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Crtc1
Gene Detail
 Symbol
Name
ID
Crtc1
CREB regulated transcription coactivator 1
MGI:2142523
Synonyms Mect1, mKIAA0616, TORC1
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:70382355-70439579 bp, - strand
From VEGA annotation of GRCm38

  57225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41607  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Crtc1

Human
homologs
Human Homolog CRTC1, CREB regulated transcription coactivator 1
NCBI Gene ID 23373
neXtProt AC  NX_Q6UUV9
Human Synonyms  MECT1, TORC1, TORC-1, WAMTP1
Human Chr (Location)  19p13.11; chr19:18683615-18782333 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an inactivating mutation in this gene are hyperphagic, obese and infertile.
 
Interactions
Crtc1 interacts with 265 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process entrainment of circadian clock by photoperiod, membrane hyperpolarization, ...
Component cytoplasm, nucleus, ...
Function cAMP response element binding protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 19
Assay TypeResults
RNA in situ 2
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) cDNA(86)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022258 (Evidence)
Ensembl Gene ModelENSMUSG00000003575 (Evidence)
Entrez Gene382056 (Evidence)
UniGene227767
DFCITC1604191, TC1642250
DoTSDT.101219943, DT.492011
NIA Mouse Gene IndexU029915
Consensus CDS ProjectCCDS40372.1
International Mouse Knockout Project StatusCrtc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022258 VEGA Gene Model | MGI Sequence Detail 57225 C57BL/6J ±  kb
transcript OTTMUST00000052982 VEGA | MGI Sequence Detail 5683 Not Applicable 
polypeptide OTTMUSP00000025172 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024786 Transducer of regulated CREB activity
InterPro IPR024785 Transducer of regulated CREB activity, C-terminal
InterPro IPR024784 Transducer of regulated CREB activity, middle domain
InterPro IPR024783 Transducer of regulated CREB activity, N-terminal
Protein Ontology PR:000005901 CREB-regulated transcription coactivator 1
References (Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:210616 Parra-Damas A, et al., Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages. J Neurosci. 2014 Apr 23;34(17):5776-87
All references(41)
Other
accession IDs
MGI:2142895

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory