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Nsd3 Gene Detail
Summary
  • Symbol
    Nsd3
  • Name
    nuclear receptor binding SET domain protein 3
  • Synonyms
    WHISTLE, Whsc1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142581
    NCBI Gene: 234135
  • Gene Overview
    MyGene.info: NSD3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:25601601-25719667 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118067 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.17 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NSD3, nuclear receptor binding SET domain protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NSD3, nuclear receptor binding SET domain protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KMT3F, KMT3G, pp14328, WHISTLE, WHSC1L1
  • Links
    NCBI Gene ID: 54904
    neXtProt AC: NX_Q9BZ95
    UniProt: Q9BZ95

  • Chr Location
    8p11.23; chr8:38275042-38382272 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032895 VEGA Gene Model | MGI Sequence Detail 118067 C57BL/6J ±  kb
    transcript OTTMUST00000081971 VEGA | MGI Sequence Detail 10105 Not Applicable  
    polypeptide OTTMUSP00000043907 VEGA | MGI Sequence Detail 1446 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      244 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 9
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:251909 Wang C, et al., The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3. J Exp Med. 2017 Dec 4;214(12):3597-3610

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory