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Nsd3 Gene Detail
Summary
  • Symbol
    Nsd3
  • Name
    nuclear receptor binding SET domain protein 3
  • Synonyms
    WHISTLE, Whsc1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142581
    NCBI Gene: 234135
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26091617-26209694 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142581
protein coding gene Chr8:26091617-26209694 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033483
protein coding gene Chr8:23654798-23786487 (+)
A/J MGP_AJ_G0033463
protein coding gene Chr8:22802512-22922483 (+)
AKR/J MGP_AKRJ_G0033388
protein coding gene Chr8:23549682-23679382 (+)
BALB/cJ MGP_BALBcJ_G0033459
protein coding gene Chr8:22950114-23068917 (+)
C3H/HeJ MGP_C3HHeJ_G0033173
protein coding gene Chr8:23770228-23892230 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033975
protein coding gene Chr8:24617254-24752563 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030925
protein coding gene Chr8:20073120-20192585 (+)
CAST/EiJ MGP_CASTEiJ_G0032499
protein coding gene Chr8:23209298-23341186 (+)
CBA/J MGP_CBAJ_G0033148
protein coding gene Chr8:25577251-25720478 (+)
DBA/2J MGP_DBA2J_G0033303
protein coding gene Chr8:22774795-22893249 (+)
FVB/NJ MGP_FVBNJ_G0033247
protein coding gene Chr8:22581815-22699766 (+)
LP/J MGP_LPJ_G0033392
protein coding gene Chr8:23642542-23764411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033290
protein coding gene Chr8:25035268-25175220 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033994
protein coding gene Chr8:23491138-23613893 (+)
PWK/PhJ MGP_PWKPhJ_G0032210
protein coding gene Chr8:22411257-22534759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032044
protein coding gene Chr8:22856131-22983909 (+)
WSB/EiJ MGP_WSBEiJ_G0032615
protein coding gene Chr8:23711290-23833373 (+)



Homology
more
  • Human Ortholog
    NSD3, nuclear receptor binding SET domain protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSD3, nuclear receptor binding SET domain protein 3
  • Synonyms
    KMT3F, KMT3G, pp14328, WHISTLE, WHSC1L1
  • Links
    NCBI Gene ID: 54904
    neXtProt AC: NX_Q9BZ95
    UniProt: Q9BZ95

  • Chr Location
    8p11.23; chr8:38269704-38382272 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human NSD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234135 NCBI Gene Model | MGI Sequence Detail 118078 C57BL/6J ±  kb
    transcript NM_001081269 RefSeq | MGI Sequence Detail 9652 C57BL/6  
    polypeptide Q6P2L6 UniProt | EBI | MGI Sequence Detail 1439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 9
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:302098 Yuan G, et al., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature. 2021 Feb;590(7846):504-508

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory