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Crtc1 Gene Detail
Summary
  • Symbol
    Crtc1
  • Name
    CREB regulated transcription coactivator 1
  • Synonyms
    Mect1, mKIAA0616, TORC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142523
    NCBI Gene: 382056
Location & Maps
more
  • Sequence Map
    Chr8:70382355-70439579 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57225 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CRTC1, CREB regulated transcription coactivator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRTC1, CREB regulated transcription coactivator 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MECT1, TORC1, TORC-1, WAMTP1
  • Links
    NCBI Gene ID: 23373
    neXtProt AC: NX_Q6UUV9

  • Chr Location
    19p13.11; chr19:18683615-18782333 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41607
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CRTC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    1
  • Genomic Mutations
    1 involving Crtc1
  • Incidental Mutations
Mice homozygous for an inactivating mutation in this gene are hyperphagic, obese and infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022258 VEGA Gene Model | MGI Sequence Detail 57225 C57BL/6J ±  kb
transcript OTTMUST00000052982 VEGA | MGI Sequence Detail 5683 Not Applicable  
polypeptide OTTMUSP00000025172 VEGA | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    329 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005901 CREB-regulated transcription coactivator 1
  • InterPro Domains
    IPR024786 CREB-regulated transcription coactivator
    IPR024785 Transducer of regulated CREB activity, C-terminal
    IPR024784 Transducer of regulated CREB activity, middle domain
    IPR024783 Transducer of regulated CREB activity, N-terminal
Molecular
Reagents
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  • All nucleic 86
    cDNA 86

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142895
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
  • Latest
    J:220979 Kim GH, et al., Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Mol Metab. 2015 Mar;4(3):227-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory