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Akna Gene Detail
Summary
  • Symbol
    Akna
  • Name
    AT-hook transcription factor
  • Synonyms
    mKIAA1968
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140340
    NCBI Gene: 100182
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63367125-63403354 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140340
 protein coding gene Chr4:63367123-63411094 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028367
 protein coding gene Chr4:62372573-62409362 (-)
A/J MGP_AJ_G0028328
 protein coding gene Chr4:60130232-60167497 (-)
AKR/J MGP_AKRJ_G0028278
 protein coding gene Chr4:61770668-61807495 (-)
BALB/cJ MGP_BALBcJ_G0028348
 protein coding gene Chr4:60318935-60355923 (-)
C3H/HeJ MGP_C3HHeJ_G0028064
 protein coding gene Chr4:62295798-62332578 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028788
 protein coding gene Chr4:64512324-64550242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026091
 protein coding gene Chr4:57482855-57519524 (-)
CAST/EiJ MGP_CASTEiJ_G0027502
 protein coding gene Chr4:60274577-60311082 (-)
CBA/J MGP_CBAJ_G0028033
 protein coding gene Chr4:66774903-66813384 (-)
DBA/2J MGP_DBA2J_G0028182
 protein coding gene Chr4:59984091-60020775 (-)
FVB/NJ MGP_FVBNJ_G0028147
 protein coding gene Chr4:59258926-59298462 (-)
LP/J MGP_LPJ_G0028280
 protein coding gene Chr4:62656963-62695531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028176
 protein coding gene Chr4:69883667-69921874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028824
 protein coding gene Chr4:61877902-61915472 (-)
PWK/PhJ MGP_PWKPhJ_G0027231
 protein coding gene Chr4:58517685-58554132 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027056
 protein coding gene Chr4:59337923-59374057 (-)
WSB/EiJ MGP_WSBEiJ_G0027582
 protein coding gene Chr4:61907937-61946970 (-)



Homology
more
  • Human Ortholog
    AKNA, AT-hook transcription factor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AKNA, AT-hook transcription factor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 80709
    neXtProt AC: NX_Q7Z591
    UniProt: Q7Z591

  • Chr Location
    9q32; chr9:114334149-114398498 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic or a knock-out allele exhibit partial postnatal lethality, pathogen-induced acute neutrophil responses leading to systemic inflammation and alveolar destruction, and increased susceptibility to fungal infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    245
  • Tissues
    154
  • cDNA Data
    43
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039158 Ensembl Gene Model | MGI Sequence Detail 36230 C57BL/6J ±  kb
    transcript ENSMUST00000035724 Ensembl | MGI Sequence Detail 5387 Not Applicable  
    polypeptide ENSMUSP00000041614 Ensembl | MGI Sequence Detail 1404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 43
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:273640 Camargo Ortega G, et al., The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature. 2019 Mar;567(7746):113-117
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/18/2020
    MGI 6.14     		The Jackson Laboratory