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Lrtm2 Gene Detail
Summary
  • Symbol
    Lrtm2
  • Name
    leucine-rich repeats and transmembrane domains 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141485
    NCBI Gene: 211187
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119292094-119307727 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    875 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141485
 protein coding gene Chr6:119292094-119315009 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031192
 protein coding gene Chr6:122103006-122118655 (-)
A/J MGP_AJ_G0031161
 protein coding gene Chr6:117435049-117450694 (-)
AKR/J MGP_AKRJ_G0031092
 protein coding gene Chr6:120582298-120597947 (-)
BALB/cJ MGP_BALBcJ_G0031172
 protein coding gene Chr6:117205712-117221357 (-)
C3H/HeJ MGP_C3HHeJ_G0030538
 protein coding gene Chr6:63702005-63717650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031630
 protein coding gene Chr6:125221186-125236819 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028791
 protein coding gene Chr6:114352211-114366264 (-)
CAST/EiJ MGP_CASTEiJ_G0030279
 protein coding gene Chr6:121020892-121036355 (-)
CBA/J MGP_CBAJ_G0030855
 protein coding gene Chr6:130178665-130194310 (-)
DBA/2J MGP_DBA2J_G0031011
 protein coding gene Chr6:116337488-116353137 (-)
FVB/NJ MGP_FVBNJ_G0030963
 protein coding gene Chr6:115460473-115476359 (-)
LP/J MGP_LPJ_G0031090
 protein coding gene Chr6:122117462-122133111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030997
 protein coding gene Chr6:134204731-134220376 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031659
 protein coding gene Chr6:120626723-120642368 (-)
PWK/PhJ MGP_PWKPhJ_G0029994
 protein coding gene Chr6:115342658-115358369 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029823
 protein coding gene Chr6:119336540-119353274 (-)
WSB/EiJ MGP_WSBEiJ_G0030362
 protein coding gene Chr6:120888307-120905108 (-)



Homology
more
  • Human Ortholog
    LRTM2, leucine rich repeat transmembrane protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRTM2, leucine rich repeat transmembrane protein 2
  • Links
    NCBI Gene ID: 654429
    UniProt: Q8N967

  • Chr Location
    12p13.33; chr12:1820267-1836753 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced exploratory behaviors, enhanced coordination, and decreased monoamine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055003 Ensembl Gene Model | MGI Sequence Detail 15634 C57BL/6J ±  kb
    transcript ENSMUST00000068351 Ensembl | MGI Sequence Detail 4001 Not Applicable  
    polypeptide ENSMUSP00000063882 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031711 leucine-rich repeat and transmembrane domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q8BGX3 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:325069 Ichise M, et al., Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics. Front Mol Neurosci. 2022;15:856315
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory