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Whsc1l1
Gene Detail
 Symbol
Name
ID
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
MGI:2142581
Synonyms WHISTLE
Feature Type protein coding gene
Genetic Map
Chromosome 8
14.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:25601601-25719667 bp, + strand
From VEGA annotation of GRCm38

  118067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Whsc1l1

Human
homologs
Human Homolog WHSC1L1, Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Gene ID 54904
neXtProt AC  NX_Q9BZ95
Human Synonyms  NSD3, pp14328
Human Chr (Location)  8p11.2; chr8:38269699-38382354 (-)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process chromatin modification, histone lysine methylation, ...
Component chromosome, nucleus
Function histone-lysine N-methyltransferase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(17) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000032895 (Evidence)
Ensembl Gene ModelENSMUSG00000054823 (Evidence)
Entrez Gene234135 (Evidence)
DFCITC1579341, TC1603828, TC1650891, TC1708692
DoTSDT.40152864, DT.102552677, DT.40158388, DT.87043077, DT.94163880, DT.94297872, DT.97352067
NIA Mouse Gene IndexU009197
EC2.1.1.43
Consensus CDS ProjectCCDS40305.1, CCDS52528.1
International Mouse Knockout Project StatusWhsc1l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032895 VEGA Gene Model | MGI Sequence Detail 118067 C57BL/6J ±  kb
transcript OTTMUST00000081971 VEGA | MGI Sequence Detail 10105 Not Applicable 
polypeptide OTTMUSP00000043907 VEGA | MGI Sequence Detail 1446 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(16) UniProt(4)
Polymorphisms SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006560 AWS
InterPro IPR003616 Post-SET domain
InterPro IPR000313 PWWP
InterPro IPR001214 SET domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000017418 histone-lysine N-methyltransferase NSD3
References (Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:183391 Mann KM, et al., Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory