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Glmn
Gene Detail
Symbol

Name
ID
Glmn
glomulin, FKBP associated protein
MGI:2141180
Synonyms
9330160J16Rik, Fap48, Fap68
Feature Type
protein coding gene
Genetic Map
Chromosome 5
52.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:107548967-107597888 bp, - strand
From VEGA annotation of GRCm38

  48922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GLMN
Gene Tree: Glmn

Human
homologs
GLMN, glomulin, FKBP associated protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11146
neXtProt AC: NX_Q92990

Human Synonyms: FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM

Human Chr (Location): 1p22.1; chr1:92246398-92441946 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GLMN

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit complete embryonic lethality during organogenesis associated with growth retardation, delayed neural tube closure, incomplete embryo turning, pericardial effusion, disorganized yolk sac vascular plexus and head mesenchyme hypocellularity.
 
Human Diseases Modeled in Mice Using Glmn (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Glmn interacts with 201 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (49)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
RT-PCR 4
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase glmn ; ZFIN glmna    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023402 (Evidence)
Ensembl Gene Model ENSMUSG00000029276 (Evidence)
Entrez Gene 170823 (Evidence)
DFCI TC1581783
DoTS DT.60118085, DT.94247948
NIA Mouse Gene Index U026517
Consensus CDS Project CCDS19505.1, CCDS51587.1
International Mouse Phenotyping Consortium Status Glmn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023402 VEGA Gene Model | MGI Sequence Detail 48922 C57BL/6J ±  kb
transcript OTTMUST00000056835 VEGA | MGI Sequence Detail 2015 Not Applicable 
polypeptide OTTMUSP00000027361 VEGA | MGI Sequence Detail 596 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019516 Glomulin
InterPro IPR013877 YAP-binding/Alf4/Glomulin
Protein Ontology PR:000008037 glomulin
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:184206 Tron AE, et al., The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78
All references(34)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory