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Fbxl4 Gene Detail
Summary
  • Symbol
    Fbxl4
  • Name
    F-box and leucine-rich repeat protein 4
  • Synonyms
    FBL4, FBL5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140367
    NCBI Gene: 269514
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:22357543-22434091 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 9.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140367
protein coding gene Chr4:22357526-22434091 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028096
protein coding gene Chr4:19419720-19496210 (+)
A/J MGP_AJ_G0028054
protein coding gene Chr4:18846977-18920549 (+)
AKR/J MGP_AKRJ_G0028019
protein coding gene Chr4:19268622-19348181 (+)
BALB/cJ MGP_BALBcJ_G0028065
protein coding gene Chr4:18894608-18968521 (+)
C3H/HeJ MGP_C3HHeJ_G0027795
protein coding gene Chr4:19447654-19518068 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028508
protein coding gene Chr4:20184488-20259345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025850
protein coding gene Chr4:17469671-17543951 (+)
CAST/EiJ MGP_CASTEiJ_G0027250
protein coding gene Chr4:19241680-19320031 (+)
CBA/J MGP_CBAJ_G0027768
protein coding gene Chr4:20781839-20868386 (+)
DBA/2J MGP_DBA2J_G0027911
protein coding gene Chr4:18725378-18797608 (+)
FVB/NJ MGP_FVBNJ_G0027877
protein coding gene Chr4:18411111-18484365 (+)
LP/J MGP_LPJ_G0028020
protein coding gene Chr4:19512028-19589279 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027910
protein coding gene Chr4:22004885-22084690 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028567
protein coding gene Chr4:19221901-19299604 (+)
PWK/PhJ MGP_PWKPhJ_G0026970
protein coding gene Chr4:18552086-18627937 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026799
protein coding gene Chr4:19064600-19141259 (+)
WSB/EiJ MGP_WSBEiJ_G0027327
protein coding gene Chr4:19214029-19289028 (+)



Homology
more
  • Human Ortholog
    FBXL4, F-box and leucine rich repeat protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXL4, F-box and leucine rich repeat protein 4
  • Synonyms
    FBL4, FBL5, MTDPS13
  • Links
    NCBI Gene ID: 26235
    neXtProt AC: NX_Q9UKA2
    UniProt: Q9UKA2

  • Chr Location
    6q16.1-q16.2; chr6:98868535-98948006 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FBXL4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout is mostly pre-weaning lethal but, in surviving mice around 1 year of age, increases mitochondrial turnover, causing weight loss and other morphological and also behavioral changes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040410 Ensembl Gene Model | MGI Sequence Detail 76549 C57BL/6J ±  kb
    transcript ENSMUST00000039234 Ensembl | MGI Sequence Detail 2546 Not Applicable  
    polypeptide ENSMUSP00000042219 Ensembl | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:303084 Alsina D, et al., FBXL4 deficiency increases mitochondrial removal by autophagy. EMBO Mol Med. 2020 Jul 7;12(7):e11659

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/23/2022
    MGI 6.20
    The Jackson Laboratory