
Gene Tree: Whsc1l1

Human
homologs
WHSC1L1, Wolf-Hirschhorn syndrome candidate 1-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54904
neXtProt AC: NX_Q9BZ95

Human Synonyms: NSD3, pp14328

Human Chr (Location): 8p11.2; chr8:38269699-38382354 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Whsc1l1 interacts with 474 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase whsc1l1 ; ZFIN whsc1l1    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000032895 (Evidence)
Ensembl Gene Model ENSMUSG00000054823 (Evidence)
Entrez Gene 234135 (Evidence)
DFCI TC1708692, TC1650891, TC1603828, TC1579341
DoTS DT.94163880, DT.102552677, DT.87043077, DT.40152864, DT.40158388, DT.97352067, DT.94297872
NIA Mouse Gene Index U009197
EC 2.1.1.43
Consensus CDS Project CCDS40305.1, CCDS52528.1
International Mouse Phenotyping Consortium Status Whsc1l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032895 VEGA Gene Model | MGI Sequence Detail 118067 C57BL/6J ±  kb
transcript OTTMUST00000081971 VEGA | MGI Sequence Detail 10105 Not Applicable 
polypeptide OTTMUSP00000043907 VEGA | MGI Sequence Detail 1446 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006560 AWS
InterPro IPR003616 Post-SET domain
InterPro IPR000313 PWWP
InterPro IPR001214 SET domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000017418 histone-lysine N-methyltransferase NSD3
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:183391 Mann KM, et al., Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory