Glmn
Gene Detail

Symbol Name ID

Glmn glomulin, FKBP associated protein MGI:2141180

Synonyms

9330160J16Rik, Fap48, Fap68

Feature Type

protein coding gene

Genetic Map

Chromosome 5

52.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:107548967-107597888 bp, - strand From VEGA annotation of GRCm38   48922 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glmn

Human homologs

Human Homolog		GLMN, glomulin, FKBP associated protein
NCBI Gene ID		11146
neXtProt AC		NX_Q92990
Human Synonyms		FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM
Human Chr (Location)		1p22.1; chr1:92711955-92764566 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GLMN

Alleles and phenotypes

All alleles(8) : Targeted(3) Gene trapped(5)
 

Mice homozygous for a gene trap allele exhibit complete embryonic lethality during organogenesis associated with growth retardation, delayed neural tube closure, incomplete embryo turning, pericardial effusion, disorganized yolk sac vascular plexus and head mesenchyme hypocellularity.

 
Human Diseases Modeled Using Mouse Glmn (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cell surface receptor signaling pathway, circulatory system development, ...
Component	Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, ...
Function	hepatocyte growth factor receptor binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (49)    Images (22)
Theiler Stages: 16, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	54
RT-PCR	4

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023402 (Evidence)
Ensembl Gene Model	ENSMUSG00000029276 (Evidence)
Entrez Gene	170823 (Evidence)
DFCI	TC1581783
DoTS	DT.60118085, DT.94247948
NIA Mouse Gene Index	U026517
Consensus CDS Project	CCDS19505.1, CCDS51587.1
International Mouse Knockout Project Status	Glmn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023402	VEGA Gene Model | MGI Sequence Detail	48922	C57BL/6J
transcript	OTTMUST00000056835	VEGA | MGI Sequence Detail	2015	Not Applicable
polypeptide	OTTMUSP00000027361	VEGA | MGI Sequence Detail	596	Not Applicable

All sequences(56) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019516	Glomulin
InterPro	IPR013877	YAP-binding/Alf4/Glomulin
Protein Ontology	PR:000008037	glomulin

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:184206 Tron AE, et al., The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78
All references(36)