Slc35d1 Gene Detail

Summary

• Symbol
  Slc35d1
• Name
  solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
• Synonyms
  UGTREL7

• Feature Type
  protein coding gene
• IDs
  MGI:2140361
  NCBI Gene: 242585

Location & Maps

• Sequence Map
  Chr4:103170649-103215164 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    44516 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 47.43 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  SLC35D1, solute carrier family 35 member D1

• Vertebrate Orthologs
  10

• Human Ortholog
  SLC35D1, solute carrier family 35 member D1
  Orthology source: HomoloGene, HGNC
• Synonyms
  UGTREL7
• Links
  HGNC:20800

  NCBI Gene ID: 23169

  neXtProt AC: NX_Q9NTN3

  UniProt: Q9NTN3

  
  
• Chr Location
  1p31.3; chr1:66999332-67054397 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 22870
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: SLC35D1
• Gene Tree
  Slc35d1
  

Human Diseases

• Diseases
  1 with Slc35d1 mouse models; 1 with human SLC35D1 associations

Human Disease

Mouse Models

schneckenbecken dysplasia

IDs

schneckenbecken dysplasia      

DOID:0050775
OMIM:269250

View 1 model

Mouse Models

Human Disease Modeled: schneckenbecken dysplasia

Allelic Composition	Genetic Background	Reference	Phenotypes
Slc35d1tm1Hko/Slc35d1tm1Hko	involves: 129S1/Sv * 129X1/SvJ	J:130304	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotypes from 1 allele in 1 genetic background
  11 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  2
• Gene trapped
  1
• Radiation induced
  1
• Targeted
  4
• Genomic Mutations
  4 involving Slc35d1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  16 strains or lines available

Mice homozygous for a null allele exhibit neonatal lethality and chondrodystrophy associated with impaired chondroitin sulfate biosynthesis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  2

• External Resources
  FuncBase

Expression

• Assay Results
  1
• Tissues
  1
• cDNA Data
  47
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA SLC35D1
  ZFIN slc35d1a, slc35d1b

Interactions

• Slc35d1 interacts with 291 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

Sequences &
Gene Models

• All Sequences
  42
• RefSeq
  7
• UniProt
  4
• CCDS
  CCDS18409.1
• UniGene
  281800

• VEGA
  OTTMUSG00000008067 (Evidence)
• Ensembl
  ENSMUSG00000028521 (Evidence)
• NCBI Gene
  242585

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000008067	VEGA Gene Model | MGI Sequence Detail	44516	C57BL/6J
transcript	OTTMUST00000018297	VEGA | MGI Sequence Detail	4021	Not Applicable
polypeptide	OTTMUSP00000008412	VEGA | MGI Sequence Detail	334	Not Applicable

Polymorphisms

• SNPs within 2kb
  373 from dbSNP Build 142

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000015098 UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
  (term hierarchy)
• InterPro Domains
  IPR004853 Sugar phosphate transporter domain

Molecular
Reagents

• All nucleic 50

  Genomic 1

  cDNA 48

  Primer pair 1

  
  

  Microarray probesets 3

References

• Summaries
  All 32

  Developmental Gene Expression 2

  Diseases 1

  Gene Ontology 2

  Phenotypes 11
• Earliest
  J:23094 Davisson MT, New chromosome aberrations. Mouse News Lett. 1988;80:166
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582