Slc35d1^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Slc35d1^tm1Hko
• Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:3774133
• Gene: Slc35d1 Location: Chr4:103027846-103072361 bp, - strand Genetic Position: Chr4, 47.43 cM
• Alliance: Slc35d1^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130304
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR on E18.5 lung extracts. (J:130304)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc35d1 Mutation: 34 strains or lines available

References

• Original: J:130304 Hiraoka S, et al., Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. Nat Med. 2007 Nov;13(11):1363-7
• All: 1 reference(s)