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Crtc1
Gene Detail
Symbol

Name
ID
Crtc1
CREB regulated transcription coactivator 1
MGI:2142523
Synonyms
Mect1, mKIAA0616, TORC1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:70382355-70439579 bp, - strand
From VEGA annotation of GRCm38

  57225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41607  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRTC1
Gene Tree: Crtc1

Human
homologs
CRTC1, CREB regulated transcription coactivator 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23373
neXtProt AC: NX_Q6UUV9

Human Synonyms: MECT1, TORC1, TORC-1, WAMTP1

Human Chr (Location): 19p13.11; chr19:18683615-18782333 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an inactivating mutation in this gene are hyperphagic, obese and infertile.
 
Interactions
Crtc1 interacts with 264 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process entrainment of circadian clock by photoperiod, membrane hyperpolarization, ...
Component cytoplasm, dendrite, ...
Function cAMP response element binding protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(86)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crtc1    NEW 
Molecular
reagents
All nucleic(86) cDNA(86)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022258 (Evidence)
Ensembl Gene Model ENSMUSG00000003575 (Evidence)
Entrez Gene 382056 (Evidence)
UniGene 227767
DFCI TC1642250, TC1604191
DoTS DT.492011, DT.101219943
NIA Mouse Gene Index U029915
Consensus CDS Project CCDS40372.1
International Mouse Phenotyping Consortium Status Crtc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022258 VEGA Gene Model | MGI Sequence Detail 57225 C57BL/6J ±  kb
transcript OTTMUST00000052982 VEGA | MGI Sequence Detail 5683 Not Applicable 
polypeptide OTTMUSP00000025172 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(20) UniProt(1)
Polymorphisms
SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024786 Transducer of regulated CREB activity
InterPro IPR024785 Transducer of regulated CREB activity, C-terminal
InterPro IPR024784 Transducer of regulated CREB activity, middle domain
InterPro IPR024783 Transducer of regulated CREB activity, N-terminal
Protein Ontology PR:000005901 CREB-regulated transcription coactivator 1
References
(Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:220979 Kim GH, et al., Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Mol Metab. 2015 Mar;4(3):227-36
All references(46)
Other
accession IDs
MGI:2142895

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory