Slc35d1 MGI Mouse Gene Detail - MGI:2140361 - solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Symbol

Slc35d1
Name

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms

UGTREL7

Feature Type

protein coding gene
IDs

MGI:2140361
NCBI Gene: 242585
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:103170649-103215164 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 47.43 cM
Mapping Data

1 experiment

SNPs within 2kb

373 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140361	protein coding gene	Chr4:103170649-103215368 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028506	protein coding gene	Chr4:103584994-103630177 (-)
A/J	MGP_AJ_G0028469	protein coding gene	Chr4:99970938-100016038 (-)
AKR/J	MGP_AKRJ_G0028416	protein coding gene	Chr4:102397672-102442329 (-)
BALB/cJ	MGP_BALBcJ_G0028488	protein coding gene	Chr4:100168968-100213512 (-)
C3H/HeJ	MGP_C3HHeJ_G0028202	protein coding gene	Chr4:103177145-103222005 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028928	protein coding gene	Chr4:107495277-107539576 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026219	protein coding gene	Chr4:95322463-95366738 (-)
CAST/EiJ	MGP_CASTEiJ_G0027638	protein coding gene	Chr4:100939529-100985459 (-)
CBA/J	MGP_CBAJ_G0028171	protein coding gene	Chr4:110898661-110946634 (-)
DBA/2J	MGP_DBA2J_G0028319	protein coding gene	Chr4:99625007-99669018 (-)
FVB/NJ	MGP_FVBNJ_G0028286	protein coding gene	Chr4:98473280-98517763 (-)
LP/J	MGP_LPJ_G0028420	protein coding gene	Chr4:103864625-103908958 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028313	protein coding gene	Chr4:116343257-116387547 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028963	protein coding gene	Chr4:102611916-102657222 (-)
PWK/PhJ	MGP_PWKPhJ_G0027364	protein coding gene	Chr4:97839420-97884864 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027188	protein coding gene	Chr4:100033168-100073990 (-)
WSB/EiJ	MGP_WSBEiJ_G0027718	protein coding gene	Chr4:102778299-102823677 (-)

Human Ortholog

SLC35D1, solute carrier family 35 member D1

Vertebrate Orthologs

10

Human Ortholog

SLC35D1, solute carrier family 35 member D1
Orthology source: HomoloGene, HGNC
Synonyms

SHNKND, UGTREL7
Links

HGNC:20800

NCBI Gene ID: 23169

neXtProt AC: NX_Q9NTN3

UniProt: Q9NTN3
Chr Location

1p31.3; chr1:66999332-67054397 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22870
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC35D1
Gene Tree

Slc35d1

Diseases

1 with Slc35d1 mouse models; 1 with human SLC35D1 associations

Human Disease

Mouse Models

schneckenbecken dysplasia

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Slc35d1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit neonatal lethality and chondrodystrophy associated with impaired chondroitin sulfate biosynthesis.

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All GO Annotations

16
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Assay Results

1
Tissues

1
cDNA Data

47
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SLC35D1

ZFIN slc35d1a, slc35d1b

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Slc35d1 interacts with 291 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

54
RefSeq

7
UniProt

5
CCDS

CCDS18409.1
UniGene

281800

Ensembl

ENSMUSG00000028521 (Evidence)
NCBI Gene

242585

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028521	Ensembl Gene Model \| MGI Sequence Detail	44516	C57BL/6J	± kb
transcript	ENSMUST00000036195	Ensembl \| MGI Sequence Detail	4021	Not Applicable
polypeptide	ENSMUSP00000037617	Ensembl \| MGI Sequence Detail	334	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015098 UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

(term hierarchy)
InterPro Domains

IPR004853 Sugar phosphate transporter domain

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All nucleic 51

Genomic 2

cDNA 48

Primer pair 1

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 2

Diseases 1

Gene Ontology 3

Phenotypes 12
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Slc35d1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42607	Chr4:103215339-103215389 (-)	-200 bp
Tssr42606	Chr4:103215147-103215201 (-)	-10 bp
Tssr42605	Chr4:103215136-103215141 (-)	25 bp
Tssr42604	Chr4:103214845-103214856 (-)	313 bp
Tssr42603	Chr4:103214791-103214818 (-)	359 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/13/2019 MGI 6.14