Gene Expression Literature Summary

• Symbol: Adgrl2
• Name: adhesion G protein-coupled receptor L2
• ID: MGI:2139714

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E19	E20	P
Immunohistochemistry (section)		1				1			1					4
In situ RNA (section)				1	2		2	2	1	2				4
Immunohistochemistry (whole mount)						1			1		1			3
In situ RNA (whole mount)	1													1
In situ reporter (knock in)					1									1
Western blot														2
RT-PCR			1	1		1						1	1	3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Adgrl2  adhesion G protein-coupled receptor L2   (Synonyms: Lec1, Lphh1, Lphn2, mKIAA0786)
Results	Reference
9	J:385967 Chon U, Pederick DT, Song JH, Zhang Y, Rana I, Luo L, Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly. Curr Biol. 2026 May 8;
3	J:380210 Del Toro D, Carrasquero-Ordaz MA, Chu A, Ruff T, Shahin M, Jackson VA, Chavent M, Berbeira-Santana M, Seyit-Bremer G, Brignani S, Kaufmann R, Lowe E, Klein R, Seiradake E, Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Cell. 2020 Jan 23;180(2):323-339.e19
4	J:385796 Gingrich EC, Pederick DT, Zhang Y, Luo L, Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly. Curr Biol. 2026 May 8;
1	J:376291 Kang M, Lee CS, Son H, Lee J, Lee J, Seo HJ, Kim MK, Choi M, Cho HJ, Kim HS, Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell Junction, Leading to D-CMP. Circ Res. 2024 Nov 8;135(11):1098-1115
2*	J:297371 Lee CS, Cho HJ, Lee JW, Lee J, Kwon YW, Son T, Park H, Kim J, Kim HS, Identification of Latrophilin-2 as a Novel Cell-Surface Marker for the Cardiomyogenic Lineage and Its Functional Significance in Heart Development. Circulation. 2019 Jun 18;139(25):2910-2912
2*	J:348278 Liakath-Ali K, Refaee R, Sudhof TC, Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development. PLoS Biol. 2024 May;22(5):e3002599
1*	J:306191 Monteiro FA, Miranda RM, Samina MC, Dias AF, Raposo AASF, Oliveira P, Reguenga C, Castro DS, Lima D, Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord. Front Cell Dev Biol. 2021;9:642697
1*	J:281311 Nakano Y, Wiechert S, Banfi B, Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8
4*	J:385699 Sangster KT, Zhang X, Del Toro D, Sarantopoulos C, Moses AM, Mahasenan S, Pederick DT, Perreault S, Fallet-Bianco C, Roome RB, Seiradake E, Luo L, Kania A, Teneurin-3 and latrophilin-2 are required for somatotopic map development and somatosensory topognosis. Curr Biol. 2026 May 8;
1*	J:347608 Vezain M, Lecuyer M, Rubio M, Dupe V, Ratie L, David V, Pasquier L, Odent S, Coutant S, Tournier I, Trestard L, Adle-Biassette H, Vivien D, Frebourg T, Gonzalez BJ, Laquerriere A, Saugier-Veber P, A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis. Acta Neuropathol Commun. 2018 Oct 19;6(1):109
8	J:375698 Yang Z, Zhou SH, Zhang QY, Song ZC, Liu WW, Sun Y, Wang MW, Fu XL, Zhu KK, Guan Y, Qi JY, Wang XH, Sun YN, Lu Y, Ping YQ, Xi YT, Teng ZX, Xu L, Xiao P, Xu ZG, Xiong W, Qin W, Yang W, Yi F, Chai RJ, Yu X, Sun JP, A force-sensitive adhesion GPCR is required for equilibrioception. Cell Res. 2025 Apr;35(4):243-264
5	J:376302 Zhou SH, Wang MW, Song ZC, Yang Z, Zhu KK, Wen X, Zhang QY, Guan Y, Gao JR, Wang XH, Wang YQ, Liu WW, Xu L, Xiong W, Chai RJ, Wang C, Xu ZG, Yu X, Sun JP, The force-sensing GPCR LPHN2 is indispensable for normal auditory function. Cell Rep. 2025 Nov 25;44(11):116519