Akna MGI Mouse Gene Detail - MGI:2140340 - AT-hook transcription factor

Akna Gene Detail

Symbol

Akna
Name

AT-hook transcription factor
Synonyms

mKIAA1968

Feature Type

protein coding gene
IDs

MGI:2140340
NCBI Gene: 100182

Sequence Map

Chr4:63367125-63403354 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

36230 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 33.96 cM
Mapping Data

1 experiment

Human Ortholog

AKNA, AT-hook transcription factor

Vertebrate Orthologs

7

Human Ortholog

AKNA, AT-hook transcription factor
Orthology source: HomoloGene, HGNC
Links

HGNC:24108

NCBI Gene ID: 80709

neXtProt AC: NX_Q7Z591

UniProt: Q7Z591
Chr Location

9q32; chr9:114334149-114398498 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 49947
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: AKNA
Gene Tree

Akna

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for a hypomorphic or a knock-out allele exhibit partial postnatal lethality, pathogen-induced acute neutrophil responses leading to systemic inflammation and alveolar destruction, and increased susceptibility to fungal infection.

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All GO Annotations

13
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

238
Tissues

149
cDNA Data

40
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Akna interacts with 163 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

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All Sequences

39
RefSeq

12
UniProt

1
CCDS

CCDS38777.1
UniGene

387725

			Length	Strain/Species	Flank
genomic	OTTMUSG00000014249	VEGA Gene Model \| MGI Sequence Detail	36230	C57BL/6J	± kb
transcript	OTTMUST00000033536	VEGA \| MGI Sequence Detail	5387	Not Applicable
polypeptide	OTTMUSP00000015051	VEGA \| MGI Sequence Detail	1404	Not Applicable

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SNPs within 2kb

361 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000003899 AT-hook-containing transcription factor

(term hierarchy)
InterPro Domains

IPR022150 Transcription factor, AT-hook-containing

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All nucleic 42

Genomic 1

cDNA 40

Primer pair 1

Microarray probesets 4

Summaries

All 32

Developmental Gene Expression 5

Gene Ontology 2

Phenotypes 4
Earliest

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
Latest

J:233952 Ma W, et al., Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov;21(11):1564-77

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/13/2017 MGI 6.10