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Gene Detail
latrophilin 2
Synonyms Lec1, Lphh1, mKIAA0786
Feature Type protein coding gene
Genetic Map
Chromosome 3
74.10 cM
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr3:148815586-148954635 bp, - strand
From NCBI annotation of GRCm38

  139050 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:22712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-latrotoxin receptor, calcium-independent type
Gene Tree: Lphn2

Human Homolog LPHN2, latrophilin 2
NCBI Gene ID 23266
neXtProt AC  NX_O95490
Human Synonyms  CIRL2, CL2, LEC1, LPHH1
Human Chr (Location)  1p31.1; chr1:81579300-81992423 (+)  GRCh38
alleles, and
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Genomic Mutations involving Lphn2 (1)
Incidental mutations (data from Mutagenetix , APF )
Homozygous null mice die prenatally at fetal stages. Heterozygous mice exhibit decreased locomotor activity in an open field test.
Lphn2 interacts with 317 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (15 annotations)
Process cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
External Resources: FuncBase
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(9) cDNA(9)
Microarray probesets(11)
Other database
Ensembl Gene ModelENSMUSG00000028184 (Evidence)
Entrez Gene99633 (Evidence)
DFCITC1582964, TC1601410, TC1612222, TC1615910, TC1626015, TC1651975
DoTSDT.101260559, DT.103567597, DT.531198, DT.91321086, DT.91366427, DT.91576680, DT.91581591, DT.91583404, DT.97354757
NIA Mouse Gene IndexU024748, U080292
International Mouse Knockout Project StatusLphn2
Representative SequencesLengthStrain/SpeciesFlank
genomic 99633 NCBI Gene Model | MGI Sequence Detail 139050 C57BL/6J ±  kb
transcript NM_001081298 RefSeq | MGI Sequence Detail 6052 Not Specified 
polypeptide Q8JZZ7 UniProt | EBI | MGI Sequence Detail 891 Not Applicable 

For the selected sequences
All sequences(129) RefSeq(83) UniProt(4)
Polymorphisms SNPs within 2kb(1084 from dbSNP Build 137)
InterPro IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003924 GPCR, family 2, latrophilin
InterPro IPR003334 GPCR, family 2, latrophilin, C-terminal
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS domain
InterPro IPR003112 Olfactomedin-like
Protein Ontology PR:000001234 latrophilin-2
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:90622 Bjarnadottir TK, et al., The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004 Jul;84(1):23-33
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory